The Signaling Pathways Induced by Exosomes in Promoting Diabetic Wound Healing: A Mini-Review
Impaired healing of diabetic wounds harms patients’ quality of life and even leads to disability and death, which is an urgent issue to be solved clinically. Despite the great progress that has been achieved, it remains a worldwide challenge to develop effective therapeutic treatments for diabetic w...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/44/10/337 |
| _version_ | 1827650905417187328 |
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| author | Yanying Wang Jiayan Zhu Jing Chen Ruojiao Xu Thomas Groth Haitong Wan Guoying Zhou |
| author_facet | Yanying Wang Jiayan Zhu Jing Chen Ruojiao Xu Thomas Groth Haitong Wan Guoying Zhou |
| author_sort | Yanying Wang |
| collection | DOAJ |
| description | Impaired healing of diabetic wounds harms patients’ quality of life and even leads to disability and death, which is an urgent issue to be solved clinically. Despite the great progress that has been achieved, it remains a worldwide challenge to develop effective therapeutic treatments for diabetic wounds. Recently, exosomes have attracted special attention because they can be involved in immune response, antigen presentation, cell migration, cell differentiation, tumor invasion and other processes. Meanwhile, exosomes have been proven to hold great potential in the treatment of diabetic wounds. Mechanistic studies of exosomes based on signaling pathways could not only help to uncover the mechanisms by which exosomes promote diabetic wound healing but could also provide a theoretical basis for the clinical application of exosomes. Herein, our mini-review aims to summarize the progress of research on the use of various exosomes derived from different cell types to promote diabetic wound healing, with a focus on the classical signaling pathways, including PI3K/Akt, Wnt, NF-κB, MAPK, Notch, Nrf2, HIF-1α/VEGF and TGF-β/Smad. The results show that exosomes could regulate these signaling pathways to down-regulate inflammation, reduce oxidative stress, increase angiogenesis, promote fibroblast proliferation, induce re-epithelization and inhibit scar formation, making exosomes attractive candidates for the treatment of diabetic wounds. |
| first_indexed | 2024-03-09T20:26:28Z |
| format | Article |
| id | doaj.art-b1d9f8ccb2534a26b509ece842c47a6d |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-09T20:26:28Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-b1d9f8ccb2534a26b509ece842c47a6d2023-11-23T23:34:14ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452022-10-0144104960497610.3390/cimb44100337The Signaling Pathways Induced by Exosomes in Promoting Diabetic Wound Healing: A Mini-ReviewYanying Wang0Jiayan Zhu1Jing Chen2Ruojiao Xu3Thomas Groth4Haitong Wan5Guoying Zhou6The Second Clinical Medical College, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, ChinaCollege of Life Science, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, ChinaCollege of Life Science, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, ChinaCollege of Life Science, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, ChinaDepartment Biomedical Materials, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, D-06099 Halle (Saale), GermanyCollege of Life Science, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, ChinaThe Second Clinical Medical College, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou 310053, ChinaImpaired healing of diabetic wounds harms patients’ quality of life and even leads to disability and death, which is an urgent issue to be solved clinically. Despite the great progress that has been achieved, it remains a worldwide challenge to develop effective therapeutic treatments for diabetic wounds. Recently, exosomes have attracted special attention because they can be involved in immune response, antigen presentation, cell migration, cell differentiation, tumor invasion and other processes. Meanwhile, exosomes have been proven to hold great potential in the treatment of diabetic wounds. Mechanistic studies of exosomes based on signaling pathways could not only help to uncover the mechanisms by which exosomes promote diabetic wound healing but could also provide a theoretical basis for the clinical application of exosomes. Herein, our mini-review aims to summarize the progress of research on the use of various exosomes derived from different cell types to promote diabetic wound healing, with a focus on the classical signaling pathways, including PI3K/Akt, Wnt, NF-κB, MAPK, Notch, Nrf2, HIF-1α/VEGF and TGF-β/Smad. The results show that exosomes could regulate these signaling pathways to down-regulate inflammation, reduce oxidative stress, increase angiogenesis, promote fibroblast proliferation, induce re-epithelization and inhibit scar formation, making exosomes attractive candidates for the treatment of diabetic wounds.https://www.mdpi.com/1467-3045/44/10/337exosomesdiabetic wound healingmechanismsignaling pathwaydiabetic foot ulcer |
| spellingShingle | Yanying Wang Jiayan Zhu Jing Chen Ruojiao Xu Thomas Groth Haitong Wan Guoying Zhou The Signaling Pathways Induced by Exosomes in Promoting Diabetic Wound Healing: A Mini-Review Current Issues in Molecular Biology exosomes diabetic wound healing mechanism signaling pathway diabetic foot ulcer |
| title | The Signaling Pathways Induced by Exosomes in Promoting Diabetic Wound Healing: A Mini-Review |
| title_full | The Signaling Pathways Induced by Exosomes in Promoting Diabetic Wound Healing: A Mini-Review |
| title_fullStr | The Signaling Pathways Induced by Exosomes in Promoting Diabetic Wound Healing: A Mini-Review |
| title_full_unstemmed | The Signaling Pathways Induced by Exosomes in Promoting Diabetic Wound Healing: A Mini-Review |
| title_short | The Signaling Pathways Induced by Exosomes in Promoting Diabetic Wound Healing: A Mini-Review |
| title_sort | signaling pathways induced by exosomes in promoting diabetic wound healing a mini review |
| topic | exosomes diabetic wound healing mechanism signaling pathway diabetic foot ulcer |
| url | https://www.mdpi.com/1467-3045/44/10/337 |
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