lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via <i>trans</i>-Regulatory Actions
Hair follicles (HFs) are complex organs that grow cyclically during mammals’ growth and development. Long non-coding RNAs (lncRNAs) cannot be translated into proteins and play crucial roles in many biological processes. In our previous study, candidate lncRNAs associated with HF cyclic regeneration...
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MDPI AG
2022-08-01
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| author | Bohao Zhao Jiali Li Ming Liu Shuaishuai Hu Naisu Yang Shuang Liang Xiyu Zhang Yingying Dai Zhiyuan Bao Yang Chen Xinsheng Wu |
| author_facet | Bohao Zhao Jiali Li Ming Liu Shuaishuai Hu Naisu Yang Shuang Liang Xiyu Zhang Yingying Dai Zhiyuan Bao Yang Chen Xinsheng Wu |
| author_sort | Bohao Zhao |
| collection | DOAJ |
| description | Hair follicles (HFs) are complex organs that grow cyclically during mammals’ growth and development. Long non-coding RNAs (lncRNAs) cannot be translated into proteins and play crucial roles in many biological processes. In our previous study, candidate lncRNAs associated with HF cyclic regeneration were screened, and we identified that the novel lncRNA, lncRNA2919, was significantly expressed during catagen. Here, we identified that lncRNA2919 has no coding potentiality and is highly expressed in the cell nucleus, and downregulates HF growth and development-related genes, inhibits cell proliferation, and promotes cell apoptosis in rabbit dermal papilla cells. lncRNA2919 recruits STAT1 to form a compound. As a key transcription factor, STAT1 regulates the transcriptional expression of KRTAP11-1. Our study revealed that lncRNA2919 is involved in HF cyclic regeneration through the <i>trans</i>-regulatory lncRNA2919–STAT1–KRTAP11-1 axis. This study elucidates the mechanism through which lncRNA2919 regulates HF growth and development and the role of lncRNA2919 as a new therapeutic target in animal wool production and human hair-related disease treatment. |
| first_indexed | 2024-03-09T10:09:47Z |
| format | Article |
| id | doaj.art-b1dcf8e24a7647fbaa70a5d61b4bea7b |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T10:09:47Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
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| spelling | doaj.art-b1dcf8e24a7647fbaa70a5d61b4bea7b2023-12-01T22:53:17ZengMDPI AGCells2073-44092022-08-011115244310.3390/cells11152443lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via <i>trans</i>-Regulatory ActionsBohao Zhao0Jiali Li1Ming Liu2Shuaishuai Hu3Naisu Yang4Shuang Liang5Xiyu Zhang6Yingying Dai7Zhiyuan Bao8Yang Chen9Xinsheng Wu10College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou 225009, ChinaHair follicles (HFs) are complex organs that grow cyclically during mammals’ growth and development. Long non-coding RNAs (lncRNAs) cannot be translated into proteins and play crucial roles in many biological processes. In our previous study, candidate lncRNAs associated with HF cyclic regeneration were screened, and we identified that the novel lncRNA, lncRNA2919, was significantly expressed during catagen. Here, we identified that lncRNA2919 has no coding potentiality and is highly expressed in the cell nucleus, and downregulates HF growth and development-related genes, inhibits cell proliferation, and promotes cell apoptosis in rabbit dermal papilla cells. lncRNA2919 recruits STAT1 to form a compound. As a key transcription factor, STAT1 regulates the transcriptional expression of KRTAP11-1. Our study revealed that lncRNA2919 is involved in HF cyclic regeneration through the <i>trans</i>-regulatory lncRNA2919–STAT1–KRTAP11-1 axis. This study elucidates the mechanism through which lncRNA2919 regulates HF growth and development and the role of lncRNA2919 as a new therapeutic target in animal wool production and human hair-related disease treatment.https://www.mdpi.com/2073-4409/11/15/2443lncRNA2919hair follicle growth and developmentdermal papilla cells<i>trans</i> regulationKRTAP11-1STAT1 |
| spellingShingle | Bohao Zhao Jiali Li Ming Liu Shuaishuai Hu Naisu Yang Shuang Liang Xiyu Zhang Yingying Dai Zhiyuan Bao Yang Chen Xinsheng Wu lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via <i>trans</i>-Regulatory Actions Cells lncRNA2919 hair follicle growth and development dermal papilla cells <i>trans</i> regulation KRTAP11-1 STAT1 |
| title | lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via <i>trans</i>-Regulatory Actions |
| title_full | lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via <i>trans</i>-Regulatory Actions |
| title_fullStr | lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via <i>trans</i>-Regulatory Actions |
| title_full_unstemmed | lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via <i>trans</i>-Regulatory Actions |
| title_short | lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via <i>trans</i>-Regulatory Actions |
| title_sort | lncrna2919 suppresses rabbit dermal papilla cell proliferation via i trans i regulatory actions |
| topic | lncRNA2919 hair follicle growth and development dermal papilla cells <i>trans</i> regulation KRTAP11-1 STAT1 |
| url | https://www.mdpi.com/2073-4409/11/15/2443 |
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