Role of serum adiponectin levels and IL-10 as a marker for angiographic stenosis in coronary artery disease
Objectives: This study aimed to determine the association of interleukin (IL)-10 and adiponectin (Ad) levels with the angiographic severity of coronary artery disease (CAD). Methods: In this case–control study, the study population included 50 patients with angiographically proven CAD as the case gr...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2022-01-01
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| Series: | International Journal of the Cardiovascular Academy |
| Subjects: | |
| Online Access: | http://www.ijcva.com/article.asp?issn=2405-8181;year=2022;volume=8;issue=1;spage=8;epage=13;aulast=Tyagi |
| _version_ | 1827840869504385024 |
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| author | Nitin Tyagi Charanjeet Kaur |
| author_facet | Nitin Tyagi Charanjeet Kaur |
| author_sort | Nitin Tyagi |
| collection | DOAJ |
| description | Objectives: This study aimed to determine the association of interleukin (IL)-10 and adiponectin (Ad) levels with the angiographic severity of coronary artery disease (CAD). Methods: In this case–control study, the study population included 50 patients with angiographically proven CAD as the case group and 50 apparently healthy age and sex-matched adults as a control group. The severity of CAD was assessed by SYNTAX scores. Serum Ad levels and IL-10 were measured using ELISA-based kits. The levels of Ad and IL-10 were associated with angiographic severity of CAD. P < 0.05 was considered statistically significant. Results: Cases had significantly lower Ad level (1.89 ± 1.18 vs. 2.59 ± 1.48, P = 0.0003) and significantly higher IL-10 level (8.96 ± 6.84 vs. 3.5 ± 3.57, P < 0.0001) as compared to controls. There was a significant correlation between the levels of Ad and IL-10 (r = 0.315, P = 0.026). There was a significant negative correlation between the Ad and angiographic stenosis of CAD (r = ‒0.939, P < 0.001). Both Ad and IL-10 showed a significant association with the severity of CAD in terms of SYNTAX score. Conclusion: Patients with CAD had lower Ad levels and higher IL-10 levels. Ad levels showed a significant decrease with increasing coronary artery stenosis. Both the markers (Ad and IL-10) showed significant association with the severity of CAD, thereby signifying their role as a marker for CAD. |
| first_indexed | 2024-03-12T07:41:50Z |
| format | Article |
| id | doaj.art-b1d2d93e7bca4a229d1cbc44ac091ac9 |
| institution | Directory Open Access Journal |
| issn | 2405-8181 2405-819X |
| language | English |
| last_indexed | 2024-03-12T07:41:50Z |
| publishDate | 2022-01-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | International Journal of the Cardiovascular Academy |
| spelling | doaj.art-b1d2d93e7bca4a229d1cbc44ac091ac92023-09-02T21:17:10ZengGalenos Publishing HouseInternational Journal of the Cardiovascular Academy2405-81812405-819X2022-01-018181310.4103/ijca.ijca_47_21Role of serum adiponectin levels and IL-10 as a marker for angiographic stenosis in coronary artery diseaseNitin TyagiCharanjeet KaurObjectives: This study aimed to determine the association of interleukin (IL)-10 and adiponectin (Ad) levels with the angiographic severity of coronary artery disease (CAD). Methods: In this case–control study, the study population included 50 patients with angiographically proven CAD as the case group and 50 apparently healthy age and sex-matched adults as a control group. The severity of CAD was assessed by SYNTAX scores. Serum Ad levels and IL-10 were measured using ELISA-based kits. The levels of Ad and IL-10 were associated with angiographic severity of CAD. P < 0.05 was considered statistically significant. Results: Cases had significantly lower Ad level (1.89 ± 1.18 vs. 2.59 ± 1.48, P = 0.0003) and significantly higher IL-10 level (8.96 ± 6.84 vs. 3.5 ± 3.57, P < 0.0001) as compared to controls. There was a significant correlation between the levels of Ad and IL-10 (r = 0.315, P = 0.026). There was a significant negative correlation between the Ad and angiographic stenosis of CAD (r = ‒0.939, P < 0.001). Both Ad and IL-10 showed a significant association with the severity of CAD in terms of SYNTAX score. Conclusion: Patients with CAD had lower Ad levels and higher IL-10 levels. Ad levels showed a significant decrease with increasing coronary artery stenosis. Both the markers (Ad and IL-10) showed significant association with the severity of CAD, thereby signifying their role as a marker for CAD.http://www.ijcva.com/article.asp?issn=2405-8181;year=2022;volume=8;issue=1;spage=8;epage=13;aulast=Tyagiadiponectincoronary artery diseasestenosis |
| spellingShingle | Nitin Tyagi Charanjeet Kaur Role of serum adiponectin levels and IL-10 as a marker for angiographic stenosis in coronary artery disease International Journal of the Cardiovascular Academy adiponectin coronary artery disease stenosis |
| title | Role of serum adiponectin levels and IL-10 as a marker for angiographic stenosis in coronary artery disease |
| title_full | Role of serum adiponectin levels and IL-10 as a marker for angiographic stenosis in coronary artery disease |
| title_fullStr | Role of serum adiponectin levels and IL-10 as a marker for angiographic stenosis in coronary artery disease |
| title_full_unstemmed | Role of serum adiponectin levels and IL-10 as a marker for angiographic stenosis in coronary artery disease |
| title_short | Role of serum adiponectin levels and IL-10 as a marker for angiographic stenosis in coronary artery disease |
| title_sort | role of serum adiponectin levels and il 10 as a marker for angiographic stenosis in coronary artery disease |
| topic | adiponectin coronary artery disease stenosis |
| url | http://www.ijcva.com/article.asp?issn=2405-8181;year=2022;volume=8;issue=1;spage=8;epage=13;aulast=Tyagi |
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