Adherence to antihypertensive drug treatment in patients with apparently treatment-resistant hypertension in the INSPiRED pilot study
Purpose: Drug adherence may be a major problem in the therapy of hypertension and in the diagnosis of therapy resistance. Adherence can be assessed by indirect methods or by direct methods like drug detection in urine with liquid chromatography-mass spectrometric methods. Materials and methods: The...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-05-01
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| Series: | Blood Pressure |
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| Online Access: | http://dx.doi.org/10.1080/08037051.2019.1599814 |
| _version_ | 1797685098650271744 |
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| author | Cora Wunder Alexandre Persu Jean-Philippe Lengelé Coralie MG Georges Jean Renkin Agnès Pasquet Marc Carlier Zhen-Yu Zhang Jan A. Staessen The European Network Coordinating Research on Renal Denervation (ENCOReD), Stefan W. Toennes |
| author_facet | Cora Wunder Alexandre Persu Jean-Philippe Lengelé Coralie MG Georges Jean Renkin Agnès Pasquet Marc Carlier Zhen-Yu Zhang Jan A. Staessen The European Network Coordinating Research on Renal Denervation (ENCOReD), Stefan W. Toennes |
| author_sort | Cora Wunder |
| collection | DOAJ |
| description | Purpose: Drug adherence may be a major problem in the therapy of hypertension and in the diagnosis of therapy resistance. Adherence can be assessed by indirect methods or by direct methods like drug detection in urine with liquid chromatography-mass spectrometric methods. Materials and methods: The current analysis included patients with apparently treatment- resistant hypertension (TRH) referred for renal denervation (RDN) and included in the the INSPiRED pilot trial (NCT 01505010). Adherence was repeatedly assessed by toxicological urine analysis over a time range of up to 17 months in a total of 18 patients. Results: In the first urine samples of 18 patients the adherence rate (percentage of number of detected vs. prescribed medical drugs) ranged from 0 to 100% with a median of 73.2%. In further urine samples collected during the following up to 17 months every individual patient exhibited considerable changes in the adherence rate, neither a constancy nor a tendency could be deduced. Conclusions: Urine analysis results exhibit variation over time and an assessment at a certain time point cannot be regarded as representative or predictor for future behavior. Therefore, it appears necessary to perform drug adherence testing repeatedly over time. Trial registration: ClinicalTrials.gov identifier: NCT01505010. |
| first_indexed | 2024-03-12T00:39:26Z |
| format | Article |
| id | doaj.art-b1ce647f9e9b4b469251b3a33ab4939e |
| institution | Directory Open Access Journal |
| issn | 0803-7051 1651-1999 |
| language | English |
| last_indexed | 2024-03-12T00:39:26Z |
| publishDate | 2019-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Blood Pressure |
| spelling | doaj.art-b1ce647f9e9b4b469251b3a33ab4939e2023-09-15T08:45:22ZengTaylor & Francis GroupBlood Pressure0803-70511651-19992019-05-0128316817210.1080/08037051.2019.15998141599814Adherence to antihypertensive drug treatment in patients with apparently treatment-resistant hypertension in the INSPiRED pilot studyCora Wunder0Alexandre Persu1Jean-Philippe Lengelé2Coralie MG Georges3Jean Renkin4Agnès Pasquet5Marc Carlier6Zhen-Yu Zhang7Jan A. Staessen8The European Network Coordinating Research on Renal Denervation (ENCOReD), Stefan W. Toennes9Institute of Legal Medicine, Goethe-University FrankfurtCliniques Universitaires Saint-Luc, Université Catholique de LouvainCliniques Universitaires Saint-Luc, Université Catholique de LouvainCliniques Universitaires Saint-Luc, Université Catholique de LouvainCliniques Universitaires Saint-Luc, Université Catholique de LouvainCliniques Universitaires Saint-Luc, Université Catholique de LouvainGrand Hôpital de CharleroiUniversity of LeuvenUniversity of LeuvenInstitute of Legal Medicine, Goethe-University FrankfurtPurpose: Drug adherence may be a major problem in the therapy of hypertension and in the diagnosis of therapy resistance. Adherence can be assessed by indirect methods or by direct methods like drug detection in urine with liquid chromatography-mass spectrometric methods. Materials and methods: The current analysis included patients with apparently treatment- resistant hypertension (TRH) referred for renal denervation (RDN) and included in the the INSPiRED pilot trial (NCT 01505010). Adherence was repeatedly assessed by toxicological urine analysis over a time range of up to 17 months in a total of 18 patients. Results: In the first urine samples of 18 patients the adherence rate (percentage of number of detected vs. prescribed medical drugs) ranged from 0 to 100% with a median of 73.2%. In further urine samples collected during the following up to 17 months every individual patient exhibited considerable changes in the adherence rate, neither a constancy nor a tendency could be deduced. Conclusions: Urine analysis results exhibit variation over time and an assessment at a certain time point cannot be regarded as representative or predictor for future behavior. Therefore, it appears necessary to perform drug adherence testing repeatedly over time. Trial registration: ClinicalTrials.gov identifier: NCT01505010.http://dx.doi.org/10.1080/08037051.2019.1599814complianceresistant hypertensiontoxicological analysisantihypertensive drugsrenal denervation |
| spellingShingle | Cora Wunder Alexandre Persu Jean-Philippe Lengelé Coralie MG Georges Jean Renkin Agnès Pasquet Marc Carlier Zhen-Yu Zhang Jan A. Staessen The European Network Coordinating Research on Renal Denervation (ENCOReD), Stefan W. Toennes Adherence to antihypertensive drug treatment in patients with apparently treatment-resistant hypertension in the INSPiRED pilot study Blood Pressure compliance resistant hypertension toxicological analysis antihypertensive drugs renal denervation |
| title | Adherence to antihypertensive drug treatment in patients with apparently treatment-resistant hypertension in the INSPiRED pilot study |
| title_full | Adherence to antihypertensive drug treatment in patients with apparently treatment-resistant hypertension in the INSPiRED pilot study |
| title_fullStr | Adherence to antihypertensive drug treatment in patients with apparently treatment-resistant hypertension in the INSPiRED pilot study |
| title_full_unstemmed | Adherence to antihypertensive drug treatment in patients with apparently treatment-resistant hypertension in the INSPiRED pilot study |
| title_short | Adherence to antihypertensive drug treatment in patients with apparently treatment-resistant hypertension in the INSPiRED pilot study |
| title_sort | adherence to antihypertensive drug treatment in patients with apparently treatment resistant hypertension in the inspired pilot study |
| topic | compliance resistant hypertension toxicological analysis antihypertensive drugs renal denervation |
| url | http://dx.doi.org/10.1080/08037051.2019.1599814 |
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