In vivo readout of CFTR function: ratiometric measurement of CFTR-dependent secretion by individual, identifiable human sweat glands.

In vivo readout of CFTR function: ratiometric measurement of CFTR-dependent secretion by individual, identifiable human sweat glands.

To assess CFTR function in vivo, we developed a bioassay that monitors and compares CFTR-dependent and CFTR-independent sweat secretion in parallel for multiple (~50) individual, identified glands in each subject. Sweating was stimulated by intradermally injected agonists and quantified by optically...

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Bibliographic Details
Main Authors: Jeffrey J Wine, Jessica E Char, Jonathan Chen, Hyung-Ju Cho, Colleen Dunn, Eric Frisbee, Nam Soo Joo, Carlos Milla, Sara E Modlin, Il-Ho Park, Ewart A C Thomas, Kim V Tran, Rohan Verma, Marlene H Wolfe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3811985?pdf=render

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