Hyperalgesia, Increased Temporal Summation and Impaired Inhibitory Mechanisms in Episodic and Chronic Cluster Headache: An Observational Study
Cluster Headache (CH) is a primary headache that causes severe pain. Some evidence suggests that central mechanisms might be involved. The objective of this study was (1) to compare hyperalgesia signs, temporal summation and conditioned pain modulation among episodic (ECH) and chronic CH (CCH) patie...
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MDPI AG
2024-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/2/374 |
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| author | Gabriele Bertotti Juan Ignacio Elizagaray-García Jaime Rodríguez-Vico Alfonso Gil-Martínez |
| author_facet | Gabriele Bertotti Juan Ignacio Elizagaray-García Jaime Rodríguez-Vico Alfonso Gil-Martínez |
| author_sort | Gabriele Bertotti |
| collection | DOAJ |
| description | Cluster Headache (CH) is a primary headache that causes severe pain. Some evidence suggests that central mechanisms might be involved. The objective of this study was (1) to compare hyperalgesia signs, temporal summation and conditioned pain modulation among episodic (ECH) and chronic CH (CCH) patients and controls, (2) to compare these factors between sides in the patient groups and (3) to compare the psychophysical variables between the groups. This cross-sectional study included 71 subjects divided into three groups (ECH, CCH and controls). Pressure pain thresholds, temporal summation, conditioned pain modulation and other psychosocial variables were measured. The ANOVA showed differences for all physical outcome measures (<i>p</i> < 0.05). Bonferroni post hoc analyses showed differences when comparing the patient groups with the healthy subjects (<i>p</i> < 0.05), with large effect sizes (<i>d</i> > 0.8). No differences between the patient groups were found for almost all the variables (<i>p</i> > 0.05). Significant differences for all the variables were detected when comparing the symptomatic and non-symptomatic sides in both the ECH and CCH groups (<i>p</i> < 0.05). The ECH and CCH groups showed mechanical hyperalgesia, increased temporal summation and impaired inhibitory mechanisms compared to the controls. Side-to-side differences were also detected within the patient groups. Patients with CCH had poorer sleep quality and quality of life than the controls. |
| first_indexed | 2024-03-07T22:40:56Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-07T22:40:56Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-b1d79373a73f43edaabcbeb25fbb88432024-02-23T15:08:39ZengMDPI AGBiomedicines2227-90592024-02-0112237410.3390/biomedicines12020374Hyperalgesia, Increased Temporal Summation and Impaired Inhibitory Mechanisms in Episodic and Chronic Cluster Headache: An Observational StudyGabriele Bertotti0Juan Ignacio Elizagaray-García1Jaime Rodríguez-Vico2Alfonso Gil-Martínez3School of Physiotherapy, Faculty of Health Sciences, Universidad Francisco de Vitoria, 28223 Madrid, SpainCranioSPain Research Group, Centro Superior de Estudios Universitarios La Salle, Universidad Autónoma de Madrid, 28023 Madrid, SpainHeadache Unit, Neurology Department, Hospital Universitario Fundación Jiménez Díaz, 28040 Madrid, SpainCranioSPain Research Group, Centro Superior de Estudios Universitarios La Salle, Universidad Autónoma de Madrid, 28023 Madrid, SpainCluster Headache (CH) is a primary headache that causes severe pain. Some evidence suggests that central mechanisms might be involved. The objective of this study was (1) to compare hyperalgesia signs, temporal summation and conditioned pain modulation among episodic (ECH) and chronic CH (CCH) patients and controls, (2) to compare these factors between sides in the patient groups and (3) to compare the psychophysical variables between the groups. This cross-sectional study included 71 subjects divided into three groups (ECH, CCH and controls). Pressure pain thresholds, temporal summation, conditioned pain modulation and other psychosocial variables were measured. The ANOVA showed differences for all physical outcome measures (<i>p</i> < 0.05). Bonferroni post hoc analyses showed differences when comparing the patient groups with the healthy subjects (<i>p</i> < 0.05), with large effect sizes (<i>d</i> > 0.8). No differences between the patient groups were found for almost all the variables (<i>p</i> > 0.05). Significant differences for all the variables were detected when comparing the symptomatic and non-symptomatic sides in both the ECH and CCH groups (<i>p</i> < 0.05). The ECH and CCH groups showed mechanical hyperalgesia, increased temporal summation and impaired inhibitory mechanisms compared to the controls. Side-to-side differences were also detected within the patient groups. Patients with CCH had poorer sleep quality and quality of life than the controls.https://www.mdpi.com/2227-9059/12/2/374cluster headachecentral sensitizationhyperalgesiatemporal summationconditioned pain modulation |
| spellingShingle | Gabriele Bertotti Juan Ignacio Elizagaray-García Jaime Rodríguez-Vico Alfonso Gil-Martínez Hyperalgesia, Increased Temporal Summation and Impaired Inhibitory Mechanisms in Episodic and Chronic Cluster Headache: An Observational Study Biomedicines cluster headache central sensitization hyperalgesia temporal summation conditioned pain modulation |
| title | Hyperalgesia, Increased Temporal Summation and Impaired Inhibitory Mechanisms in Episodic and Chronic Cluster Headache: An Observational Study |
| title_full | Hyperalgesia, Increased Temporal Summation and Impaired Inhibitory Mechanisms in Episodic and Chronic Cluster Headache: An Observational Study |
| title_fullStr | Hyperalgesia, Increased Temporal Summation and Impaired Inhibitory Mechanisms in Episodic and Chronic Cluster Headache: An Observational Study |
| title_full_unstemmed | Hyperalgesia, Increased Temporal Summation and Impaired Inhibitory Mechanisms in Episodic and Chronic Cluster Headache: An Observational Study |
| title_short | Hyperalgesia, Increased Temporal Summation and Impaired Inhibitory Mechanisms in Episodic and Chronic Cluster Headache: An Observational Study |
| title_sort | hyperalgesia increased temporal summation and impaired inhibitory mechanisms in episodic and chronic cluster headache an observational study |
| topic | cluster headache central sensitization hyperalgesia temporal summation conditioned pain modulation |
| url | https://www.mdpi.com/2227-9059/12/2/374 |
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