Drosophila in the Heart of Understanding Cardiac Diseases: Modeling Channelopathies and Cardiomyopathies in the Fruitfly
Cardiovascular diseases and, among them, channelopathies and cardiomyopathies are a major cause of death worldwide. The molecular and genetic defects underlying these cardiac disorders are complex, leading to a large range of structural and functional heart phenotypes. Identification of molecular an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-02-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | http://www.mdpi.com/2308-3425/3/1/7 |
| _version_ | 1811233897408626688 |
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| author | Ouarda Taghli-Lamallem Emilie Plantié Krzysztof Jagla |
| author_facet | Ouarda Taghli-Lamallem Emilie Plantié Krzysztof Jagla |
| author_sort | Ouarda Taghli-Lamallem |
| collection | DOAJ |
| description | Cardiovascular diseases and, among them, channelopathies and cardiomyopathies are a major cause of death worldwide. The molecular and genetic defects underlying these cardiac disorders are complex, leading to a large range of structural and functional heart phenotypes. Identification of molecular and functional mechanisms disrupted by mutations causing channelopathies and cardiomyopathies is essential to understanding the link between an altered gene and clinical phenotype. The development of animal models has been proven to be efficient for functional studies in channelopathies and cardiomyopathies. In particular, the Drosophila model has been largely applied for deciphering the molecular and cellular pathways affected in these inherited cardiac disorders and for identifying their genetic modifiers. Here we review the utility and the main contributions of the fruitfly models for the better understanding of channelopathies and cardiomyopathies. We also discuss the investigated pathological mechanisms and the discoveries of evolutionarily conserved pathways which reinforce the value of Drosophila in modeling human cardiac diseases. |
| first_indexed | 2024-04-12T11:27:45Z |
| format | Article |
| id | doaj.art-b1e6a82d682b47b4a2a389605644d883 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-04-12T11:27:45Z |
| publishDate | 2016-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-b1e6a82d682b47b4a2a389605644d8832022-12-22T03:35:10ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252016-02-0131710.3390/jcdd3010007jcdd3010007Drosophila in the Heart of Understanding Cardiac Diseases: Modeling Channelopathies and Cardiomyopathies in the FruitflyOuarda Taghli-Lamallem0Emilie Plantié1Krzysztof Jagla2GReD (Genetics, Reproduction and Development laboratory), INSERM U1103, CNRS UMR6293, University of Clermont-Ferrand, 28 place Henri-Dunant, 63000 Clermont-Ferrand, FranceGReD (Genetics, Reproduction and Development laboratory), INSERM U1103, CNRS UMR6293, University of Clermont-Ferrand, 28 place Henri-Dunant, 63000 Clermont-Ferrand, FranceGReD (Genetics, Reproduction and Development laboratory), INSERM U1103, CNRS UMR6293, University of Clermont-Ferrand, 28 place Henri-Dunant, 63000 Clermont-Ferrand, FranceCardiovascular diseases and, among them, channelopathies and cardiomyopathies are a major cause of death worldwide. The molecular and genetic defects underlying these cardiac disorders are complex, leading to a large range of structural and functional heart phenotypes. Identification of molecular and functional mechanisms disrupted by mutations causing channelopathies and cardiomyopathies is essential to understanding the link between an altered gene and clinical phenotype. The development of animal models has been proven to be efficient for functional studies in channelopathies and cardiomyopathies. In particular, the Drosophila model has been largely applied for deciphering the molecular and cellular pathways affected in these inherited cardiac disorders and for identifying their genetic modifiers. Here we review the utility and the main contributions of the fruitfly models for the better understanding of channelopathies and cardiomyopathies. We also discuss the investigated pathological mechanisms and the discoveries of evolutionarily conserved pathways which reinforce the value of Drosophila in modeling human cardiac diseases.http://www.mdpi.com/2308-3425/3/1/7human cardiac diseaseDrosophilachannelopathiescardiomyopathiessarcomeric proteinscytoskeletal proteinsK+ channels |
| spellingShingle | Ouarda Taghli-Lamallem Emilie Plantié Krzysztof Jagla Drosophila in the Heart of Understanding Cardiac Diseases: Modeling Channelopathies and Cardiomyopathies in the Fruitfly Journal of Cardiovascular Development and Disease human cardiac disease Drosophila channelopathies cardiomyopathies sarcomeric proteins cytoskeletal proteins K+ channels |
| title | Drosophila in the Heart of Understanding Cardiac Diseases: Modeling Channelopathies and Cardiomyopathies in the Fruitfly |
| title_full | Drosophila in the Heart of Understanding Cardiac Diseases: Modeling Channelopathies and Cardiomyopathies in the Fruitfly |
| title_fullStr | Drosophila in the Heart of Understanding Cardiac Diseases: Modeling Channelopathies and Cardiomyopathies in the Fruitfly |
| title_full_unstemmed | Drosophila in the Heart of Understanding Cardiac Diseases: Modeling Channelopathies and Cardiomyopathies in the Fruitfly |
| title_short | Drosophila in the Heart of Understanding Cardiac Diseases: Modeling Channelopathies and Cardiomyopathies in the Fruitfly |
| title_sort | drosophila in the heart of understanding cardiac diseases modeling channelopathies and cardiomyopathies in the fruitfly |
| topic | human cardiac disease Drosophila channelopathies cardiomyopathies sarcomeric proteins cytoskeletal proteins K+ channels |
| url | http://www.mdpi.com/2308-3425/3/1/7 |
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