Decellularized diseased tissues: current state‐of‐the‐art and future directions
Abstract Decellularized matrices derived from diseased tissues/organs have evolved in the most recent years, providing novel research perspectives for understanding disease occurrence and progression and providing accurate pseudo models for developing new disease treatments. Although decellularized...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-12-01
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| Series: | MedComm |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mco2.399 |
| _version_ | 1797373563002421248 |
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| author | Xiang Li Jianyang Shan Xin Chen Haomin Cui Gen Wen Yaling Yu |
| author_facet | Xiang Li Jianyang Shan Xin Chen Haomin Cui Gen Wen Yaling Yu |
| author_sort | Xiang Li |
| collection | DOAJ |
| description | Abstract Decellularized matrices derived from diseased tissues/organs have evolved in the most recent years, providing novel research perspectives for understanding disease occurrence and progression and providing accurate pseudo models for developing new disease treatments. Although decellularized matrix maintaining the native composition, ultrastructure, and biomechanical characteristics of extracellular matrix (ECM), alongside intact and perfusable vascular compartments, facilitates the construction of bioengineered organ explants in vitro and promotes angiogenesis and tissue/organ regeneration in vivo, the availability of healthy tissues and organs for the preparation of decellularized ECM materials is limited. In this paper, we review the research advancements in decellularized diseased matrices. Considering that current research focuses on the matrices derived from cancers and fibrotic organs (mainly fibrotic kidney, lungs, and liver), the pathological characterizations and the applications of these diseased matrices are mainly discussed. Additionally, a contrastive analysis between the decellularized diseased matrices and decellularized healthy matrices, along with the development in vitro 3D models, is discussed in this paper. And last, we have provided the challenges and future directions in this review. Deep and comprehensive research on decellularized diseased tissues and organs will promote in‐depth exploration of source materials in tissue engineering field, thus providing new ideas for clinical transformation. |
| first_indexed | 2024-03-08T18:52:18Z |
| format | Article |
| id | doaj.art-b1ceb2fe2fa8484e82ded2068da864dd |
| institution | Directory Open Access Journal |
| issn | 2688-2663 |
| language | English |
| last_indexed | 2024-03-08T18:52:18Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj.art-b1ceb2fe2fa8484e82ded2068da864dd2023-12-28T16:52:34ZengWileyMedComm2688-26632023-12-0146n/an/a10.1002/mco2.399Decellularized diseased tissues: current state‐of‐the‐art and future directionsXiang Li0Jianyang Shan1Xin Chen2Haomin Cui3Gen Wen4Yaling Yu5Department of Orthopedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Orthopedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Orthopedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Orthopedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Orthopedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Orthopedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai ChinaAbstract Decellularized matrices derived from diseased tissues/organs have evolved in the most recent years, providing novel research perspectives for understanding disease occurrence and progression and providing accurate pseudo models for developing new disease treatments. Although decellularized matrix maintaining the native composition, ultrastructure, and biomechanical characteristics of extracellular matrix (ECM), alongside intact and perfusable vascular compartments, facilitates the construction of bioengineered organ explants in vitro and promotes angiogenesis and tissue/organ regeneration in vivo, the availability of healthy tissues and organs for the preparation of decellularized ECM materials is limited. In this paper, we review the research advancements in decellularized diseased matrices. Considering that current research focuses on the matrices derived from cancers and fibrotic organs (mainly fibrotic kidney, lungs, and liver), the pathological characterizations and the applications of these diseased matrices are mainly discussed. Additionally, a contrastive analysis between the decellularized diseased matrices and decellularized healthy matrices, along with the development in vitro 3D models, is discussed in this paper. And last, we have provided the challenges and future directions in this review. Deep and comprehensive research on decellularized diseased tissues and organs will promote in‐depth exploration of source materials in tissue engineering field, thus providing new ideas for clinical transformation.https://doi.org/10.1002/mco2.399cancerdecellularizeddisease modelingECMfibrosis |
| spellingShingle | Xiang Li Jianyang Shan Xin Chen Haomin Cui Gen Wen Yaling Yu Decellularized diseased tissues: current state‐of‐the‐art and future directions MedComm cancer decellularized disease modeling ECM fibrosis |
| title | Decellularized diseased tissues: current state‐of‐the‐art and future directions |
| title_full | Decellularized diseased tissues: current state‐of‐the‐art and future directions |
| title_fullStr | Decellularized diseased tissues: current state‐of‐the‐art and future directions |
| title_full_unstemmed | Decellularized diseased tissues: current state‐of‐the‐art and future directions |
| title_short | Decellularized diseased tissues: current state‐of‐the‐art and future directions |
| title_sort | decellularized diseased tissues current state of the art and future directions |
| topic | cancer decellularized disease modeling ECM fibrosis |
| url | https://doi.org/10.1002/mco2.399 |
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