Severity of Fatigue and Its Relationship with TSH before and after Levothyroxine Replacement Therapy in Patients with Primary Hypothyroidism
Background: Fatigue is a common symptom in hypothyroidism; however, the effect of levothyroxine on fatigue has been little studied. The aim of this study was to evaluate the effect of levothyroxine on fatigue in Latino patients with primary hypothyroidism, as well as the association of TSH and free...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/3/811 |
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| author | María Guadalupe Ruíz-Pacheco Irma Hernández Guadalupe Hernández-Estrella Lourdes Basurto Guadalupe Vargas-Ortega Baldomero González-Virla Mario Molina-Ayala Alex Francisco Hernández-Martínez Rosamaría Luengas-Mondragón Angel Alejandro Hernández-Allende Victoria Mendoza-Zubieta Lourdes Balcázar-Hernández |
| author_facet | María Guadalupe Ruíz-Pacheco Irma Hernández Guadalupe Hernández-Estrella Lourdes Basurto Guadalupe Vargas-Ortega Baldomero González-Virla Mario Molina-Ayala Alex Francisco Hernández-Martínez Rosamaría Luengas-Mondragón Angel Alejandro Hernández-Allende Victoria Mendoza-Zubieta Lourdes Balcázar-Hernández |
| author_sort | María Guadalupe Ruíz-Pacheco |
| collection | DOAJ |
| description | Background: Fatigue is a common symptom in hypothyroidism; however, the effect of levothyroxine on fatigue has been little studied. The aim of this study was to evaluate the effect of levothyroxine on fatigue in Latino patients with primary hypothyroidism, as well as the association of TSH and free T4 (FT4) with the severity and persistence of fatigue. Methods: A prospective study was performed in 92 patients with primary hypothyroidism. Fatigue severity scale (FSS) scores and clinical and biochemical characteristics before and at 6 months of levothyroxine were evaluated. Results: After 6 months of levothyroxine, a reduction in FSS (53 (47–57) vs. 36 (16–38); <i>p</i> = 0.001) and fatigue frequency (45.7% vs. 26.1%; <i>p</i> = 0.008) was evident. Both before and after 6 months of levothyroxine, there was a positive correlation of the FSS score with TSH and a negative correlation with FT4. Persistent fatigue was associated with a pretreatment FSS score (r = 0.75; <i>p</i> = 0.001) and diabetes (r = 0.40; <i>p</i> = 0.001). An FSS > 34 (RR 3.9 (95% CI 1.43–10.73; <i>p</i> = 0.008)), an FSS > 36 (RR 3.23 (95% CI 1.21–8.6; <i>p</i> = 0.019)), and diabetes (RR 5.7 (95% CI 1.25–9.6; <i>p</i> = 0.024)) before treatment were risk factors for persistent fatigue. Conclusions: Levothyroxine improved fatigue in most patients. Diabetes and an FSS score >34 or >36 before treatment were risk factors for persistent fatigue. |
| first_indexed | 2024-03-11T06:53:48Z |
| format | Article |
| id | doaj.art-b1e349b11fd8476d85835b7b29526ae7 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T06:53:48Z |
| publishDate | 2023-03-01 |
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| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-b1e349b11fd8476d85835b7b29526ae72023-11-17T09:45:55ZengMDPI AGBiomedicines2227-90592023-03-0111381110.3390/biomedicines11030811Severity of Fatigue and Its Relationship with TSH before and after Levothyroxine Replacement Therapy in Patients with Primary HypothyroidismMaría Guadalupe Ruíz-Pacheco0Irma Hernández1Guadalupe Hernández-Estrella2Lourdes Basurto3Guadalupe Vargas-Ortega4Baldomero González-Virla5Mario Molina-Ayala6Alex Francisco Hernández-Martínez7Rosamaría Luengas-Mondragón8Angel Alejandro Hernández-Allende9Victoria Mendoza-Zubieta10Lourdes Balcázar-Hernández11Centro Médico Nacional Siglo XXI, Department of Endocrinology, Hospital de Especialidades, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoCentro Médico Nacional Siglo XXI, Department of Endocrinology, Hospital de Especialidades, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoUnidad de Medicina Familiar No. 69, Department of Family Medicine, Instituto Mexicano del Seguro Social, Calle José María Morelos 210-232, Centro, Texcoco 56100, MexicoEndocrine Diseases Research Unit, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoCentro Médico Nacional Siglo XXI, Department of Endocrinology, Hospital de Especialidades, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoCentro Médico Nacional Siglo XXI, Department of Endocrinology, Hospital de Especialidades, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoCentro Médico Nacional Siglo XXI, Department of Endocrinology, Hospital de Especialidades, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoCentro Médico Nacional Siglo XXI, Department of Endocrinology, Hospital de Especialidades, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoFaculty of Medicine, Universidad Nacional Autónoma de México, Mexico City 04510, MexicoFaculty of Medicine, Universidad Nacional Autónoma de México, Mexico City 04510, MexicoCentro Médico Nacional Siglo XXI, Department of Endocrinology, Hospital de Especialidades, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoCentro Médico Nacional Siglo XXI, Department of Endocrinology, Hospital de Especialidades, Instituto Mexicano del Seguro Social, Mexico City 06720, MexicoBackground: Fatigue is a common symptom in hypothyroidism; however, the effect of levothyroxine on fatigue has been little studied. The aim of this study was to evaluate the effect of levothyroxine on fatigue in Latino patients with primary hypothyroidism, as well as the association of TSH and free T4 (FT4) with the severity and persistence of fatigue. Methods: A prospective study was performed in 92 patients with primary hypothyroidism. Fatigue severity scale (FSS) scores and clinical and biochemical characteristics before and at 6 months of levothyroxine were evaluated. Results: After 6 months of levothyroxine, a reduction in FSS (53 (47–57) vs. 36 (16–38); <i>p</i> = 0.001) and fatigue frequency (45.7% vs. 26.1%; <i>p</i> = 0.008) was evident. Both before and after 6 months of levothyroxine, there was a positive correlation of the FSS score with TSH and a negative correlation with FT4. Persistent fatigue was associated with a pretreatment FSS score (r = 0.75; <i>p</i> = 0.001) and diabetes (r = 0.40; <i>p</i> = 0.001). An FSS > 34 (RR 3.9 (95% CI 1.43–10.73; <i>p</i> = 0.008)), an FSS > 36 (RR 3.23 (95% CI 1.21–8.6; <i>p</i> = 0.019)), and diabetes (RR 5.7 (95% CI 1.25–9.6; <i>p</i> = 0.024)) before treatment were risk factors for persistent fatigue. Conclusions: Levothyroxine improved fatigue in most patients. Diabetes and an FSS score >34 or >36 before treatment were risk factors for persistent fatigue.https://www.mdpi.com/2227-9059/11/3/811fatiguehypothyroidismthyrotropinlevothyroxine |
| spellingShingle | María Guadalupe Ruíz-Pacheco Irma Hernández Guadalupe Hernández-Estrella Lourdes Basurto Guadalupe Vargas-Ortega Baldomero González-Virla Mario Molina-Ayala Alex Francisco Hernández-Martínez Rosamaría Luengas-Mondragón Angel Alejandro Hernández-Allende Victoria Mendoza-Zubieta Lourdes Balcázar-Hernández Severity of Fatigue and Its Relationship with TSH before and after Levothyroxine Replacement Therapy in Patients with Primary Hypothyroidism Biomedicines fatigue hypothyroidism thyrotropin levothyroxine |
| title | Severity of Fatigue and Its Relationship with TSH before and after Levothyroxine Replacement Therapy in Patients with Primary Hypothyroidism |
| title_full | Severity of Fatigue and Its Relationship with TSH before and after Levothyroxine Replacement Therapy in Patients with Primary Hypothyroidism |
| title_fullStr | Severity of Fatigue and Its Relationship with TSH before and after Levothyroxine Replacement Therapy in Patients with Primary Hypothyroidism |
| title_full_unstemmed | Severity of Fatigue and Its Relationship with TSH before and after Levothyroxine Replacement Therapy in Patients with Primary Hypothyroidism |
| title_short | Severity of Fatigue and Its Relationship with TSH before and after Levothyroxine Replacement Therapy in Patients with Primary Hypothyroidism |
| title_sort | severity of fatigue and its relationship with tsh before and after levothyroxine replacement therapy in patients with primary hypothyroidism |
| topic | fatigue hypothyroidism thyrotropin levothyroxine |
| url | https://www.mdpi.com/2227-9059/11/3/811 |
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