Duration of Diabetes as a Risk Factor for Retinal Microvasculature Alterations Detected with Optical Coherence Tomography Angiography in Patients without Clinical Retinopathy
In this study, we examined the impact of diabetes mellitus (DM) disease duration on optical coherence tomography angiography (OCTA) parameters in diabetic patients without diabetic retinopathy (DR). A total of 1118 eyes from 1118 DM patients without DR were divided into three groups by DM duration:...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/12/3020 |
| _version_ | 1797460689593303040 |
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| author | Jing Qian Zeeshan Haq Daphne Yang Joy Q. Jin Jay M. Stewart |
| author_facet | Jing Qian Zeeshan Haq Daphne Yang Joy Q. Jin Jay M. Stewart |
| author_sort | Jing Qian |
| collection | DOAJ |
| description | In this study, we examined the impact of diabetes mellitus (DM) disease duration on optical coherence tomography angiography (OCTA) parameters in diabetic patients without diabetic retinopathy (DR). A total of 1118 eyes from 1118 DM patients without DR were divided into three groups by DM duration: 0–5 years (short cohort; <i>n</i> = 571), 6–10 years (medium cohort; <i>n</i> = 306), and >10 years (long cohort; <i>n</i> = 241). Ultra-widefield fundus photography and nine OCTA parameters derived from the superficial retinal capillary plexus were analyzed. Perfusion density (PD) and vessel length density (VD) were significantly decreased within the 1 mm patch in patient OCTAs from the medium cohort compared to the short cohort. Conversely, PD and VD were significantly decreased within the 6 mm patch and inner ring among the long cohort compared to the short and medium cohorts. These findings remained consistent after controlled analysis. Patients in the medium cohort had the largest FAZ area, while patients in the long cohort had the smallest FAZ area, with a statistically significant difference between the two groups. Superficial PD and VD significantly decreased among the medium and long cohorts compared to the short cohort, confirming that subclinical, progressive macular vasculature change is associated with longer DM duration. However, while FAZ area significantly increased in the medium cohort, the long cohort exhibited decreased FAZ area, suggesting the latter may possess protective factors that decrease overall risk of DR development. |
| first_indexed | 2024-03-09T17:08:37Z |
| format | Article |
| id | doaj.art-b1da8188865b4b73bf2e5d3410588fa5 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T17:08:37Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-b1da8188865b4b73bf2e5d3410588fa52023-11-24T14:17:15ZengMDPI AGDiagnostics2075-44182022-12-011212302010.3390/diagnostics12123020Duration of Diabetes as a Risk Factor for Retinal Microvasculature Alterations Detected with Optical Coherence Tomography Angiography in Patients without Clinical RetinopathyJing Qian0Zeeshan Haq1Daphne Yang2Joy Q. Jin3Jay M. Stewart4Department of Ophthalmology, University of California, San Francisco, CA 94158, USADepartment of Ophthalmology, University of California, San Francisco, CA 94158, USADepartment of Ophthalmology, University of California, San Francisco, CA 94158, USADepartment of Ophthalmology, University of California, San Francisco, CA 94158, USADepartment of Ophthalmology, University of California, San Francisco, CA 94158, USAIn this study, we examined the impact of diabetes mellitus (DM) disease duration on optical coherence tomography angiography (OCTA) parameters in diabetic patients without diabetic retinopathy (DR). A total of 1118 eyes from 1118 DM patients without DR were divided into three groups by DM duration: 0–5 years (short cohort; <i>n</i> = 571), 6–10 years (medium cohort; <i>n</i> = 306), and >10 years (long cohort; <i>n</i> = 241). Ultra-widefield fundus photography and nine OCTA parameters derived from the superficial retinal capillary plexus were analyzed. Perfusion density (PD) and vessel length density (VD) were significantly decreased within the 1 mm patch in patient OCTAs from the medium cohort compared to the short cohort. Conversely, PD and VD were significantly decreased within the 6 mm patch and inner ring among the long cohort compared to the short and medium cohorts. These findings remained consistent after controlled analysis. Patients in the medium cohort had the largest FAZ area, while patients in the long cohort had the smallest FAZ area, with a statistically significant difference between the two groups. Superficial PD and VD significantly decreased among the medium and long cohorts compared to the short cohort, confirming that subclinical, progressive macular vasculature change is associated with longer DM duration. However, while FAZ area significantly increased in the medium cohort, the long cohort exhibited decreased FAZ area, suggesting the latter may possess protective factors that decrease overall risk of DR development.https://www.mdpi.com/2075-4418/12/12/3020optical coherence tomography angiographydiabetesfoveal avascular zonesuperficial capillary plexusvessel density |
| spellingShingle | Jing Qian Zeeshan Haq Daphne Yang Joy Q. Jin Jay M. Stewart Duration of Diabetes as a Risk Factor for Retinal Microvasculature Alterations Detected with Optical Coherence Tomography Angiography in Patients without Clinical Retinopathy Diagnostics optical coherence tomography angiography diabetes foveal avascular zone superficial capillary plexus vessel density |
| title | Duration of Diabetes as a Risk Factor for Retinal Microvasculature Alterations Detected with Optical Coherence Tomography Angiography in Patients without Clinical Retinopathy |
| title_full | Duration of Diabetes as a Risk Factor for Retinal Microvasculature Alterations Detected with Optical Coherence Tomography Angiography in Patients without Clinical Retinopathy |
| title_fullStr | Duration of Diabetes as a Risk Factor for Retinal Microvasculature Alterations Detected with Optical Coherence Tomography Angiography in Patients without Clinical Retinopathy |
| title_full_unstemmed | Duration of Diabetes as a Risk Factor for Retinal Microvasculature Alterations Detected with Optical Coherence Tomography Angiography in Patients without Clinical Retinopathy |
| title_short | Duration of Diabetes as a Risk Factor for Retinal Microvasculature Alterations Detected with Optical Coherence Tomography Angiography in Patients without Clinical Retinopathy |
| title_sort | duration of diabetes as a risk factor for retinal microvasculature alterations detected with optical coherence tomography angiography in patients without clinical retinopathy |
| topic | optical coherence tomography angiography diabetes foveal avascular zone superficial capillary plexus vessel density |
| url | https://www.mdpi.com/2075-4418/12/12/3020 |
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