Mechanism and Prospect of Gastrodin in Osteoporosis, Bone Regeneration, and Osseointegration
Gastrodin, a traditional Chinese medicine ingredient, is widely used to treat vascular and neurological diseases. However, recently, an increasing number of studies have shown that gastrodin has anti-osteoporosis effects, and its mechanisms of action include its antioxidant effect, anti-inflammatory...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/11/1432 |
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| author | Yi Li Fenglan Li |
| author_facet | Yi Li Fenglan Li |
| author_sort | Yi Li |
| collection | DOAJ |
| description | Gastrodin, a traditional Chinese medicine ingredient, is widely used to treat vascular and neurological diseases. However, recently, an increasing number of studies have shown that gastrodin has anti-osteoporosis effects, and its mechanisms of action include its antioxidant effect, anti-inflammatory effect, and anti-apoptotic effect. In addition, gastrodin has many unique advantages in promoting bone healing in tissue engineering, such as inducing high hydrophilicity in the material surface, its anti-inflammatory effect, and pro-vascular regeneration. Therefore, this paper summarized the effects and mechanisms of gastrodin on osteoporosis and bone regeneration in the current research. Here we propose an assumption that the use of gastrodin in the surface loading of oral implants may greatly promote the osseointegration of implants and increase the success rate of implants. In addition, we speculated on the potential mechanisms of gastrodin against osteoporosis, by affecting actin filament polymerization, renin–angiotensin system (RAS) and ferroptosis, and proposed that the potential combination of gastrodin with Mg<sup>2+</sup>, angiotensin type 2 receptor blockers or artemisinin may greatly inhibit osteoporosis. The purpose of this review is to provide a reference for more in-depth research and application of gastrodin in the treatment of osteoporosis and implant osseointegration in the future. |
| first_indexed | 2024-03-09T18:04:50Z |
| format | Article |
| id | doaj.art-b1cb240a2e65472b8464bd553da520e0 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T18:04:50Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
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| series | Pharmaceuticals |
| spelling | doaj.art-b1cb240a2e65472b8464bd553da520e02023-11-24T09:35:38ZengMDPI AGPharmaceuticals1424-82472022-11-011511143210.3390/ph15111432Mechanism and Prospect of Gastrodin in Osteoporosis, Bone Regeneration, and OsseointegrationYi Li0Fenglan Li1Department of Prosthodontics, Shanxi Provincial People’s Hospital, Shanxi Medical University, Taiyuan 030000, ChinaDepartment of Prosthodontics, Shanxi Provincial People’s Hospital, Shanxi Medical University, Taiyuan 030000, ChinaGastrodin, a traditional Chinese medicine ingredient, is widely used to treat vascular and neurological diseases. However, recently, an increasing number of studies have shown that gastrodin has anti-osteoporosis effects, and its mechanisms of action include its antioxidant effect, anti-inflammatory effect, and anti-apoptotic effect. In addition, gastrodin has many unique advantages in promoting bone healing in tissue engineering, such as inducing high hydrophilicity in the material surface, its anti-inflammatory effect, and pro-vascular regeneration. Therefore, this paper summarized the effects and mechanisms of gastrodin on osteoporosis and bone regeneration in the current research. Here we propose an assumption that the use of gastrodin in the surface loading of oral implants may greatly promote the osseointegration of implants and increase the success rate of implants. In addition, we speculated on the potential mechanisms of gastrodin against osteoporosis, by affecting actin filament polymerization, renin–angiotensin system (RAS) and ferroptosis, and proposed that the potential combination of gastrodin with Mg<sup>2+</sup>, angiotensin type 2 receptor blockers or artemisinin may greatly inhibit osteoporosis. The purpose of this review is to provide a reference for more in-depth research and application of gastrodin in the treatment of osteoporosis and implant osseointegration in the future.https://www.mdpi.com/1424-8247/15/11/1432gastrodinosteoporosisbone regenerationosseointegrationactin filamentrenin-angiotensin system |
| spellingShingle | Yi Li Fenglan Li Mechanism and Prospect of Gastrodin in Osteoporosis, Bone Regeneration, and Osseointegration Pharmaceuticals gastrodin osteoporosis bone regeneration osseointegration actin filament renin-angiotensin system |
| title | Mechanism and Prospect of Gastrodin in Osteoporosis, Bone Regeneration, and Osseointegration |
| title_full | Mechanism and Prospect of Gastrodin in Osteoporosis, Bone Regeneration, and Osseointegration |
| title_fullStr | Mechanism and Prospect of Gastrodin in Osteoporosis, Bone Regeneration, and Osseointegration |
| title_full_unstemmed | Mechanism and Prospect of Gastrodin in Osteoporosis, Bone Regeneration, and Osseointegration |
| title_short | Mechanism and Prospect of Gastrodin in Osteoporosis, Bone Regeneration, and Osseointegration |
| title_sort | mechanism and prospect of gastrodin in osteoporosis bone regeneration and osseointegration |
| topic | gastrodin osteoporosis bone regeneration osseointegration actin filament renin-angiotensin system |
| url | https://www.mdpi.com/1424-8247/15/11/1432 |
| work_keys_str_mv | AT yili mechanismandprospectofgastrodininosteoporosisboneregenerationandosseointegration AT fenglanli mechanismandprospectofgastrodininosteoporosisboneregenerationandosseointegration |