Overexpression of GATA1 confers resistance to chemotherapy in acute megakaryocytic Leukemia.

Overexpression of GATA1 confers resistance to chemotherapy in acute megakaryocytic Leukemia.

It has been previously shown that acute myeloid leukemia (AML) patients with higher levels of GATA1 expression have poorer outcomes. Furthermore, pediatric Down syndrome (DS) patients with acute megakaryocytic leukemia (AMKL), whose blast cells almost universally harbor somatic mutations in exon 2 o...

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Bibliographic Details
Main Authors: John Timothy Caldwell, Holly Edwards, Alan A Dombkowski, Steven A Buck, Larry H Matherly, Yubin Ge, Jeffrey W Taub
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3707876?pdf=render

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