Investigation of a Cluster of Immunization Stress-Related Reactions after Coronavirus Disease 2019 (COVID-19) Vaccination, Thailand, 2021
On 28 April 2021, the investigation team of the Department of Disease Control, Ministry of Public Health, was notified of a cluster of people developing neurological symptoms following COVID-19 vaccination in a province in eastern Thailand. We conducted an investigation from 29 April to 20 May 2021...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/3/441 |
| _version_ | 1797441169684168704 |
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| author | Chayanit Mahasing Oiythip Yasopa Chalo Sansilapin Thanit Rattanathumsakul Panithee Thammawijaya Rapeepong Suphanchaimat Pawinee Doung-ngern |
| author_facet | Chayanit Mahasing Oiythip Yasopa Chalo Sansilapin Thanit Rattanathumsakul Panithee Thammawijaya Rapeepong Suphanchaimat Pawinee Doung-ngern |
| author_sort | Chayanit Mahasing |
| collection | DOAJ |
| description | On 28 April 2021, the investigation team of the Department of Disease Control, Ministry of Public Health, was notified of a cluster of people developing neurological symptoms following COVID-19 vaccination in a province in eastern Thailand. We conducted an investigation from 29 April to 20 May 2021 to confirm the outbreak, describe the epidemiological characteristics and identify possible risk factors. A matched case-control study was conducted. Matching factors were gender and vaccination site. A confirmed case was a person receiving COVID-19 vaccination in the province and developed at least one neurological symptom between 21 April and 20 May 2021. The rapid assessment of the vaccination cold chain system was carried out. We found a total of 36 cases out of 3920 vaccinees (attack rate = 0.92%), all cases were recovered and classified as an immunization stress-related reaction (ISRR) by the National AEFI Expert Committee. An analytic study found that menstruation was significantly associated with ISRR (AOR = 6.84 [95%CI = 1.09–42.91]). The environmental survey suggested that the cold chain system was properly managed. Further studies on other precipitating causes of ISRR should be performed. In terms of recommendation, health providers should pay greater attention to women menstruating during and after COVID-19 immunization. |
| first_indexed | 2024-03-09T12:19:07Z |
| format | Article |
| id | doaj.art-b1d735b3b48a4fb49347a1b9a02f9db2 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T12:19:07Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-b1d735b3b48a4fb49347a1b9a02f9db22023-11-30T22:42:59ZengMDPI AGVaccines2076-393X2022-03-0110344110.3390/vaccines10030441Investigation of a Cluster of Immunization Stress-Related Reactions after Coronavirus Disease 2019 (COVID-19) Vaccination, Thailand, 2021Chayanit Mahasing0Oiythip Yasopa1Chalo Sansilapin2Thanit Rattanathumsakul3Panithee Thammawijaya4Rapeepong Suphanchaimat5Pawinee Doung-ngern6Division of Epidemiology, Department of Disease Control, Ministry of Public Health, Nonthaburi 11000, ThailandDivision of Epidemiology, Department of Disease Control, Ministry of Public Health, Nonthaburi 11000, ThailandDivision of Epidemiology, Department of Disease Control, Ministry of Public Health, Nonthaburi 11000, ThailandDivision of Epidemiology, Department of Disease Control, Ministry of Public Health, Nonthaburi 11000, ThailandDivision of Epidemiology, Department of Disease Control, Ministry of Public Health, Nonthaburi 11000, ThailandDivision of Epidemiology, Department of Disease Control, Ministry of Public Health, Nonthaburi 11000, ThailandDivision of Epidemiology, Department of Disease Control, Ministry of Public Health, Nonthaburi 11000, ThailandOn 28 April 2021, the investigation team of the Department of Disease Control, Ministry of Public Health, was notified of a cluster of people developing neurological symptoms following COVID-19 vaccination in a province in eastern Thailand. We conducted an investigation from 29 April to 20 May 2021 to confirm the outbreak, describe the epidemiological characteristics and identify possible risk factors. A matched case-control study was conducted. Matching factors were gender and vaccination site. A confirmed case was a person receiving COVID-19 vaccination in the province and developed at least one neurological symptom between 21 April and 20 May 2021. The rapid assessment of the vaccination cold chain system was carried out. We found a total of 36 cases out of 3920 vaccinees (attack rate = 0.92%), all cases were recovered and classified as an immunization stress-related reaction (ISRR) by the National AEFI Expert Committee. An analytic study found that menstruation was significantly associated with ISRR (AOR = 6.84 [95%CI = 1.09–42.91]). The environmental survey suggested that the cold chain system was properly managed. Further studies on other precipitating causes of ISRR should be performed. In terms of recommendation, health providers should pay greater attention to women menstruating during and after COVID-19 immunization.https://www.mdpi.com/2076-393X/10/3/441adverse event following immunizationimmunization stress-related reactionCOVID-19 vaccinationCoronaVac |
| spellingShingle | Chayanit Mahasing Oiythip Yasopa Chalo Sansilapin Thanit Rattanathumsakul Panithee Thammawijaya Rapeepong Suphanchaimat Pawinee Doung-ngern Investigation of a Cluster of Immunization Stress-Related Reactions after Coronavirus Disease 2019 (COVID-19) Vaccination, Thailand, 2021 Vaccines adverse event following immunization immunization stress-related reaction COVID-19 vaccination CoronaVac |
| title | Investigation of a Cluster of Immunization Stress-Related Reactions after Coronavirus Disease 2019 (COVID-19) Vaccination, Thailand, 2021 |
| title_full | Investigation of a Cluster of Immunization Stress-Related Reactions after Coronavirus Disease 2019 (COVID-19) Vaccination, Thailand, 2021 |
| title_fullStr | Investigation of a Cluster of Immunization Stress-Related Reactions after Coronavirus Disease 2019 (COVID-19) Vaccination, Thailand, 2021 |
| title_full_unstemmed | Investigation of a Cluster of Immunization Stress-Related Reactions after Coronavirus Disease 2019 (COVID-19) Vaccination, Thailand, 2021 |
| title_short | Investigation of a Cluster of Immunization Stress-Related Reactions after Coronavirus Disease 2019 (COVID-19) Vaccination, Thailand, 2021 |
| title_sort | investigation of a cluster of immunization stress related reactions after coronavirus disease 2019 covid 19 vaccination thailand 2021 |
| topic | adverse event following immunization immunization stress-related reaction COVID-19 vaccination CoronaVac |
| url | https://www.mdpi.com/2076-393X/10/3/441 |
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