Embryo development is impaired by sperm mitochondrial-derived ROS
Abstract Background Basal energetic metabolism in sperm, particularly oxidative phosphorylation, is known to condition not only their oocyte fertilising ability, but also the subsequent embryo development. While the molecular pathways underlying these events still need to be elucidated, reactive oxy...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Biological Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40659-024-00483-4 |
| _version_ | 1797275871537528832 |
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| author | Yentel Mateo-Otero Marc Llavanera Marc Torres-Garrido Marc Yeste |
| author_facet | Yentel Mateo-Otero Marc Llavanera Marc Torres-Garrido Marc Yeste |
| author_sort | Yentel Mateo-Otero |
| collection | DOAJ |
| description | Abstract Background Basal energetic metabolism in sperm, particularly oxidative phosphorylation, is known to condition not only their oocyte fertilising ability, but also the subsequent embryo development. While the molecular pathways underlying these events still need to be elucidated, reactive oxygen species (ROS) could have a relevant role. We, therefore, aimed to describe the mechanisms through which mitochondrial activity can influence the first stages of embryo development. Results We first show that embryo development is tightly influenced by both intracellular ROS and mitochondrial activity. In addition, we depict that the inhibition of mitochondrial activity dramatically decreases intracellular ROS levels. Finally, we also demonstrate that the inhibition of mitochondrial respiration positively influences sperm DNA integrity, most likely because of the depletion of intracellular ROS formation. Conclusion Collectively, the data presented in this work reveals that impairment of early embryo development may result from the accumulation of sperm DNA damage caused by mitochondrial-derived ROS. |
| first_indexed | 2024-03-07T15:19:16Z |
| format | Article |
| id | doaj.art-b1e5e42629ff4354948249cf790f9ec0 |
| institution | Directory Open Access Journal |
| issn | 0717-6287 |
| language | English |
| last_indexed | 2024-03-07T15:19:16Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Biological Research |
| spelling | doaj.art-b1e5e42629ff4354948249cf790f9ec02024-03-05T17:44:32ZengBMCBiological Research0717-62872024-01-0157111110.1186/s40659-024-00483-4Embryo development is impaired by sperm mitochondrial-derived ROSYentel Mateo-Otero0Marc Llavanera1Marc Torres-Garrido2Marc Yeste3Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of GironaBiotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of GironaBiotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of GironaBiotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of GironaAbstract Background Basal energetic metabolism in sperm, particularly oxidative phosphorylation, is known to condition not only their oocyte fertilising ability, but also the subsequent embryo development. While the molecular pathways underlying these events still need to be elucidated, reactive oxygen species (ROS) could have a relevant role. We, therefore, aimed to describe the mechanisms through which mitochondrial activity can influence the first stages of embryo development. Results We first show that embryo development is tightly influenced by both intracellular ROS and mitochondrial activity. In addition, we depict that the inhibition of mitochondrial activity dramatically decreases intracellular ROS levels. Finally, we also demonstrate that the inhibition of mitochondrial respiration positively influences sperm DNA integrity, most likely because of the depletion of intracellular ROS formation. Conclusion Collectively, the data presented in this work reveals that impairment of early embryo development may result from the accumulation of sperm DNA damage caused by mitochondrial-derived ROS.https://doi.org/10.1186/s40659-024-00483-4Sperm metabolismMitochondrial respirationelectron transport chainCyanideOocyte fertilisationEmbryo development |
| spellingShingle | Yentel Mateo-Otero Marc Llavanera Marc Torres-Garrido Marc Yeste Embryo development is impaired by sperm mitochondrial-derived ROS Biological Research Sperm metabolism Mitochondrial respiration electron transport chain Cyanide Oocyte fertilisation Embryo development |
| title | Embryo development is impaired by sperm mitochondrial-derived ROS |
| title_full | Embryo development is impaired by sperm mitochondrial-derived ROS |
| title_fullStr | Embryo development is impaired by sperm mitochondrial-derived ROS |
| title_full_unstemmed | Embryo development is impaired by sperm mitochondrial-derived ROS |
| title_short | Embryo development is impaired by sperm mitochondrial-derived ROS |
| title_sort | embryo development is impaired by sperm mitochondrial derived ros |
| topic | Sperm metabolism Mitochondrial respiration electron transport chain Cyanide Oocyte fertilisation Embryo development |
| url | https://doi.org/10.1186/s40659-024-00483-4 |
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