Prognostic significance of HLA-G in patients with colorectal cancer: a meta-analysis and bioinformatics analysis
Abstract Purpose Human leukocyte antigen-G (HLA-G) has been reported to be aberrantly expressed in colorectal cancer (CRC); however, its prognostic value remains controversial. Hence, our meta-analysis aims to assess the prognostic value of HLA-G in CRC patients based on published literature and The...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-023-11522-w |
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| author | Yingying Zhang Siying He Lisha Yu Chao Shi Yanyue Zhang Shiyue Tang |
| author_facet | Yingying Zhang Siying He Lisha Yu Chao Shi Yanyue Zhang Shiyue Tang |
| author_sort | Yingying Zhang |
| collection | DOAJ |
| description | Abstract Purpose Human leukocyte antigen-G (HLA-G) has been reported to be aberrantly expressed in colorectal cancer (CRC); however, its prognostic value remains controversial. Hence, our meta-analysis aims to assess the prognostic value of HLA-G in CRC patients based on published literature and The Cancer Genome Atlas (TCGA) datasets. Methods A systematic search was conducted on relevant studies retrieved from four electronic databases including PubMed, Embase, Web of Science and Cochrane Library. Hazard ratios (HRs) with 95% confidence intervals (CIs) were recorded to be applied as effective values. Fixed-effects models or random-effects models were applied on the basis of the value of heterogeneity (I 2). Publication bias was analyzed by Begg’s and Egger’s tests. In addition, the results were validated by using TCGA datasets. Results Thirteen studies comprising 3896 patients were incorporated into this meta-analysis. The pooled results showed that HLA-G expression was significantly associated with poor overall survival (OS) in both the univariate analysis (HR = 1.44, 95% CI: 1.14–1.83, P = 0.002) and the multivariate analysis (HR = 1.55, 95% CI: 1.23–1.95, P < 0.001). Nevertheless, the expression of HLA-G is not related to age, sex, tumor type, tumor differentiation, TNM stage, or distant metastasis but lymph node metastasis. Notably, the prognosis of colorectal cancer was not consistent with the analysis result from TCGA data. Conclusion HLA-G expression was significantly related to poor OS in CRC according to the results of our meta-analysis. However, we found that the prognostic significance was inconsistent with our results according to the TCGA data in CRC. Hence, more research is still needed to further illustrate the prognostic role of HLA-G in CRC. |
| first_indexed | 2024-03-09T15:06:58Z |
| format | Article |
| id | doaj.art-b1f0710ab9d941cd9449c254c8def582 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-09T15:06:58Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-b1f0710ab9d941cd9449c254c8def5822023-11-26T13:36:18ZengBMCBMC Cancer1471-24072023-10-0123111710.1186/s12885-023-11522-wPrognostic significance of HLA-G in patients with colorectal cancer: a meta-analysis and bioinformatics analysisYingying Zhang0Siying He1Lisha Yu2Chao Shi3Yanyue Zhang4Shiyue Tang5Department of clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of MedicineDepartment of clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of MedicineDepartment of clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of MedicineDepartment of clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of MedicineDepartment of clinical Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of MedicineDepartment of Infectious Diseases, Affiliated Jinhua Hospital, Zhejiang University School of MedicineAbstract Purpose Human leukocyte antigen-G (HLA-G) has been reported to be aberrantly expressed in colorectal cancer (CRC); however, its prognostic value remains controversial. Hence, our meta-analysis aims to assess the prognostic value of HLA-G in CRC patients based on published literature and The Cancer Genome Atlas (TCGA) datasets. Methods A systematic search was conducted on relevant studies retrieved from four electronic databases including PubMed, Embase, Web of Science and Cochrane Library. Hazard ratios (HRs) with 95% confidence intervals (CIs) were recorded to be applied as effective values. Fixed-effects models or random-effects models were applied on the basis of the value of heterogeneity (I 2). Publication bias was analyzed by Begg’s and Egger’s tests. In addition, the results were validated by using TCGA datasets. Results Thirteen studies comprising 3896 patients were incorporated into this meta-analysis. The pooled results showed that HLA-G expression was significantly associated with poor overall survival (OS) in both the univariate analysis (HR = 1.44, 95% CI: 1.14–1.83, P = 0.002) and the multivariate analysis (HR = 1.55, 95% CI: 1.23–1.95, P < 0.001). Nevertheless, the expression of HLA-G is not related to age, sex, tumor type, tumor differentiation, TNM stage, or distant metastasis but lymph node metastasis. Notably, the prognosis of colorectal cancer was not consistent with the analysis result from TCGA data. Conclusion HLA-G expression was significantly related to poor OS in CRC according to the results of our meta-analysis. However, we found that the prognostic significance was inconsistent with our results according to the TCGA data in CRC. Hence, more research is still needed to further illustrate the prognostic role of HLA-G in CRC.https://doi.org/10.1186/s12885-023-11522-wColorectal cancerHLA-Gmeta-analysisPrognosis |
| spellingShingle | Yingying Zhang Siying He Lisha Yu Chao Shi Yanyue Zhang Shiyue Tang Prognostic significance of HLA-G in patients with colorectal cancer: a meta-analysis and bioinformatics analysis BMC Cancer Colorectal cancer HLA-G meta-analysis Prognosis |
| title | Prognostic significance of HLA-G in patients with colorectal cancer: a meta-analysis and bioinformatics analysis |
| title_full | Prognostic significance of HLA-G in patients with colorectal cancer: a meta-analysis and bioinformatics analysis |
| title_fullStr | Prognostic significance of HLA-G in patients with colorectal cancer: a meta-analysis and bioinformatics analysis |
| title_full_unstemmed | Prognostic significance of HLA-G in patients with colorectal cancer: a meta-analysis and bioinformatics analysis |
| title_short | Prognostic significance of HLA-G in patients with colorectal cancer: a meta-analysis and bioinformatics analysis |
| title_sort | prognostic significance of hla g in patients with colorectal cancer a meta analysis and bioinformatics analysis |
| topic | Colorectal cancer HLA-G meta-analysis Prognosis |
| url | https://doi.org/10.1186/s12885-023-11522-w |
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