Correlation between Collagen Type I/III Ratio and Scar Formation in Patients Undergoing Immediate Reconstruction with the Round Block Technique after Breast-Conserving Surgery
The aim of this study was to investigate the relationship between the collagen type I/III ratio and scarring in patients who underwent immediate reconstruction with the round block technique (RBT) after breast conservation surgery. Seventy-eight patients were included, and demographic and clinical c...
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MDPI AG
2023-04-01
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| Online Access: | https://www.mdpi.com/2227-9059/11/4/1089 |
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| author | Hyo-young Kim Ho-young Im Hee-kyung Chang Hwan-do Jeong Jin-hyung Park Hong-il Kim Hyung-suk Yi Yoon-soo Kim |
| author_facet | Hyo-young Kim Ho-young Im Hee-kyung Chang Hwan-do Jeong Jin-hyung Park Hong-il Kim Hyung-suk Yi Yoon-soo Kim |
| author_sort | Hyo-young Kim |
| collection | DOAJ |
| description | The aim of this study was to investigate the relationship between the collagen type I/III ratio and scarring in patients who underwent immediate reconstruction with the round block technique (RBT) after breast conservation surgery. Seventy-eight patients were included, and demographic and clinical characteristics were recorded. The collagen type I/III ratio was measured using immunofluorescence staining and digital imaging, and scarring was assessed using the Vancouver Scar Scale (VSS). The mean VSS scores were 1.92 ± 2.01 and 1.79 ± 1.89, as assessed by two independent plastic surgeons, with good reliability of the scores. A significant positive correlation was found between VSS and the collagen type I/III ratio (r = 0.552, <i>p</i> < 0.01), and a significant negative correlation was found between VSS and the collagen type III content (r = −0.326, <i>p</i> < 0.05). Multiple linear regression analysis showed that the collagen type I/III ratio had a significant positive effect on VSS (β = 0.415, <i>p</i> = 0.028), whereas the collagen type I and collagen type III content had no significant effect on VSS. These findings suggest that the collagen type I/III ratio is associated with scar development in patients undergoing RBT after breast conservation surgery. Further research is needed to develop a patient-specific scar prediction model based on genetic factors affecting the collagen type I/III ratio. |
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| publishDate | 2023-04-01 |
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| series | Biomedicines |
| spelling | doaj.art-b1d9054084914201be64b7497e5e13bc2023-11-17T18:26:23ZengMDPI AGBiomedicines2227-90592023-04-01114108910.3390/biomedicines11041089Correlation between Collagen Type I/III Ratio and Scar Formation in Patients Undergoing Immediate Reconstruction with the Round Block Technique after Breast-Conserving SurgeryHyo-young Kim0Ho-young Im1Hee-kyung Chang2Hwan-do Jeong3Jin-hyung Park4Hong-il Kim5Hyung-suk Yi6Yoon-soo Kim7We Are the Plastic Surgery, 415, Haeun-daero, Haeundae-gu, Busan 48064, Republic of KoreaDepartment of Plastic and Reconstructive Surgery, College of Medicine, Kosin University, 262, Seo-gu, Busan 49267, Republic of KoreaDepartment of Pathology, College of Medicine, Kosin University, 262, Seo-gu, Busan 49267, Republic of KoreaKosin Innovative Smart Healthcare Research Center, Kosin University Gospel Hospital, 262, Seo-gu, Busan 49267, Republic of KoreaDepartment of Plastic and Reconstructive Surgery, College of Medicine, Kosin University, 262, Seo-gu, Busan 49267, Republic of KoreaDepartment of Plastic and Reconstructive Surgery, College of Medicine, Kosin University, 262, Seo-gu, Busan 49267, Republic of KoreaDepartment of Plastic and Reconstructive Surgery, College of Medicine, Kosin University, 262, Seo-gu, Busan 49267, Republic of KoreaDepartment of Plastic and Reconstructive Surgery, College of Medicine, Kosin University, 262, Seo-gu, Busan 49267, Republic of KoreaThe aim of this study was to investigate the relationship between the collagen type I/III ratio and scarring in patients who underwent immediate reconstruction with the round block technique (RBT) after breast conservation surgery. Seventy-eight patients were included, and demographic and clinical characteristics were recorded. The collagen type I/III ratio was measured using immunofluorescence staining and digital imaging, and scarring was assessed using the Vancouver Scar Scale (VSS). The mean VSS scores were 1.92 ± 2.01 and 1.79 ± 1.89, as assessed by two independent plastic surgeons, with good reliability of the scores. A significant positive correlation was found between VSS and the collagen type I/III ratio (r = 0.552, <i>p</i> < 0.01), and a significant negative correlation was found between VSS and the collagen type III content (r = −0.326, <i>p</i> < 0.05). Multiple linear regression analysis showed that the collagen type I/III ratio had a significant positive effect on VSS (β = 0.415, <i>p</i> = 0.028), whereas the collagen type I and collagen type III content had no significant effect on VSS. These findings suggest that the collagen type I/III ratio is associated with scar development in patients undergoing RBT after breast conservation surgery. Further research is needed to develop a patient-specific scar prediction model based on genetic factors affecting the collagen type I/III ratio.https://www.mdpi.com/2227-9059/11/4/1089breast-conserving surgerycollagen type Icollagen type IIIVancouver Scar Scale |
| spellingShingle | Hyo-young Kim Ho-young Im Hee-kyung Chang Hwan-do Jeong Jin-hyung Park Hong-il Kim Hyung-suk Yi Yoon-soo Kim Correlation between Collagen Type I/III Ratio and Scar Formation in Patients Undergoing Immediate Reconstruction with the Round Block Technique after Breast-Conserving Surgery Biomedicines breast-conserving surgery collagen type I collagen type III Vancouver Scar Scale |
| title | Correlation between Collagen Type I/III Ratio and Scar Formation in Patients Undergoing Immediate Reconstruction with the Round Block Technique after Breast-Conserving Surgery |
| title_full | Correlation between Collagen Type I/III Ratio and Scar Formation in Patients Undergoing Immediate Reconstruction with the Round Block Technique after Breast-Conserving Surgery |
| title_fullStr | Correlation between Collagen Type I/III Ratio and Scar Formation in Patients Undergoing Immediate Reconstruction with the Round Block Technique after Breast-Conserving Surgery |
| title_full_unstemmed | Correlation between Collagen Type I/III Ratio and Scar Formation in Patients Undergoing Immediate Reconstruction with the Round Block Technique after Breast-Conserving Surgery |
| title_short | Correlation between Collagen Type I/III Ratio and Scar Formation in Patients Undergoing Immediate Reconstruction with the Round Block Technique after Breast-Conserving Surgery |
| title_sort | correlation between collagen type i iii ratio and scar formation in patients undergoing immediate reconstruction with the round block technique after breast conserving surgery |
| topic | breast-conserving surgery collagen type I collagen type III Vancouver Scar Scale |
| url | https://www.mdpi.com/2227-9059/11/4/1089 |
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