Watson‐Crick Base Pairing of N‐Methoxy‐1,3‐Oxazinane (MOANA) Nucleoside Analogues within Double‐Helical DNA

Watson‐Crick Base Pairing of N‐Methoxy‐1,3‐Oxazinane (MOANA) Nucleoside Analogues within Double‐Helical DNA

Abstract Hairpin oligodeoxynucleotides incorporating a (2R,3S)‐4‐(methoxyamino)butane‐1,2,3‐triol residue in the middle of the double‐helical stem and opposite to either one of the canonical nucleobases or an abasic 2‐(hydroxymethyl)tetrahydrofuran‐3‐ol spacer were synthesized. Under mildly acidic c...

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Bibliographic Details
Main Authors: Mark N. K. Afari, Kasper Nurmi, Prof. Pasi Virta, Prof. Tuomas Lönnberg
Format: Article
Language:English
Published: Wiley-VCH 2023-07-01
Series:ChemistryOpen
Subjects:
base pairing
DNA-templated ligation
dynamic base filling
oligonucleotides
oxazinanes
Online Access:https://doi.org/10.1002/open.202300085

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