Research progress on the relationship between autophagy and chronic complications of diabetes
Diabetes is a common metabolic disease whose hyperglycemic state can induce diverse complications and even threaten human health and life security. Currently, the treatment of diabetes is restricted to drugs that regulate blood glucose and have certain accompanying side effects. Autophagy, a researc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.956344/full |
| _version_ | 1818490090199973888 |
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| author | Xia Ge Ling Wang Aihua Fei Shandong Ye Qingping Zhang |
| author_facet | Xia Ge Ling Wang Aihua Fei Shandong Ye Qingping Zhang |
| author_sort | Xia Ge |
| collection | DOAJ |
| description | Diabetes is a common metabolic disease whose hyperglycemic state can induce diverse complications and even threaten human health and life security. Currently, the treatment of diabetes is restricted to drugs that regulate blood glucose and have certain accompanying side effects. Autophagy, a research hotspot, has been proven to be involved in the occurrence and progression of the chronic complications of diabetes. Autophagy, as an essential organismal defense mechanism, refers to the wrapping of cytoplasmic proteins, broken organelles or pathogens by vesicles, which are then degraded by lysosomes to maintain the stability of the intracellular environment. Here, we review the relevant aspects of autophagy and the molecular mechanisms of autophagy in diabetic chronic complications, and further analyze the impact of improving autophagy on diabetic chronic complications, which will contribute to a new direction for further prevention and treatment of diabetic chronic complications. |
| first_indexed | 2024-12-10T17:12:44Z |
| format | Article |
| id | doaj.art-b1efc1758dc74f899efd2713fa6ed9eb |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-10T17:12:44Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-b1efc1758dc74f899efd2713fa6ed9eb2022-12-22T01:40:16ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-08-011310.3389/fphys.2022.956344956344Research progress on the relationship between autophagy and chronic complications of diabetesXia Ge0Ling Wang1Aihua Fei2Shandong Ye3Qingping Zhang4Department of Endocrinology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaGraduate School of Anhui University of Chinese Medicine, Hefei, ChinaDepartment of Endocrinology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, ChinaDepartment of Endocrinology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, ChinaCollege of Acupuncture-Moxibustion and Tuina, Anhui University of Chinese Medicine, Hefei, ChinaDiabetes is a common metabolic disease whose hyperglycemic state can induce diverse complications and even threaten human health and life security. Currently, the treatment of diabetes is restricted to drugs that regulate blood glucose and have certain accompanying side effects. Autophagy, a research hotspot, has been proven to be involved in the occurrence and progression of the chronic complications of diabetes. Autophagy, as an essential organismal defense mechanism, refers to the wrapping of cytoplasmic proteins, broken organelles or pathogens by vesicles, which are then degraded by lysosomes to maintain the stability of the intracellular environment. Here, we review the relevant aspects of autophagy and the molecular mechanisms of autophagy in diabetic chronic complications, and further analyze the impact of improving autophagy on diabetic chronic complications, which will contribute to a new direction for further prevention and treatment of diabetic chronic complications.https://www.frontiersin.org/articles/10.3389/fphys.2022.956344/fullautophagychronic complicationsdiabetes drugmolecular mechanismregulation |
| spellingShingle | Xia Ge Ling Wang Aihua Fei Shandong Ye Qingping Zhang Research progress on the relationship between autophagy and chronic complications of diabetes Frontiers in Physiology autophagy chronic complications diabetes drug molecular mechanism regulation |
| title | Research progress on the relationship between autophagy and chronic complications of diabetes |
| title_full | Research progress on the relationship between autophagy and chronic complications of diabetes |
| title_fullStr | Research progress on the relationship between autophagy and chronic complications of diabetes |
| title_full_unstemmed | Research progress on the relationship between autophagy and chronic complications of diabetes |
| title_short | Research progress on the relationship between autophagy and chronic complications of diabetes |
| title_sort | research progress on the relationship between autophagy and chronic complications of diabetes |
| topic | autophagy chronic complications diabetes drug molecular mechanism regulation |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.956344/full |
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