Indirect Spectrophotometric determination of paracetamol via oxidative coupling reaction using chlorocresol reagent
A spectrophotometric method is proposed for the determination of microgram amounts of paracetamol based on the reaction of hydrolytic product of paracetamol (p-aminophenol) with chlorochresol in the presence of dissolved atmospheric oxygen and sodium carbonate, The absorbance of the blue indophenol...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Arabic |
| Published: |
College of Education for Pure Sciences
2005-09-01
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| Series: | مجلة التربية والعلم |
| Subjects: | |
| Online Access: | https://edusj.mosuljournals.com/article_83054_51ff7178b2c51d605a5d01e95875d6df.pdf |
| _version_ | 1818272738721136640 |
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| author | Thabit S.Al-Ghabsha Theiaa N.Al-Sabha Mohammad S.Al-Enizzi |
| author_facet | Thabit S.Al-Ghabsha Theiaa N.Al-Sabha Mohammad S.Al-Enizzi |
| author_sort | Thabit S.Al-Ghabsha |
| collection | DOAJ |
| description | A spectrophotometric method is proposed for the determination of microgram amounts of paracetamol based on the reaction of hydrolytic product of paracetamol (p-aminophenol) with chlorochresol in the presence of dissolved atmospheric oxygen and sodium carbonate, The absorbance of the blue indophenol dye is measured at 630 nm and the molar absorptivity found to be 8,63xl03 l.mol"1 .cm"' and conforms to Beer's law obeyed over the range 0.1-8.0 Hg ml' .The method is successfully employed for assay of paracetamol in various pharmaceutical formulations and results have been compared well with those obtained by the official methods indicating that the proposed method can be applied successfully in the assay of pharmaceutical preparations for paracetamol. |
| first_indexed | 2024-12-12T21:46:51Z |
| format | Article |
| id | doaj.art-b1ea474bd5e048e0a38cb5775cb432ad |
| institution | Directory Open Access Journal |
| issn | 1812-125X 2664-2530 |
| language | Arabic |
| last_indexed | 2024-12-12T21:46:51Z |
| publishDate | 2005-09-01 |
| publisher | College of Education for Pure Sciences |
| record_format | Article |
| series | مجلة التربية والعلم |
| spelling | doaj.art-b1ea474bd5e048e0a38cb5775cb432ad2022-12-22T00:10:54ZaraCollege of Education for Pure Sciencesمجلة التربية والعلم1812-125X2664-25302005-09-0117411010.33899/edusj.2005.8305483054Indirect Spectrophotometric determination of paracetamol via oxidative coupling reaction using chlorocresol reagentThabit S.Al-GhabshaTheiaa N.Al-SabhaMohammad S.Al-EnizziA spectrophotometric method is proposed for the determination of microgram amounts of paracetamol based on the reaction of hydrolytic product of paracetamol (p-aminophenol) with chlorochresol in the presence of dissolved atmospheric oxygen and sodium carbonate, The absorbance of the blue indophenol dye is measured at 630 nm and the molar absorptivity found to be 8,63xl03 l.mol"1 .cm"' and conforms to Beer's law obeyed over the range 0.1-8.0 Hg ml' .The method is successfully employed for assay of paracetamol in various pharmaceutical formulations and results have been compared well with those obtained by the official methods indicating that the proposed method can be applied successfully in the assay of pharmaceutical preparations for paracetamol.https://edusj.mosuljournals.com/article_83054_51ff7178b2c51d605a5d01e95875d6df.pdfindirect spectrophotometricparacetamolchlorocresol reagent |
| spellingShingle | Thabit S.Al-Ghabsha Theiaa N.Al-Sabha Mohammad S.Al-Enizzi Indirect Spectrophotometric determination of paracetamol via oxidative coupling reaction using chlorocresol reagent مجلة التربية والعلم indirect spectrophotometric paracetamol chlorocresol reagent |
| title | Indirect Spectrophotometric determination of paracetamol via oxidative coupling reaction using chlorocresol reagent |
| title_full | Indirect Spectrophotometric determination of paracetamol via oxidative coupling reaction using chlorocresol reagent |
| title_fullStr | Indirect Spectrophotometric determination of paracetamol via oxidative coupling reaction using chlorocresol reagent |
| title_full_unstemmed | Indirect Spectrophotometric determination of paracetamol via oxidative coupling reaction using chlorocresol reagent |
| title_short | Indirect Spectrophotometric determination of paracetamol via oxidative coupling reaction using chlorocresol reagent |
| title_sort | indirect spectrophotometric determination of paracetamol via oxidative coupling reaction using chlorocresol reagent |
| topic | indirect spectrophotometric paracetamol chlorocresol reagent |
| url | https://edusj.mosuljournals.com/article_83054_51ff7178b2c51d605a5d01e95875d6df.pdf |
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