Metabolic radiolabeling and in vivo PET imaging of cytotoxic T lymphocytes to guide combination adoptive cell transfer cancer therapy

Metabolic radiolabeling and in vivo PET imaging of cytotoxic T lymphocytes to guide combination adoptive cell transfer cancer therapy

Abstract Background Adoptive T cell transfer-based immunotherapy yields unsatisfactory results in the treatment of solid tumors, partially owing to limited tumor infiltration and the immunosuppressive microenvironment in solid tumors. Therefore, strategies for the noninvasive tracking of adoptive T...

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Bibliographic Details
Main Authors: Dehua Lu, Yanpu Wang, Ting Zhang, Feng Wang, Kui Li, Shixin Zhou, Hua Zhu, Zhi Yang, Zhaofei Liu
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Nanobiotechnology
Subjects:
Positron emission tomography
Radiolabeling
Adoptive cell transfer
Focal adhesion kinase inhibition
Image-guided therapy
Online Access:https://doi.org/10.1186/s12951-021-00924-2

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