High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed?
In August 2022, Indonesia prioritized healthcare workers to receive the second booster dose. We conducted a sequential serosurvey to understand the dynamics of the antibody titers. The first serosurvey, which was conducted in June 2021, 1–6 months after Sinovac vaccination, showed a median antibody...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
|
| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/11/8/1300 |
| _version_ | 1827728573930143744 |
|---|---|
| author | Amila Hanifan Muslimah Marita Restie Tiara Hofiya Djauhari Muhammad Hafizh Dewantara Evan Susandi Agnes Rengga Indrati Bachti Alisjahbana Arto Yuwono Soeroto Rudi Wisaksana |
| author_facet | Amila Hanifan Muslimah Marita Restie Tiara Hofiya Djauhari Muhammad Hafizh Dewantara Evan Susandi Agnes Rengga Indrati Bachti Alisjahbana Arto Yuwono Soeroto Rudi Wisaksana |
| author_sort | Amila Hanifan Muslimah |
| collection | DOAJ |
| description | In August 2022, Indonesia prioritized healthcare workers to receive the second booster dose. We conducted a sequential serosurvey to understand the dynamics of the antibody titers. The first serosurvey, which was conducted in June 2021, 1–6 months after Sinovac vaccination, showed a median antibody level of 41.4 BAU/mL (interquartile range (IQR): 10–629.4 BAU/mL). The second serosurvey was conducted one month (August 2021) after the first Moderna booster vaccine and showed a median level of 4000 BAU/mL (IQR: 3081–4000 BAU/mL). The last serosurvey was conducted a year (August 2022) after the booster and showed a median level of 4000 BAU/mL (IQR: 4000–4000 BAU/mL). In this last survey, only 39 (11.9%) of healthcare workers had antibody levels below the maximum level of 4000 BAU/mL. Thus, one year after the first booster dose, we did not observe the waning of antibody levels. The average increase was perhaps because of natural infection. Based on these considerations, we believe that a second booster dose was not necessary for this category of subjects at that time. Because vaccine supply is often limited, priority could be given to the general population or other high-risk patient groups with low antibody titers based on serological tests. |
| first_indexed | 2024-03-10T23:31:56Z |
| format | Article |
| id | doaj.art-b1d83eba710749c5acd4ae7536ac871d |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T23:31:56Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-b1d83eba710749c5acd4ae7536ac871d2023-11-19T03:17:09ZengMDPI AGVaccines2076-393X2023-07-01118130010.3390/vaccines11081300High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed?Amila Hanifan Muslimah0Marita Restie Tiara1Hofiya Djauhari2Muhammad Hafizh Dewantara3Evan Susandi4Agnes Rengga Indrati5Bachti Alisjahbana6Arto Yuwono Soeroto7Rudi Wisaksana8Department of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, IndonesiaResearch Center for Care and Control of Infectious Disease, Universitas Padjadjaran, Bandung 40161, IndonesiaResearch Center for Care and Control of Infectious Disease, Universitas Padjadjaran, Bandung 40161, IndonesiaDepartment of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, IndonesiaDepartment of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, IndonesiaDepartment of Clinical Pathology, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, IndonesiaDepartment of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, IndonesiaDepartment of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, IndonesiaDepartment of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, IndonesiaIn August 2022, Indonesia prioritized healthcare workers to receive the second booster dose. We conducted a sequential serosurvey to understand the dynamics of the antibody titers. The first serosurvey, which was conducted in June 2021, 1–6 months after Sinovac vaccination, showed a median antibody level of 41.4 BAU/mL (interquartile range (IQR): 10–629.4 BAU/mL). The second serosurvey was conducted one month (August 2021) after the first Moderna booster vaccine and showed a median level of 4000 BAU/mL (IQR: 3081–4000 BAU/mL). The last serosurvey was conducted a year (August 2022) after the booster and showed a median level of 4000 BAU/mL (IQR: 4000–4000 BAU/mL). In this last survey, only 39 (11.9%) of healthcare workers had antibody levels below the maximum level of 4000 BAU/mL. Thus, one year after the first booster dose, we did not observe the waning of antibody levels. The average increase was perhaps because of natural infection. Based on these considerations, we believe that a second booster dose was not necessary for this category of subjects at that time. Because vaccine supply is often limited, priority could be given to the general population or other high-risk patient groups with low antibody titers based on serological tests.https://www.mdpi.com/2076-393X/11/8/1300antibodyCOVID-19 vaccinationhealthcare worker |
| spellingShingle | Amila Hanifan Muslimah Marita Restie Tiara Hofiya Djauhari Muhammad Hafizh Dewantara Evan Susandi Agnes Rengga Indrati Bachti Alisjahbana Arto Yuwono Soeroto Rudi Wisaksana High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed? Vaccines antibody COVID-19 vaccination healthcare worker |
| title | High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed? |
| title_full | High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed? |
| title_fullStr | High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed? |
| title_full_unstemmed | High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed? |
| title_short | High Levels of Anti-SARS-CoV-2 Receptor-Binding Domain (RBD) Antibodies One Year Post Booster Vaccinations among Hospital Workers in Indonesia: Was the Second Booster Needed? |
| title_sort | high levels of anti sars cov 2 receptor binding domain rbd antibodies one year post booster vaccinations among hospital workers in indonesia was the second booster needed |
| topic | antibody COVID-19 vaccination healthcare worker |
| url | https://www.mdpi.com/2076-393X/11/8/1300 |
| work_keys_str_mv | AT amilahanifanmuslimah highlevelsofantisarscov2receptorbindingdomainrbdantibodiesoneyearpostboostervaccinationsamonghospitalworkersinindonesiawasthesecondboosterneeded AT maritarestietiara highlevelsofantisarscov2receptorbindingdomainrbdantibodiesoneyearpostboostervaccinationsamonghospitalworkersinindonesiawasthesecondboosterneeded AT hofiyadjauhari highlevelsofantisarscov2receptorbindingdomainrbdantibodiesoneyearpostboostervaccinationsamonghospitalworkersinindonesiawasthesecondboosterneeded AT muhammadhafizhdewantara highlevelsofantisarscov2receptorbindingdomainrbdantibodiesoneyearpostboostervaccinationsamonghospitalworkersinindonesiawasthesecondboosterneeded AT evansusandi highlevelsofantisarscov2receptorbindingdomainrbdantibodiesoneyearpostboostervaccinationsamonghospitalworkersinindonesiawasthesecondboosterneeded AT agnesrenggaindrati highlevelsofantisarscov2receptorbindingdomainrbdantibodiesoneyearpostboostervaccinationsamonghospitalworkersinindonesiawasthesecondboosterneeded AT bachtialisjahbana highlevelsofantisarscov2receptorbindingdomainrbdantibodiesoneyearpostboostervaccinationsamonghospitalworkersinindonesiawasthesecondboosterneeded AT artoyuwonosoeroto highlevelsofantisarscov2receptorbindingdomainrbdantibodiesoneyearpostboostervaccinationsamonghospitalworkersinindonesiawasthesecondboosterneeded AT rudiwisaksana highlevelsofantisarscov2receptorbindingdomainrbdantibodiesoneyearpostboostervaccinationsamonghospitalworkersinindonesiawasthesecondboosterneeded |