Analysis of clinical data and T helper 1/T helper 2 responses in patients with different clinical forms of leprosy
Abstract INTRODUCTION: Currently, there are no laboratory tests or sensitive and specific molecular markers for the early diagnosis of leprosy. The aim of this study was to analyze the clinical characteristics of patients with leprosy and investigate their immunological profile, comparing this with...
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Sociedade Brasileira de Medicina Tropical (SBMT)
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000200208&lng=en&tlng=en |
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| author | Ricardo Wilson de Pinho Rodrigues Afonso Bezerra Ribeiro Gilcele de Campos Martin Berber LeeYun Sheng Amilcar Sabino Damazo |
| author_facet | Ricardo Wilson de Pinho Rodrigues Afonso Bezerra Ribeiro Gilcele de Campos Martin Berber LeeYun Sheng Amilcar Sabino Damazo |
| author_sort | Ricardo Wilson de Pinho Rodrigues |
| collection | DOAJ |
| description | Abstract INTRODUCTION: Currently, there are no laboratory tests or sensitive and specific molecular markers for the early diagnosis of leprosy. The aim of this study was to analyze the clinical characteristics of patients with leprosy and investigate their immunological profile, comparing this with the type of lesion and the presence or absence of a Bacillus Calmette-Guérin (BCG) vaccination scar. METHODS: Statistical analyzes were performed by employing comparative tests (Pearson´s chi-square) to evaluate the variables in different clinical forms, considering significance at the 5% level. RESULTS: The study identified a predominance of lepromatous leprosy (26.9%) in patients aged between 34-53 years. Caucasians predominantly had borderline tuberculoid (BT) clinical forms (42%); a predominance of males with borderline lepromatous (19%) and lepromatous leprosy (26.9%) forms was observed; and the presence of BCG vaccination scars (27.5%) and lower limb nerves were more affected (38%) predominantly in the BT clinical form. Significant differences were identified, which included hypochromic lesions predominantly in the BT clinical form (24%); diffuse-type lesions predominantly in the tuberculoid (TT) clinical form (28%); ill-defined lesion border dominance in lepromatous leprosy (LL) clinical forms (30%); an irregular lesion limit predominantly in LL clinical forms (32%); and a predominant Th1 immune response in the BT clinical form (41.7%). CONCLUSIONS: The evaluation of the immunological profile in leprosy patients may contribute to the more detailed diagnosis and possibly better characterization of the prognosis for these individuals. |
| first_indexed | 2024-12-12T12:24:07Z |
| format | Article |
| id | doaj.art-b1d805d8a7f14713a483eeacd8c32929 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-12-12T12:24:07Z |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-b1d805d8a7f14713a483eeacd8c329292022-12-22T00:24:36ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-984950220821510.1590/0037-8682-0426-2016S0037-86822017000200208Analysis of clinical data and T helper 1/T helper 2 responses in patients with different clinical forms of leprosyRicardo Wilson de Pinho RodriguesAfonso Bezerra RibeiroGilcele de Campos Martin BerberLeeYun ShengAmilcar Sabino DamazoAbstract INTRODUCTION: Currently, there are no laboratory tests or sensitive and specific molecular markers for the early diagnosis of leprosy. The aim of this study was to analyze the clinical characteristics of patients with leprosy and investigate their immunological profile, comparing this with the type of lesion and the presence or absence of a Bacillus Calmette-Guérin (BCG) vaccination scar. METHODS: Statistical analyzes were performed by employing comparative tests (Pearson´s chi-square) to evaluate the variables in different clinical forms, considering significance at the 5% level. RESULTS: The study identified a predominance of lepromatous leprosy (26.9%) in patients aged between 34-53 years. Caucasians predominantly had borderline tuberculoid (BT) clinical forms (42%); a predominance of males with borderline lepromatous (19%) and lepromatous leprosy (26.9%) forms was observed; and the presence of BCG vaccination scars (27.5%) and lower limb nerves were more affected (38%) predominantly in the BT clinical form. Significant differences were identified, which included hypochromic lesions predominantly in the BT clinical form (24%); diffuse-type lesions predominantly in the tuberculoid (TT) clinical form (28%); ill-defined lesion border dominance in lepromatous leprosy (LL) clinical forms (30%); an irregular lesion limit predominantly in LL clinical forms (32%); and a predominant Th1 immune response in the BT clinical form (41.7%). CONCLUSIONS: The evaluation of the immunological profile in leprosy patients may contribute to the more detailed diagnosis and possibly better characterization of the prognosis for these individuals.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000200208&lng=en&tlng=enMycobacterium lepraeEpidemiologyTh1/Th2 responseTuberculoidLepromatous |
| spellingShingle | Ricardo Wilson de Pinho Rodrigues Afonso Bezerra Ribeiro Gilcele de Campos Martin Berber LeeYun Sheng Amilcar Sabino Damazo Analysis of clinical data and T helper 1/T helper 2 responses in patients with different clinical forms of leprosy Revista da Sociedade Brasileira de Medicina Tropical Mycobacterium leprae Epidemiology Th1/Th2 response Tuberculoid Lepromatous |
| title | Analysis of clinical data and T helper 1/T helper 2 responses in patients with different clinical forms of leprosy |
| title_full | Analysis of clinical data and T helper 1/T helper 2 responses in patients with different clinical forms of leprosy |
| title_fullStr | Analysis of clinical data and T helper 1/T helper 2 responses in patients with different clinical forms of leprosy |
| title_full_unstemmed | Analysis of clinical data and T helper 1/T helper 2 responses in patients with different clinical forms of leprosy |
| title_short | Analysis of clinical data and T helper 1/T helper 2 responses in patients with different clinical forms of leprosy |
| title_sort | analysis of clinical data and t helper 1 t helper 2 responses in patients with different clinical forms of leprosy |
| topic | Mycobacterium leprae Epidemiology Th1/Th2 response Tuberculoid Lepromatous |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000200208&lng=en&tlng=en |
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