RBP2 induces epithelial-mesenchymal transition in non-small cell lung cancer.
RBP2 has been found to actively participate in cancer progression. It inhibits the senescence of cancer cells, mediates cancer cell proliferation and promotes cancer metastasis. It is also essential to drug tolerance. However, the effects of RBP2 on epithelial-mesenchymal transition are still unknow...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3869927?pdf=render |
| _version_ | 1818520810750476288 |
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| author | Shikun Wang Yang Wang Haijian Wu Likuan Hu |
| author_facet | Shikun Wang Yang Wang Haijian Wu Likuan Hu |
| author_sort | Shikun Wang |
| collection | DOAJ |
| description | RBP2 has been found to actively participate in cancer progression. It inhibits the senescence of cancer cells, mediates cancer cell proliferation and promotes cancer metastasis. It is also essential to drug tolerance. However, the effects of RBP2 on epithelial-mesenchymal transition are still unknown. In this study, we analyzed the effects of RBP2 on epithelial-mesenchymal transition in non-small cell lung cancer. The results showed that RBP2 down-regulated the expression of E-cadherin by inhibiting the promoter activity of E-cadherin and up-regulated the expression of N-cadherin and snail via the activation of Akt signaling, and the overexpression of RBP2 induced epithelial-mesenchymal transition in non-small cell lung cancer cells. Our study further indicated that RBP2 may be a potential target for anti-lung cancer therapy. |
| first_indexed | 2024-12-11T01:42:39Z |
| format | Article |
| id | doaj.art-b1d68476146047a1a15415264e879988 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T01:42:39Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b1d68476146047a1a15415264e8799882022-12-22T01:25:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8473510.1371/journal.pone.0084735RBP2 induces epithelial-mesenchymal transition in non-small cell lung cancer.Shikun WangYang WangHaijian WuLikuan HuRBP2 has been found to actively participate in cancer progression. It inhibits the senescence of cancer cells, mediates cancer cell proliferation and promotes cancer metastasis. It is also essential to drug tolerance. However, the effects of RBP2 on epithelial-mesenchymal transition are still unknown. In this study, we analyzed the effects of RBP2 on epithelial-mesenchymal transition in non-small cell lung cancer. The results showed that RBP2 down-regulated the expression of E-cadherin by inhibiting the promoter activity of E-cadherin and up-regulated the expression of N-cadherin and snail via the activation of Akt signaling, and the overexpression of RBP2 induced epithelial-mesenchymal transition in non-small cell lung cancer cells. Our study further indicated that RBP2 may be a potential target for anti-lung cancer therapy.http://europepmc.org/articles/PMC3869927?pdf=render |
| spellingShingle | Shikun Wang Yang Wang Haijian Wu Likuan Hu RBP2 induces epithelial-mesenchymal transition in non-small cell lung cancer. PLoS ONE |
| title | RBP2 induces epithelial-mesenchymal transition in non-small cell lung cancer. |
| title_full | RBP2 induces epithelial-mesenchymal transition in non-small cell lung cancer. |
| title_fullStr | RBP2 induces epithelial-mesenchymal transition in non-small cell lung cancer. |
| title_full_unstemmed | RBP2 induces epithelial-mesenchymal transition in non-small cell lung cancer. |
| title_short | RBP2 induces epithelial-mesenchymal transition in non-small cell lung cancer. |
| title_sort | rbp2 induces epithelial mesenchymal transition in non small cell lung cancer |
| url | http://europepmc.org/articles/PMC3869927?pdf=render |
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