Data-driven classification of prediabetes using cardiometabolic biomarkers: Data from National Health and Nutrition Examination Survey 2007–2016
BackgroundCluster analyses have proposed different prediabetes phenotypes using glycemic parameters, body fat distribution, liver fat content, and insulin sensitivity. We aimed at classifying the subjects with prediabetes using cluster analysis and exploring the associations between prediabetes clus...
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.937942/full |
| _version_ | 1798041883153268736 |
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| author | Yan Jiang Jinying Xia Caiyan Che Yongning Wei |
| author_facet | Yan Jiang Jinying Xia Caiyan Che Yongning Wei |
| author_sort | Yan Jiang |
| collection | DOAJ |
| description | BackgroundCluster analyses have proposed different prediabetes phenotypes using glycemic parameters, body fat distribution, liver fat content, and insulin sensitivity. We aimed at classifying the subjects with prediabetes using cluster analysis and exploring the associations between prediabetes clusters with hypertension and kidney function.MethodsPatients with prediabetes in the National Health and Nutrition Examination Survey (NHANES) underwent comprehensive phenotyping and physical and laboratory variable assessment. We identified six clusters using consensus clustering analysis based on the measurements representing the body fat, glycemic status, pancreatic islet function, blood lipids, and liver function. Differences in the characteristics and prevalence of hypertension, decreased estimated glomerular filtration rate (eGFR), and increased albumin-to-creatinine ratio (ACR) were compared between clusters.ResultsA total of 4,385 subjects with prediabetes were classified into six clusters of distinctive patterns by manifesting higher or lower levels of certain metabolic parameters in each cluster. Subjects with prediabetes in cluster 1 had the lowest prevalence of hypertension, decreased eGFR, and increased ACR, whereas these were much higher in cluster 5 and cluster 6. Except for cluster 3, all the other clusters had significantly increased odds ratio (OR) of hypertension as compared with cluster 1. Compared with cluster 1, all the other clusters presented significantly increased ORs of decreased eGFR. There were also significantly higher ORs of increased ACR for cluster 5 (OR 1.95, 95% confidence interval [CI] 1.09–3.51) and cluster 6 (OR 2.02, 95%CI = 1.15–3.52) compared with cluster 1.ConclusionWe stratified subjects with prediabetes into six subgroups with different characteristics. With further development and validation, such approaches might guide early intervention on the risk factors for the subjects with prediabetes who would benefit most. |
| first_indexed | 2024-04-11T22:27:45Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T22:27:45Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-b1ef0d94f9054a9da3d385f0c3f52f8c2022-12-22T03:59:36ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-08-011310.3389/fendo.2022.937942937942Data-driven classification of prediabetes using cardiometabolic biomarkers: Data from National Health and Nutrition Examination Survey 2007–2016Yan Jiang0Jinying Xia1Caiyan Che2Yongning Wei3Medical Department, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, ChinaDepartment of Endocrinology, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, ChinaMedical Department, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, ChinaDepartment of Hepatic Neoplasms, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, ChinaBackgroundCluster analyses have proposed different prediabetes phenotypes using glycemic parameters, body fat distribution, liver fat content, and insulin sensitivity. We aimed at classifying the subjects with prediabetes using cluster analysis and exploring the associations between prediabetes clusters with hypertension and kidney function.MethodsPatients with prediabetes in the National Health and Nutrition Examination Survey (NHANES) underwent comprehensive phenotyping and physical and laboratory variable assessment. We identified six clusters using consensus clustering analysis based on the measurements representing the body fat, glycemic status, pancreatic islet function, blood lipids, and liver function. Differences in the characteristics and prevalence of hypertension, decreased estimated glomerular filtration rate (eGFR), and increased albumin-to-creatinine ratio (ACR) were compared between clusters.ResultsA total of 4,385 subjects with prediabetes were classified into six clusters of distinctive patterns by manifesting higher or lower levels of certain metabolic parameters in each cluster. Subjects with prediabetes in cluster 1 had the lowest prevalence of hypertension, decreased eGFR, and increased ACR, whereas these were much higher in cluster 5 and cluster 6. Except for cluster 3, all the other clusters had significantly increased odds ratio (OR) of hypertension as compared with cluster 1. Compared with cluster 1, all the other clusters presented significantly increased ORs of decreased eGFR. There were also significantly higher ORs of increased ACR for cluster 5 (OR 1.95, 95% confidence interval [CI] 1.09–3.51) and cluster 6 (OR 2.02, 95%CI = 1.15–3.52) compared with cluster 1.ConclusionWe stratified subjects with prediabetes into six subgroups with different characteristics. With further development and validation, such approaches might guide early intervention on the risk factors for the subjects with prediabetes who would benefit most.https://www.frontiersin.org/articles/10.3389/fendo.2022.937942/fullprediabeteshypertensionestimated glomerular filtration rateconsensus clustering analysisalbumin to creatinine ratio |
| spellingShingle | Yan Jiang Jinying Xia Caiyan Che Yongning Wei Data-driven classification of prediabetes using cardiometabolic biomarkers: Data from National Health and Nutrition Examination Survey 2007–2016 Frontiers in Endocrinology prediabetes hypertension estimated glomerular filtration rate consensus clustering analysis albumin to creatinine ratio |
| title | Data-driven classification of prediabetes using cardiometabolic biomarkers: Data from National Health and Nutrition Examination Survey 2007–2016 |
| title_full | Data-driven classification of prediabetes using cardiometabolic biomarkers: Data from National Health and Nutrition Examination Survey 2007–2016 |
| title_fullStr | Data-driven classification of prediabetes using cardiometabolic biomarkers: Data from National Health and Nutrition Examination Survey 2007–2016 |
| title_full_unstemmed | Data-driven classification of prediabetes using cardiometabolic biomarkers: Data from National Health and Nutrition Examination Survey 2007–2016 |
| title_short | Data-driven classification of prediabetes using cardiometabolic biomarkers: Data from National Health and Nutrition Examination Survey 2007–2016 |
| title_sort | data driven classification of prediabetes using cardiometabolic biomarkers data from national health and nutrition examination survey 2007 2016 |
| topic | prediabetes hypertension estimated glomerular filtration rate consensus clustering analysis albumin to creatinine ratio |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.937942/full |
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