Selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection.
An imbalance between pro-survival and pro-death pathways in brain cells can lead to neuronal cell death and neurodegeneration. While such imbalance is known to be associated with alterations in glutamatergic and Ca(2+) signaling, the underlying mechanisms remain undefined. We identified the protein...
Main Authors: | Mélissa Farinelli, Fabrice D Heitz, Benjamin F Grewe, Shiva K Tyagarajan, Fritjof Helmchen, Isabelle M Mansuy |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3316588?pdf=render |
Similar Items
-
Neuroprotective Mechanisms of Lycium barbarum Polysaccharides Against Ischemic Insults by Regulating NR2B and NR2A Containing NMDA Receptor Signaling Pathways
by: Zhongshan Shi, et al.
Published: (2017-09-01) -
Neuron to astrocyte communication via cannabinoid receptors is necessary for sustained epileptiform activity in rat hippocampus.
by: Guyllaume Coiret, et al.
Published: (2012-01-01) -
LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses
by: Alessandra Sclip, et al.
Published: (2020-01-01) -
Targeting NMDA Receptors in Emotional Disorders: Their Role in Neuroprotection
by: Siqi Wang, et al.
Published: (2022-09-01) -
Targeting NMDA receptors in stroke: new hope in neuroprotection
by: Qiu Jing Wu, et al.
Published: (2018-03-01)