Aluminium chloride-induced hippocampal damage: CA3 hippocampal subfield involvement and the neuroprotective role of Buchholzia coriacea ethanolic seed extract
ABSTRACT: Background: Early signs of neurodegenerative events of Alzheimer's disease manifest within the hippocampus and presents as cognitive and memory impairment. Aluminium-chloride (AlCl3), a neurotoxicant interferes with the structure and functions of the hippocampus as well as its neurog...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Phytomedicine Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031321000865 |
| _version_ | 1829491406039678976 |
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| author | Stephen Taiye Adelodun Oluwadamilola Adunni Ishola Ayodeji Zabdiel Abijo Sunday Yinka Olatunji Joshua Oladele Owolabi John Afees Olanrewaju Damilare Adedayo Adekomi |
| author_facet | Stephen Taiye Adelodun Oluwadamilola Adunni Ishola Ayodeji Zabdiel Abijo Sunday Yinka Olatunji Joshua Oladele Owolabi John Afees Olanrewaju Damilare Adedayo Adekomi |
| author_sort | Stephen Taiye Adelodun |
| collection | DOAJ |
| description | ABSTRACT: Background: Early signs of neurodegenerative events of Alzheimer's disease manifest within the hippocampus and presents as cognitive and memory impairment. Aluminium-chloride (AlCl3), a neurotoxicant interferes with the structure and functions of the hippocampus as well as its neurogenesis, thereby causing cognitive and memory impairment. Buchholzia coriacea (BC), a plant of nutraceutical value is traditionally reputed to boost memory and cognitive functions. This study elucidated the neuroprotective role of Buchholzia coriacea seed extract on AlCl3-induced hippocampal neuronal damage in Wistar rat model by examining the biochemical, histological, immunohistochemical, and neurobehavioural changes. Methods: Twenty-five male Wistar rats were randomly assigned into five groups A-E (n = 5). Group A served as the control, groups B-E were given 200 mg/kg of AlCl3 for 14 days and then received 2 mLs/kg distilled water, 50mg/kg BC, 100mg/kg BC and 2.5mg/kg donepezil respectively for 14 days orally. Glutathione and neurotransmitters (Glutamate, dopamine, and acetylcholine) levels, G6PDH and neurobehavioral activities, as well as histological (H and E, LFB and Cresyl violet stains) and immunohistochemical (ionized calcium-binding adapter molecule 1, Iba-1) changes were evaluated Results: AlCl3 impaired spatial working memory with observable improvements in the treated groups. Enzymatic activity and neurotransmitter levels were augmented in the group treated with the highest dose of BC compared to the control. Histological assessment showed that BC high-dose mitigated neurodegenerative changes in the CA3 hippocampal subfield. Conclusion: Taken together, BC exhibited neuroprotective ability on AlCl3-induced CA3 hippocampal field neuronal damage and demonstrated memory impairment reversing ability. |
| first_indexed | 2024-12-15T00:37:08Z |
| format | Article |
| id | doaj.art-b1ee3631b1524066a21f121ba7f4d0fc |
| institution | Directory Open Access Journal |
| issn | 2667-0313 |
| language | English |
| last_indexed | 2024-12-15T00:37:08Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj.art-b1ee3631b1524066a21f121ba7f4d0fc2022-12-21T22:41:45ZengElsevierPhytomedicine Plus2667-03132021-11-0114100104Aluminium chloride-induced hippocampal damage: CA3 hippocampal subfield involvement and the neuroprotective role of Buchholzia coriacea ethanolic seed extractStephen Taiye Adelodun0Oluwadamilola Adunni Ishola1Ayodeji Zabdiel Abijo2Sunday Yinka Olatunji3Joshua Oladele Owolabi4John Afees Olanrewaju5Damilare Adedayo Adekomi6Department of Anatomy, Ben Carson School of Medicine, Babcock University, Ilishan-Remo, Ogun State, NigeriaDepartment of Anatomy, Ben Carson School of Medicine, Babcock University, Ilishan-Remo, Ogun State, NigeriaNeurobiology Unit, Department of Anatomy, Ladoke Akintola University of Technology Ogbomoso, Oyo State, Nigeria; Corresponding author.Department of Anatomy, Ben Carson School of Medicine, Babcock University, Ilishan-Remo, Ogun State, NigeriaDepartment of Anatomy, Ben Carson School of Medicine, Babcock University, Ilishan-Remo, Ogun State, NigeriaDepartment of Anatomy, Ben Carson School of Medicine, Babcock University, Ilishan-Remo, Ogun State, NigeriaDepartment of Anatomy, Osun State University, Osogbo, Osun State, NigeriaABSTRACT: Background: Early signs of neurodegenerative events of Alzheimer's disease manifest within the hippocampus and presents as cognitive and memory impairment. Aluminium-chloride (AlCl3), a neurotoxicant interferes with the structure and functions of the hippocampus as well as its neurogenesis, thereby causing cognitive and memory impairment. Buchholzia coriacea (BC), a plant of nutraceutical value is traditionally reputed to boost memory and cognitive functions. This study elucidated the neuroprotective role of Buchholzia coriacea seed extract on AlCl3-induced hippocampal neuronal damage in Wistar rat model by examining the biochemical, histological, immunohistochemical, and neurobehavioural changes. Methods: Twenty-five male Wistar rats were randomly assigned into five groups A-E (n = 5). Group A served as the control, groups B-E were given 200 mg/kg of AlCl3 for 14 days and then received 2 mLs/kg distilled water, 50mg/kg BC, 100mg/kg BC and 2.5mg/kg donepezil respectively for 14 days orally. Glutathione and neurotransmitters (Glutamate, dopamine, and acetylcholine) levels, G6PDH and neurobehavioral activities, as well as histological (H and E, LFB and Cresyl violet stains) and immunohistochemical (ionized calcium-binding adapter molecule 1, Iba-1) changes were evaluated Results: AlCl3 impaired spatial working memory with observable improvements in the treated groups. Enzymatic activity and neurotransmitter levels were augmented in the group treated with the highest dose of BC compared to the control. Histological assessment showed that BC high-dose mitigated neurodegenerative changes in the CA3 hippocampal subfield. Conclusion: Taken together, BC exhibited neuroprotective ability on AlCl3-induced CA3 hippocampal field neuronal damage and demonstrated memory impairment reversing ability.http://www.sciencedirect.com/science/article/pii/S2667031321000865Aluminium chlorideCA3HippocampusBuchholzia coriaceaAlzheimer's diseaseWistar rats |
| spellingShingle | Stephen Taiye Adelodun Oluwadamilola Adunni Ishola Ayodeji Zabdiel Abijo Sunday Yinka Olatunji Joshua Oladele Owolabi John Afees Olanrewaju Damilare Adedayo Adekomi Aluminium chloride-induced hippocampal damage: CA3 hippocampal subfield involvement and the neuroprotective role of Buchholzia coriacea ethanolic seed extract Phytomedicine Plus Aluminium chloride CA3 Hippocampus Buchholzia coriacea Alzheimer's disease Wistar rats |
| title | Aluminium chloride-induced hippocampal damage: CA3 hippocampal subfield involvement and the neuroprotective role of Buchholzia coriacea ethanolic seed extract |
| title_full | Aluminium chloride-induced hippocampal damage: CA3 hippocampal subfield involvement and the neuroprotective role of Buchholzia coriacea ethanolic seed extract |
| title_fullStr | Aluminium chloride-induced hippocampal damage: CA3 hippocampal subfield involvement and the neuroprotective role of Buchholzia coriacea ethanolic seed extract |
| title_full_unstemmed | Aluminium chloride-induced hippocampal damage: CA3 hippocampal subfield involvement and the neuroprotective role of Buchholzia coriacea ethanolic seed extract |
| title_short | Aluminium chloride-induced hippocampal damage: CA3 hippocampal subfield involvement and the neuroprotective role of Buchholzia coriacea ethanolic seed extract |
| title_sort | aluminium chloride induced hippocampal damage ca3 hippocampal subfield involvement and the neuroprotective role of buchholzia coriacea ethanolic seed extract |
| topic | Aluminium chloride CA3 Hippocampus Buchholzia coriacea Alzheimer's disease Wistar rats |
| url | http://www.sciencedirect.com/science/article/pii/S2667031321000865 |
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