The association of exaggerated hypertensive response to exercise and beta-blockers use in hypertensives
Purpose An elevation in blood pressure (BP) during exercise is the normal physiological response, however an abnormally exaggerated rise in BP, in terms of hypertensive response to exercise (HRE), is seen as a prognostic factor for end-organ damage and mortality. HRE is more common in hypertensive (...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-11-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2020.1779284 |
| _version_ | 1797681319116800000 |
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| author | Kadir Uğur Mert Emre Şener Ahmet Serdar Yılmaz Gurbet Özge Mert Furkan Yetmiş Muhammet Dural Erdi Babayigit Selda Murat Yuksel Cavusoglu Taner Ulus Bülent Görenek |
| author_facet | Kadir Uğur Mert Emre Şener Ahmet Serdar Yılmaz Gurbet Özge Mert Furkan Yetmiş Muhammet Dural Erdi Babayigit Selda Murat Yuksel Cavusoglu Taner Ulus Bülent Görenek |
| author_sort | Kadir Uğur Mert |
| collection | DOAJ |
| description | Purpose An elevation in blood pressure (BP) during exercise is the normal physiological response, however an abnormally exaggerated rise in BP, in terms of hypertensive response to exercise (HRE), is seen as a prognostic factor for end-organ damage and mortality. HRE is more common in hypertensive (HT) patients and data are lacking on the effect of antihypertensive medication on HRE. In this study, we evaluated patients who underwent treadmill exercise testing (TET) to reveal the effect of antihypertensive medication on HRE. Materials and Methods A cohort of 2970 individuals underwent TET and data were evaluated for HRE development. HRE has been defined as a systolic BP>210 mmHg in males and >190 mmHg in females throughout the TET. To reveal the effects of antihypertensive medication on HRE, 992 HT patients were analyzed. Results HRE was observed in 11.4% (n = 113) of HT patients and 5.9% (n = 107) of non-HT individuals(p < .001). HRE was observed significantly more in males (57.6% vs. 67.3%;p = .033), and in patients with higher body mass index BMI (29.1 ± 4.5 vs. 30.3 ± 5.2;0.033). There was no significant association between medication and HRE development apart from beta-blockers. Also, gender (odds ratio:1.787; 95%CI:1.160–2.751;p = .008), BMI (odds ratio:1.070;95%CI:1.025–1.116;p = .002) and being under beta-blocker treatment (odds ratio:0.637;95%CI:0.428–0.949;p = .026) were found to be independent predictors of HRE in multivariate logistic regression analysis. Conclusion HRE was associated with gender, BMI and beta-blocker use in hypertensive with male gender and higher BMI associated with higher HRE, while beta-blocker-based treatment, either mono- or combination therapy, associated with lower HRE. |
| first_indexed | 2024-03-11T23:43:13Z |
| format | Article |
| id | doaj.art-b1dc120213b34025b96bc6833a20ec98 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:43:13Z |
| publishDate | 2020-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-b1dc120213b34025b96bc6833a20ec982023-09-19T15:19:29ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062020-11-0142870771310.1080/10641963.2020.17792841779284The association of exaggerated hypertensive response to exercise and beta-blockers use in hypertensivesKadir Uğur Mert0Emre Şener1Ahmet Serdar Yılmaz2Gurbet Özge Mert3Furkan Yetmiş4Muhammet Dural5Erdi Babayigit6Selda Murat7Yuksel Cavusoglu8Taner Ulus9Bülent Görenek10Eskişehir Osmangazi UniversityEskişehir Osmangazi UniversityEskişehir Osmangazi UniversityEskisehir Yunus Emre, State HospitalEskişehir Osmangazi UniversityEskişehir Osmangazi UniversityKulu State HospitalEskişehir Osmangazi UniversityEskişehir Osmangazi UniversityEskişehir Osmangazi UniversityEskişehir Osmangazi UniversityPurpose An elevation in blood pressure (BP) during exercise is the normal physiological response, however an abnormally exaggerated rise in BP, in terms of hypertensive response to exercise (HRE), is seen as a prognostic factor for end-organ damage and mortality. HRE is more common in hypertensive (HT) patients and data are lacking on the effect of antihypertensive medication on HRE. In this study, we evaluated patients who underwent treadmill exercise testing (TET) to reveal the effect of antihypertensive medication on HRE. Materials and Methods A cohort of 2970 individuals underwent TET and data were evaluated for HRE development. HRE has been defined as a systolic BP>210 mmHg in males and >190 mmHg in females throughout the TET. To reveal the effects of antihypertensive medication on HRE, 992 HT patients were analyzed. Results HRE was observed in 11.4% (n = 113) of HT patients and 5.9% (n = 107) of non-HT individuals(p < .001). HRE was observed significantly more in males (57.6% vs. 67.3%;p = .033), and in patients with higher body mass index BMI (29.1 ± 4.5 vs. 30.3 ± 5.2;0.033). There was no significant association between medication and HRE development apart from beta-blockers. Also, gender (odds ratio:1.787; 95%CI:1.160–2.751;p = .008), BMI (odds ratio:1.070;95%CI:1.025–1.116;p = .002) and being under beta-blocker treatment (odds ratio:0.637;95%CI:0.428–0.949;p = .026) were found to be independent predictors of HRE in multivariate logistic regression analysis. Conclusion HRE was associated with gender, BMI and beta-blocker use in hypertensive with male gender and higher BMI associated with higher HRE, while beta-blocker-based treatment, either mono- or combination therapy, associated with lower HRE.http://dx.doi.org/10.1080/10641963.2020.1779284hypertensionbeta blockeranti-hypertensiveexaggerated blood pressurehypertensive response to exercise |
| spellingShingle | Kadir Uğur Mert Emre Şener Ahmet Serdar Yılmaz Gurbet Özge Mert Furkan Yetmiş Muhammet Dural Erdi Babayigit Selda Murat Yuksel Cavusoglu Taner Ulus Bülent Görenek The association of exaggerated hypertensive response to exercise and beta-blockers use in hypertensives Clinical and Experimental Hypertension hypertension beta blocker anti-hypertensive exaggerated blood pressure hypertensive response to exercise |
| title | The association of exaggerated hypertensive response to exercise and beta-blockers use in hypertensives |
| title_full | The association of exaggerated hypertensive response to exercise and beta-blockers use in hypertensives |
| title_fullStr | The association of exaggerated hypertensive response to exercise and beta-blockers use in hypertensives |
| title_full_unstemmed | The association of exaggerated hypertensive response to exercise and beta-blockers use in hypertensives |
| title_short | The association of exaggerated hypertensive response to exercise and beta-blockers use in hypertensives |
| title_sort | association of exaggerated hypertensive response to exercise and beta blockers use in hypertensives |
| topic | hypertension beta blocker anti-hypertensive exaggerated blood pressure hypertensive response to exercise |
| url | http://dx.doi.org/10.1080/10641963.2020.1779284 |
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