Retroelement Insertion in a CRISPR/Cas9 Editing Site in the Early Embryo Intensifies Genetic Mosaicism

Retroelement Insertion in a CRISPR/Cas9 Editing Site in the Early Embryo Intensifies Genetic Mosaicism

Continued CRISPR/Cas9-mediated editing activity that allows differential and asynchronous modification of alleles in successive cell generations expands allelic complexity. To understand the earliest events during CRISPR/Cas9 editing and the allelic selection among the progeny of subsequent cell div...

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Bibliographic Details
Main Authors: Jeehyun Jeon, Jung Sun Park, Byungkuk Min, Sun-Ku Chung, Min Kyu Kim, Yong-Kook Kang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CRISPR
Cas9
embryo
mosaicism
sgRNA
embryonic stem cell
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00273/full

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