Genetically supported causality between gut microbiota and frailty: a two-sample Mendelian randomization study
BackgroundA mounting body of evidence suggests a strong connection between gut microbiota and the risk of frailty. However, the question of causality remains unanswered. In this study, we employed a Mendelian randomization (MR) approach to assess potential causal relationships between gut microbiota...
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1324209/full |
| _version_ | 1797202982484312064 |
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| author | Zi Wang Zi Wang Han Shuai Han Shuai Yinggang Xiao Yinggang Xiao Yang Zhang Yali Ge Ju Gao Xin Liu |
| author_facet | Zi Wang Zi Wang Han Shuai Han Shuai Yinggang Xiao Yinggang Xiao Yang Zhang Yali Ge Ju Gao Xin Liu |
| author_sort | Zi Wang |
| collection | DOAJ |
| description | BackgroundA mounting body of evidence suggests a strong connection between gut microbiota and the risk of frailty. However, the question of causality remains unanswered. In this study, we employed a Mendelian randomization (MR) approach to assess potential causal relationships between gut microbiota and the risk of frailty.Materials and methodsSummary statistics for the gut microbiome were obtained from a genome wide association study (GWAS) meta-analysis of the MiBioGen consortium (N = 18,340). Summary statistics for frailty were obtained from a GWAS meta-analysis, including the UK Biobank and TwinGene (N = 175,226). Our primary analysis utilized the inverse variance weighted (IVW) method. To enhance the robustness of our results, we also applied weighted median methods, MR Egger regression, and MR pleiotropy residual sum and outlier test. Finally, we conducted reverse MR analysis to investigate the potential for reverse causality.ResultsIVW method identified 7 bacterial taxa nominally associated with the risk of FI. Class Bacteroidia (p = 0.033) and genus Eubacterium ruminantium group (p = 0.028) were protective against FI. In addition, class Betaproteobacteria (p = 0.042), genus Allisonella (p = 0.012), genus Bifidobacterium (p = 0.013), genus Clostridium innocuum group (p = 0.036) and genus Eubacterium coprostanoligenes group (p = 0.003) were associated with a higher risk of FI. No pleiotropy or heterogeneity were found.ConclusionThe MR analysis indicates a causal relationship between specific gut microbiota and FI, offering new insights into the mechanisms underlying FI mediated by gut microbiota. |
| first_indexed | 2024-04-24T08:12:05Z |
| format | Article |
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| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-24T08:12:05Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Microbiology |
| spelling | doaj.art-b1d10aeb23b94c6d8434f7a2ed72f9742024-04-17T04:56:43ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-04-011510.3389/fmicb.2024.13242091324209Genetically supported causality between gut microbiota and frailty: a two-sample Mendelian randomization studyZi Wang0Zi Wang1Han Shuai2Han Shuai3Yinggang Xiao4Yinggang Xiao5Yang Zhang6Yali Ge7Ju Gao8Xin Liu9Yangzhou University Medical College, Yangzhou, ChinaDepartment of Anesthesiology, Institute of Anesthesia, Emergency and Critical Care, Yangzhou University Affiliated Northern Jiangsu People’s Hospital, Yangzhou, ChinaYangzhou University Medical College, Yangzhou, ChinaDepartment of Anesthesiology, Institute of Anesthesia, Emergency and Critical Care, Yangzhou University Affiliated Northern Jiangsu People’s Hospital, Yangzhou, ChinaYangzhou University Medical College, Yangzhou, ChinaDepartment of Anesthesiology, Institute of Anesthesia, Emergency and Critical Care, Yangzhou University Affiliated Northern Jiangsu People’s Hospital, Yangzhou, ChinaDepartment of Anesthesiology, Institute of Anesthesia, Emergency and Critical Care, Yangzhou University Affiliated Northern Jiangsu People’s Hospital, Yangzhou, ChinaDepartment of Anesthesiology, Institute of Anesthesia, Emergency and Critical Care, Yangzhou University Affiliated Northern Jiangsu People’s Hospital, Yangzhou, ChinaDepartment of Anesthesiology, Institute of Anesthesia, Emergency and Critical Care, Yangzhou University Affiliated Northern Jiangsu People’s Hospital, Yangzhou, ChinaDepartment of Anesthesiology, Institute of Anesthesia, Emergency and Critical Care, Yangzhou University Affiliated Northern Jiangsu People’s Hospital, Yangzhou, ChinaBackgroundA mounting body of evidence suggests a strong connection between gut microbiota and the risk of frailty. However, the question of causality remains unanswered. In this study, we employed a Mendelian randomization (MR) approach to assess potential causal relationships between gut microbiota and the risk of frailty.Materials and methodsSummary statistics for the gut microbiome were obtained from a genome wide association study (GWAS) meta-analysis of the MiBioGen consortium (N = 18,340). Summary statistics for frailty were obtained from a GWAS meta-analysis, including the UK Biobank and TwinGene (N = 175,226). Our primary analysis utilized the inverse variance weighted (IVW) method. To enhance the robustness of our results, we also applied weighted median methods, MR Egger regression, and MR pleiotropy residual sum and outlier test. Finally, we conducted reverse MR analysis to investigate the potential for reverse causality.ResultsIVW method identified 7 bacterial taxa nominally associated with the risk of FI. Class Bacteroidia (p = 0.033) and genus Eubacterium ruminantium group (p = 0.028) were protective against FI. In addition, class Betaproteobacteria (p = 0.042), genus Allisonella (p = 0.012), genus Bifidobacterium (p = 0.013), genus Clostridium innocuum group (p = 0.036) and genus Eubacterium coprostanoligenes group (p = 0.003) were associated with a higher risk of FI. No pleiotropy or heterogeneity were found.ConclusionThe MR analysis indicates a causal relationship between specific gut microbiota and FI, offering new insights into the mechanisms underlying FI mediated by gut microbiota.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1324209/fullgut microbiotafrailtyMendelian randomizationolder peoplecausal associationgenome-wide association study |
| spellingShingle | Zi Wang Zi Wang Han Shuai Han Shuai Yinggang Xiao Yinggang Xiao Yang Zhang Yali Ge Ju Gao Xin Liu Genetically supported causality between gut microbiota and frailty: a two-sample Mendelian randomization study Frontiers in Microbiology gut microbiota frailty Mendelian randomization older people causal association genome-wide association study |
| title | Genetically supported causality between gut microbiota and frailty: a two-sample Mendelian randomization study |
| title_full | Genetically supported causality between gut microbiota and frailty: a two-sample Mendelian randomization study |
| title_fullStr | Genetically supported causality between gut microbiota and frailty: a two-sample Mendelian randomization study |
| title_full_unstemmed | Genetically supported causality between gut microbiota and frailty: a two-sample Mendelian randomization study |
| title_short | Genetically supported causality between gut microbiota and frailty: a two-sample Mendelian randomization study |
| title_sort | genetically supported causality between gut microbiota and frailty a two sample mendelian randomization study |
| topic | gut microbiota frailty Mendelian randomization older people causal association genome-wide association study |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1324209/full |
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