The Peri-Implant Microbiome—A Possible Factor Determining the Success of Surgical Peri-Implantitis Treatment?
The objective was to assess the effect of peri-implantitis surgery on the peri-implant microbiome with a follow-up of one year. A total of 25 peri-implantitis patients in whom non-surgical treatment has failed to solve peri-implantitis underwent resective surgical treatment. Their peri-implant pocke...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Dentistry Journal |
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| Online Access: | https://www.mdpi.com/2304-6767/12/1/20 |
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| author | Jarno Hakkers Lei Liu Diederik F. M. Hentenaar Gerry M. Raghoebar Arjan Vissink Henny J. A. Meijer Lisa Walters Hermie J. M. Harmsen Yvonne C. M. de Waal |
| author_facet | Jarno Hakkers Lei Liu Diederik F. M. Hentenaar Gerry M. Raghoebar Arjan Vissink Henny J. A. Meijer Lisa Walters Hermie J. M. Harmsen Yvonne C. M. de Waal |
| author_sort | Jarno Hakkers |
| collection | DOAJ |
| description | The objective was to assess the effect of peri-implantitis surgery on the peri-implant microbiome with a follow-up of one year. A total of 25 peri-implantitis patients in whom non-surgical treatment has failed to solve peri-implantitis underwent resective surgical treatment. Their peri-implant pockets were sampled prior to surgical treatment (T0) and one year post treatment (T12). The natural dentition was sampled to analyse similarities and differences with the peri-implantitis samples. Treatment success was recorded. The change in microbial relative abundance levels was evaluated. The microbiota was analysed by sequencing the amplified V3-V4 region of the 16S rRNA genes. Sequence data were binned to amplicon sequence variants that were assigned to bacterial genera. Group differences were analysed using principal coordinate analysis, Wilcoxon signed rank tests, and <i>t</i>-tests. Beta diversity analyses reported a significant separation between peri-implantitis and natural dentition samples on T0 and T12, along with significant separations between successfully and non-successfully treated patients. <i>Eubacterium</i> was significantly lower on T12 compared to T0 for the peri-implantitis samples. <i>Treponema</i> and <i>Eubacterium</i> abundance levels were significantly lower in patients with treatment success on T0 and T12 versus no treatment success. Therefore, lower baseline levels of <i>Treponema</i> and <i>Eubacterium</i> seem to be associated with treatment success of peri-implantitis surgery. This study might aid clinicians in determining which peri-implantitis cases might be suitable for treatment and give a prognosis with regard to treatment success. |
| first_indexed | 2024-03-08T11:01:23Z |
| format | Article |
| id | doaj.art-b1d3eb23b666465185fd8695c3a66d6f |
| institution | Directory Open Access Journal |
| issn | 2304-6767 |
| language | English |
| last_indexed | 2024-03-08T11:01:23Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dentistry Journal |
| spelling | doaj.art-b1d3eb23b666465185fd8695c3a66d6f2024-01-26T16:00:05ZengMDPI AGDentistry Journal2304-67672024-01-011212010.3390/dj12010020The Peri-Implant Microbiome—A Possible Factor Determining the Success of Surgical Peri-Implantitis Treatment?Jarno Hakkers0Lei Liu1Diederik F. M. Hentenaar2Gerry M. Raghoebar3Arjan Vissink4Henny J. A. Meijer5Lisa Walters6Hermie J. M. Harmsen7Yvonne C. M. de Waal8Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The NetherlandsDepartment of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The NetherlandsDepartment of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The NetherlandsDepartment of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The NetherlandsDepartment of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The NetherlandsDepartment of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The NetherlandsDepartment of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The NetherlandsDepartment of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The NetherlandsCenter for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The NetherlandsThe objective was to assess the effect of peri-implantitis surgery on the peri-implant microbiome with a follow-up of one year. A total of 25 peri-implantitis patients in whom non-surgical treatment has failed to solve peri-implantitis underwent resective surgical treatment. Their peri-implant pockets were sampled prior to surgical treatment (T0) and one year post treatment (T12). The natural dentition was sampled to analyse similarities and differences with the peri-implantitis samples. Treatment success was recorded. The change in microbial relative abundance levels was evaluated. The microbiota was analysed by sequencing the amplified V3-V4 region of the 16S rRNA genes. Sequence data were binned to amplicon sequence variants that were assigned to bacterial genera. Group differences were analysed using principal coordinate analysis, Wilcoxon signed rank tests, and <i>t</i>-tests. Beta diversity analyses reported a significant separation between peri-implantitis and natural dentition samples on T0 and T12, along with significant separations between successfully and non-successfully treated patients. <i>Eubacterium</i> was significantly lower on T12 compared to T0 for the peri-implantitis samples. <i>Treponema</i> and <i>Eubacterium</i> abundance levels were significantly lower in patients with treatment success on T0 and T12 versus no treatment success. Therefore, lower baseline levels of <i>Treponema</i> and <i>Eubacterium</i> seem to be associated with treatment success of peri-implantitis surgery. This study might aid clinicians in determining which peri-implantitis cases might be suitable for treatment and give a prognosis with regard to treatment success.https://www.mdpi.com/2304-6767/12/1/20peri-implantitismicrobiologydental implantsurgical peri-implantitis treatment |
| spellingShingle | Jarno Hakkers Lei Liu Diederik F. M. Hentenaar Gerry M. Raghoebar Arjan Vissink Henny J. A. Meijer Lisa Walters Hermie J. M. Harmsen Yvonne C. M. de Waal The Peri-Implant Microbiome—A Possible Factor Determining the Success of Surgical Peri-Implantitis Treatment? Dentistry Journal peri-implantitis microbiology dental implant surgical peri-implantitis treatment |
| title | The Peri-Implant Microbiome—A Possible Factor Determining the Success of Surgical Peri-Implantitis Treatment? |
| title_full | The Peri-Implant Microbiome—A Possible Factor Determining the Success of Surgical Peri-Implantitis Treatment? |
| title_fullStr | The Peri-Implant Microbiome—A Possible Factor Determining the Success of Surgical Peri-Implantitis Treatment? |
| title_full_unstemmed | The Peri-Implant Microbiome—A Possible Factor Determining the Success of Surgical Peri-Implantitis Treatment? |
| title_short | The Peri-Implant Microbiome—A Possible Factor Determining the Success of Surgical Peri-Implantitis Treatment? |
| title_sort | peri implant microbiome a possible factor determining the success of surgical peri implantitis treatment |
| topic | peri-implantitis microbiology dental implant surgical peri-implantitis treatment |
| url | https://www.mdpi.com/2304-6767/12/1/20 |
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