New Therapeutic Approaches for Allergy: A Review of Cell Therapy and Bio- or Nano-Material-Based Strategies
Allergy constitutes a major health issue due to its large prevalence. The established therapeutic approaches (allergen avoidance, antihistamines, and corticosteroids) do not address the underlying causes of the pathology, highlighting the need for other long-term treatment options. Antigen-specific...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/12/2149 |
| _version_ | 1797501528041324544 |
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| author | Juan L. Paris Paz de la Torre Ana I. Flores |
| author_facet | Juan L. Paris Paz de la Torre Ana I. Flores |
| author_sort | Juan L. Paris |
| collection | DOAJ |
| description | Allergy constitutes a major health issue due to its large prevalence. The established therapeutic approaches (allergen avoidance, antihistamines, and corticosteroids) do not address the underlying causes of the pathology, highlighting the need for other long-term treatment options. Antigen-specific immunotherapy enables the long-term control of allergic diseases by promoting immunological tolerance to the allergen. However, efficacious immunotherapies are not available for all possible allergens, and the risk of undesired reactions during therapy remains a concern, especially in patients with severe allergic reactions. In this context, two types of therapeutic strategies appear especially promising for the future in the context of allergy: cell therapy and bio- or nano-material-based therapy. In this review, the main strategies developed this far in these two types of strategies are discussed, with several examples illustrating the different approaches. |
| first_indexed | 2024-03-10T03:19:43Z |
| format | Article |
| id | doaj.art-b1cd2ade59d24af79b0731ef26c6cd8f |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T03:19:43Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-b1cd2ade59d24af79b0731ef26c6cd8f2023-11-23T10:06:34ZengMDPI AGPharmaceutics1999-49232021-12-011312214910.3390/pharmaceutics13122149New Therapeutic Approaches for Allergy: A Review of Cell Therapy and Bio- or Nano-Material-Based StrategiesJuan L. Paris0Paz de la Torre1Ana I. Flores2Allergy Research Group, Instituto de Investigación Biomédica de Málaga-IBIMA, 29010 Málaga, SpainGrupo de Medicina Regenerativa, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, SpainGrupo de Medicina Regenerativa, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, SpainAllergy constitutes a major health issue due to its large prevalence. The established therapeutic approaches (allergen avoidance, antihistamines, and corticosteroids) do not address the underlying causes of the pathology, highlighting the need for other long-term treatment options. Antigen-specific immunotherapy enables the long-term control of allergic diseases by promoting immunological tolerance to the allergen. However, efficacious immunotherapies are not available for all possible allergens, and the risk of undesired reactions during therapy remains a concern, especially in patients with severe allergic reactions. In this context, two types of therapeutic strategies appear especially promising for the future in the context of allergy: cell therapy and bio- or nano-material-based therapy. In this review, the main strategies developed this far in these two types of strategies are discussed, with several examples illustrating the different approaches.https://www.mdpi.com/1999-4923/13/12/2149allergycell therapybiomaterialsnano-materialsimmunotherapy |
| spellingShingle | Juan L. Paris Paz de la Torre Ana I. Flores New Therapeutic Approaches for Allergy: A Review of Cell Therapy and Bio- or Nano-Material-Based Strategies Pharmaceutics allergy cell therapy biomaterials nano-materials immunotherapy |
| title | New Therapeutic Approaches for Allergy: A Review of Cell Therapy and Bio- or Nano-Material-Based Strategies |
| title_full | New Therapeutic Approaches for Allergy: A Review of Cell Therapy and Bio- or Nano-Material-Based Strategies |
| title_fullStr | New Therapeutic Approaches for Allergy: A Review of Cell Therapy and Bio- or Nano-Material-Based Strategies |
| title_full_unstemmed | New Therapeutic Approaches for Allergy: A Review of Cell Therapy and Bio- or Nano-Material-Based Strategies |
| title_short | New Therapeutic Approaches for Allergy: A Review of Cell Therapy and Bio- or Nano-Material-Based Strategies |
| title_sort | new therapeutic approaches for allergy a review of cell therapy and bio or nano material based strategies |
| topic | allergy cell therapy biomaterials nano-materials immunotherapy |
| url | https://www.mdpi.com/1999-4923/13/12/2149 |
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