Maternal Vitamin D Deficiency and the Risk of Small for Gestational Age: A Meta-analysis
Background: Inconsistencies among studies still exist in regard to the associations between maternal vitamin D deficiency and the risk of small for gestational age. Methods: We conducted a meta-analysis of observational studies to evaluate these associations. We searched electronic databases for...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2018-12-01
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| Series: | Iranian Journal of Public Health |
| Subjects: | |
| Online Access: | https://ijph.tums.ac.ir/index.php/ijph/article/view/15503 |
| _version_ | 1831645398020653056 |
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| author | Zhao HU Lu TANG Hui-Lan XU |
| author_facet | Zhao HU Lu TANG Hui-Lan XU |
| author_sort | Zhao HU |
| collection | DOAJ |
| description | Background: Inconsistencies among studies still exist in regard to the associations between maternal vitamin D deficiency and the risk of small for gestational age.
Methods: We conducted a meta-analysis of observational studies to evaluate these associations. We searched electronic databases for literature published in PubMed, Medline, Web of Science, Embase and the Cochrane Library up to Dec 2016 using the following keywords: “vitamin D” or “cholecalciferol” or “25-OHD” or “25-hydroxyvitamin D” in combination with “small for gestational age” or “SGA” or “fetal outcome” or “pregnancy outcome”.
Results: Twelve studies involving 19,027 participants were included in this meta-analysis. Pregnant women with vitamin D deficiency (25-OHD levels<50 nmol/L) experienced an increased risk of SGA (odds ratio (OR) =1.41, 95% confidence interval (CI): 1.14, 1.75). The vitamin D concentration of the SGA group was lower than that of the non-SGA group (mean difference: -1.75 nmol/L, 95%CI:-3.23, -0.27).
Conclusion: Maternal vitamin D deficiency during pregnancy may be associated with an increased risk of SGA. |
| first_indexed | 2024-12-19T13:35:58Z |
| format | Article |
| id | doaj.art-b1de9f87fa0649efa76d090e93dea620 |
| institution | Directory Open Access Journal |
| issn | 2251-6085 2251-6093 |
| language | English |
| last_indexed | 2024-12-19T13:35:58Z |
| publishDate | 2018-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Public Health |
| spelling | doaj.art-b1de9f87fa0649efa76d090e93dea6202022-12-21T20:19:13ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932018-12-014712Maternal Vitamin D Deficiency and the Risk of Small for Gestational Age: A Meta-analysisZhao HU0Lu TANG1Hui-Lan XU2Dept. of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha 410078, ChinaDept. of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha 410078, ChinaDept. of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha 410078, ChinaBackground: Inconsistencies among studies still exist in regard to the associations between maternal vitamin D deficiency and the risk of small for gestational age. Methods: We conducted a meta-analysis of observational studies to evaluate these associations. We searched electronic databases for literature published in PubMed, Medline, Web of Science, Embase and the Cochrane Library up to Dec 2016 using the following keywords: “vitamin D” or “cholecalciferol” or “25-OHD” or “25-hydroxyvitamin D” in combination with “small for gestational age” or “SGA” or “fetal outcome” or “pregnancy outcome”. Results: Twelve studies involving 19,027 participants were included in this meta-analysis. Pregnant women with vitamin D deficiency (25-OHD levels<50 nmol/L) experienced an increased risk of SGA (odds ratio (OR) =1.41, 95% confidence interval (CI): 1.14, 1.75). The vitamin D concentration of the SGA group was lower than that of the non-SGA group (mean difference: -1.75 nmol/L, 95%CI:-3.23, -0.27). Conclusion: Maternal vitamin D deficiency during pregnancy may be associated with an increased risk of SGA.https://ijph.tums.ac.ir/index.php/ijph/article/view/15503Vitamin DSmall for gestational agePregnancy |
| spellingShingle | Zhao HU Lu TANG Hui-Lan XU Maternal Vitamin D Deficiency and the Risk of Small for Gestational Age: A Meta-analysis Iranian Journal of Public Health Vitamin D Small for gestational age Pregnancy |
| title | Maternal Vitamin D Deficiency and the Risk of Small for Gestational Age: A Meta-analysis |
| title_full | Maternal Vitamin D Deficiency and the Risk of Small for Gestational Age: A Meta-analysis |
| title_fullStr | Maternal Vitamin D Deficiency and the Risk of Small for Gestational Age: A Meta-analysis |
| title_full_unstemmed | Maternal Vitamin D Deficiency and the Risk of Small for Gestational Age: A Meta-analysis |
| title_short | Maternal Vitamin D Deficiency and the Risk of Small for Gestational Age: A Meta-analysis |
| title_sort | maternal vitamin d deficiency and the risk of small for gestational age a meta analysis |
| topic | Vitamin D Small for gestational age Pregnancy |
| url | https://ijph.tums.ac.ir/index.php/ijph/article/view/15503 |
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