Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state
BACKGROUND The first dengue cases in Brazil with laboratory confirmation occurred in the northern region of the country, with the isolation of two serotypes, dengue virus 1 (DENV-1) and DENV-4. In Ceará, the introduction of DENV-4 was reported during a DENV-1 epidemic in 2011, with only two isolatio...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
2018-10-01
|
| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001100300&lng=en&tlng=en |
| _version_ | 1797704748701319168 |
|---|---|
| author | Izabel Letícia Cavalcante Ramalho Fernanda Montenegro de Carvalho Araújo Luciano Pamplona de Góes Cavalcanti Deborah Nunes Melo Braga Anne Carolinne Bezerra Perdigão Flavia Barreto dos Santos Fernanda de Bruycker Nogueira Kiliana Nogueira Farias da Escóssia Maria Izabel Florindo Guedes |
| author_facet | Izabel Letícia Cavalcante Ramalho Fernanda Montenegro de Carvalho Araújo Luciano Pamplona de Góes Cavalcanti Deborah Nunes Melo Braga Anne Carolinne Bezerra Perdigão Flavia Barreto dos Santos Fernanda de Bruycker Nogueira Kiliana Nogueira Farias da Escóssia Maria Izabel Florindo Guedes |
| author_sort | Izabel Letícia Cavalcante Ramalho |
| collection | DOAJ |
| description | BACKGROUND The first dengue cases in Brazil with laboratory confirmation occurred in the northern region of the country, with the isolation of two serotypes, dengue virus 1 (DENV-1) and DENV-4. In Ceará, the introduction of DENV-4 was reported during a DENV-1 epidemic in 2011, with only two isolations. OBJECTIVES The aim of this study was to characterise the first DENV-4 epidemic in the state of Ceará, Brazil. METHODS The study population was composed of patients with suspected dengue that were reported to health care units from January to December 2012. The laboratory confirmation of infection was made by viral isolation, reverse transcription polymerase chain reaction (RT-PCR), AgNS1, immunohistochemistry and IgM enzyme-linked immunosorbent assay (ELISA). MAIN CONCLUSIONS In the study year, 72,211 suspected dengue cases were reported and 51,865 of these cases (71.8%) were confirmed to be positive. Co-circulation of three serotypes, DENV-1, DENV-3 and DENV-4, was detected with a predominance of DENV-4 (95.3%). Most cases were not severe, but there were 44 fatal outcomes. DENV-4 Genotype II was identified for the first time in Ceará. |
| first_indexed | 2024-03-12T05:25:00Z |
| format | Article |
| id | doaj.art-b1cda71bbc4a42428c1f276b6370ef78 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T05:25:00Z |
| publishDate | 2018-10-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-b1cda71bbc4a42428c1f276b6370ef782023-09-03T07:24:46ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602018-10-011131110.1590/0074-02760180320S0074-02762018001100300Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the stateIzabel Letícia Cavalcante RamalhoFernanda Montenegro de Carvalho AraújoLuciano Pamplona de Góes CavalcantiDeborah Nunes Melo BragaAnne Carolinne Bezerra PerdigãoFlavia Barreto dos SantosFernanda de Bruycker NogueiraKiliana Nogueira Farias da EscóssiaMaria Izabel Florindo GuedesBACKGROUND The first dengue cases in Brazil with laboratory confirmation occurred in the northern region of the country, with the isolation of two serotypes, dengue virus 1 (DENV-1) and DENV-4. In Ceará, the introduction of DENV-4 was reported during a DENV-1 epidemic in 2011, with only two isolations. OBJECTIVES The aim of this study was to characterise the first DENV-4 epidemic in the state of Ceará, Brazil. METHODS The study population was composed of patients with suspected dengue that were reported to health care units from January to December 2012. The laboratory confirmation of infection was made by viral isolation, reverse transcription polymerase chain reaction (RT-PCR), AgNS1, immunohistochemistry and IgM enzyme-linked immunosorbent assay (ELISA). MAIN CONCLUSIONS In the study year, 72,211 suspected dengue cases were reported and 51,865 of these cases (71.8%) were confirmed to be positive. Co-circulation of three serotypes, DENV-1, DENV-3 and DENV-4, was detected with a predominance of DENV-4 (95.3%). Most cases were not severe, but there were 44 fatal outcomes. DENV-4 Genotype II was identified for the first time in Ceará.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001100300&lng=en&tlng=endengue 4epidemiologydeathsgenotypingCeará/Brazil |
| spellingShingle | Izabel Letícia Cavalcante Ramalho Fernanda Montenegro de Carvalho Araújo Luciano Pamplona de Góes Cavalcanti Deborah Nunes Melo Braga Anne Carolinne Bezerra Perdigão Flavia Barreto dos Santos Fernanda de Bruycker Nogueira Kiliana Nogueira Farias da Escóssia Maria Izabel Florindo Guedes Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state Memorias do Instituto Oswaldo Cruz dengue 4 epidemiology deaths genotyping Ceará/Brazil |
| title | Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state |
| title_full | Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state |
| title_fullStr | Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state |
| title_full_unstemmed | Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state |
| title_short | Dengue 4 in Ceará, Brazil: characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state |
| title_sort | dengue 4 in ceara brazil characterisation of epidemiological and laboratorial aspects and causes of death during the first epidemic in the state |
| topic | dengue 4 epidemiology deaths genotyping Ceará/Brazil |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001100300&lng=en&tlng=en |
| work_keys_str_mv | AT izabelleticiacavalcanteramalho dengue4incearabrazilcharacterisationofepidemiologicalandlaboratorialaspectsandcausesofdeathduringthefirstepidemicinthestate AT fernandamontenegrodecarvalhoaraujo dengue4incearabrazilcharacterisationofepidemiologicalandlaboratorialaspectsandcausesofdeathduringthefirstepidemicinthestate AT lucianopamplonadegoescavalcanti dengue4incearabrazilcharacterisationofepidemiologicalandlaboratorialaspectsandcausesofdeathduringthefirstepidemicinthestate AT deborahnunesmelobraga dengue4incearabrazilcharacterisationofepidemiologicalandlaboratorialaspectsandcausesofdeathduringthefirstepidemicinthestate AT annecarolinnebezerraperdigao dengue4incearabrazilcharacterisationofepidemiologicalandlaboratorialaspectsandcausesofdeathduringthefirstepidemicinthestate AT flaviabarretodossantos dengue4incearabrazilcharacterisationofepidemiologicalandlaboratorialaspectsandcausesofdeathduringthefirstepidemicinthestate AT fernandadebruyckernogueira dengue4incearabrazilcharacterisationofepidemiologicalandlaboratorialaspectsandcausesofdeathduringthefirstepidemicinthestate AT kiliananogueirafariasdaescossia dengue4incearabrazilcharacterisationofepidemiologicalandlaboratorialaspectsandcausesofdeathduringthefirstepidemicinthestate AT mariaizabelflorindoguedes dengue4incearabrazilcharacterisationofepidemiologicalandlaboratorialaspectsandcausesofdeathduringthefirstepidemicinthestate |