FREQUENCY AND RISK FACTORS OF MULTI-DRUG RESISTANT TUBERCULOSIS IN KHYBER PAKHTUNKHWA, PAKISTAN: A RETROSPECTIVE STUDY
Introduction: Multi-drug resistant TB (MDR-TB) is a major health problem worldwide especially in Pakistan. It infects around 7000 individuals annually. Many factors are related to the disease prevalence and disease transmission, however, limited data is available in Khyber Pakhtunkhwa (KP). We desig...
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| Format: | Article |
| Language: | English |
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Rehman Medical Institute
2021-12-01
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| Series: | Rehman Journal of Health Sciences |
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| Online Access: | http://www.rjhs.pk/index.php/rehman-journal-of-health-science/article/view/97 |
| _version_ | 1797783325329326080 |
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| author | Anita Mughul Mizna Arif Furqan Ali Shah Sikandar Ali Khan Sommaira Jabeen Shah Karishma Ali Shah Fahad Ali Khan Zia Ullah Shah Irfan Ullah |
| author_facet | Anita Mughul Mizna Arif Furqan Ali Shah Sikandar Ali Khan Sommaira Jabeen Shah Karishma Ali Shah Fahad Ali Khan Zia Ullah Shah Irfan Ullah |
| author_sort | Anita Mughul |
| collection | DOAJ |
| description | Introduction: Multi-drug resistant TB (MDR-TB) is a major health problem worldwide especially in Pakistan. It infects around 7000 individuals annually. Many factors are related to the disease prevalence and disease transmission, however, limited data is available in Khyber Pakhtunkhwa (KP). We designed a study that provides an opportunity to mark the rich pockets and the predictors of the implications of MDR-TB in KP.
Material & Methods: A cross-sectional study was conducted for a period of 1-year (2016-2017) at the unit of Programmatic Management of Drug-resistant TB (PMDT) located in tertiary care hospital, Lady Reading Hospital (LRH).
Results: Out of 1015 cases, 137 (14%) were detected rifampicin-resistant (RR) by Xpert MTB/RIF. Mutation present in codon 531 of the rpoBgene was observed frequently. Females 529 (52%) with the dominant age range of (<44 years) were found more compared to males. Participants residing in rural areas have 5% lower chances of MDR-TB than urban ones. The rural (54%) participants using biomass were significantly associated with the disease. Diabetes prevalence was found in 22%, and the most obvious clinical manifestation was productive cough 95% of MDR-TB but the test was statistically insignificant.
Conclusion: The increase in patients of MDR-TB amongst prior exposure to anti-TB medications is an issue of incredible concern. MDR-TB issue is noticeable in rural inhabitants of KP. A major gap was found about the awareness of respondents cross-examined in regards to the study of disease transmission, risk factors, signs and side effects, and proper anticipation strategies. Xpert MTB/RIF is the best option in high settings due to the short turnout time. |
| first_indexed | 2024-03-13T00:24:26Z |
| format | Article |
| id | doaj.art-b1e496609f3f4f3fb92d33703fd75dbd |
| institution | Directory Open Access Journal |
| issn | 2664-4630 2708-2512 |
| language | English |
| last_indexed | 2024-03-13T00:24:26Z |
| publishDate | 2021-12-01 |
| publisher | Rehman Medical Institute |
| record_format | Article |
| series | Rehman Journal of Health Sciences |
| spelling | doaj.art-b1e496609f3f4f3fb92d33703fd75dbd2023-07-11T08:07:39ZengRehman Medical InstituteRehman Journal of Health Sciences2664-46302708-25122021-12-0132110117https://doi.org/10.52442/rjhs.v3i2.97FREQUENCY AND RISK FACTORS OF MULTI-DRUG RESISTANT TUBERCULOSIS IN KHYBER PAKHTUNKHWA, PAKISTAN: A RETROSPECTIVE STUDYAnita Mughul0Mizna Arif1Furqan Ali Shah2Sikandar Ali Khan3Sommaira Jabeen Shah4Karishma Ali5Shah Fahad Ali Khan6Zia Ullah Shah7Irfan Ullah8Institute of Biological sciences, Sarhad university of Science and Information Technology, PakistanAmeerudin Medical College, LahoreDepartment of Pharmacology, Pakistan International Medical College, Peshawar, Khyber PakhtunkhwaDepartment of Haematology, Khyber Medical University, PeshawarDepartment of Biochemistry, Khyber Medical University, PeshawarDepartment of Oral Pathology, Peshawar Medical and Dental College, PeshawarDepartment of Zoology, University of ChitralSarhad university of Science and Information TechnologyDepartment of Allied Health Sciences, Iqra National University, Peshawar, Khyber Pakhtunkhwa, PakistanIntroduction: Multi-drug resistant TB (MDR-TB) is a major health problem worldwide especially in Pakistan. It infects around 7000 individuals annually. Many factors are related to the disease prevalence and disease transmission, however, limited data is available in Khyber Pakhtunkhwa (KP). We designed a study that provides an opportunity to mark the rich pockets and the predictors of the implications of MDR-TB in KP. Material & Methods: A cross-sectional study was conducted for a period of 1-year (2016-2017) at the unit of Programmatic Management of Drug-resistant TB (PMDT) located in tertiary care hospital, Lady Reading Hospital (LRH). Results: Out of 1015 cases, 137 (14%) were detected rifampicin-resistant (RR) by Xpert MTB/RIF. Mutation present in codon 531 of the rpoBgene was observed frequently. Females 529 (52%) with the dominant age range of (<44 years) were found more compared to males. Participants residing in rural areas have 5% lower chances of MDR-TB than urban ones. The rural (54%) participants using biomass were significantly associated with the disease. Diabetes prevalence was found in 22%, and the most obvious clinical manifestation was productive cough 95% of MDR-TB but the test was statistically insignificant. Conclusion: The increase in patients of MDR-TB amongst prior exposure to anti-TB medications is an issue of incredible concern. MDR-TB issue is noticeable in rural inhabitants of KP. A major gap was found about the awareness of respondents cross-examined in regards to the study of disease transmission, risk factors, signs and side effects, and proper anticipation strategies. Xpert MTB/RIF is the best option in high settings due to the short turnout time.http://www.rjhs.pk/index.php/rehman-journal-of-health-science/article/view/97multidrug-resistant tbrpob genexpert mtb/rif assay |
| spellingShingle | Anita Mughul Mizna Arif Furqan Ali Shah Sikandar Ali Khan Sommaira Jabeen Shah Karishma Ali Shah Fahad Ali Khan Zia Ullah Shah Irfan Ullah FREQUENCY AND RISK FACTORS OF MULTI-DRUG RESISTANT TUBERCULOSIS IN KHYBER PAKHTUNKHWA, PAKISTAN: A RETROSPECTIVE STUDY Rehman Journal of Health Sciences multidrug-resistant tb rpob gene xpert mtb/rif assay |
| title | FREQUENCY AND RISK FACTORS OF MULTI-DRUG RESISTANT TUBERCULOSIS IN KHYBER PAKHTUNKHWA, PAKISTAN: A RETROSPECTIVE STUDY |
| title_full | FREQUENCY AND RISK FACTORS OF MULTI-DRUG RESISTANT TUBERCULOSIS IN KHYBER PAKHTUNKHWA, PAKISTAN: A RETROSPECTIVE STUDY |
| title_fullStr | FREQUENCY AND RISK FACTORS OF MULTI-DRUG RESISTANT TUBERCULOSIS IN KHYBER PAKHTUNKHWA, PAKISTAN: A RETROSPECTIVE STUDY |
| title_full_unstemmed | FREQUENCY AND RISK FACTORS OF MULTI-DRUG RESISTANT TUBERCULOSIS IN KHYBER PAKHTUNKHWA, PAKISTAN: A RETROSPECTIVE STUDY |
| title_short | FREQUENCY AND RISK FACTORS OF MULTI-DRUG RESISTANT TUBERCULOSIS IN KHYBER PAKHTUNKHWA, PAKISTAN: A RETROSPECTIVE STUDY |
| title_sort | frequency and risk factors of multi drug resistant tuberculosis in khyber pakhtunkhwa pakistan a retrospective study |
| topic | multidrug-resistant tb rpob gene xpert mtb/rif assay |
| url | http://www.rjhs.pk/index.php/rehman-journal-of-health-science/article/view/97 |
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