Graft lymphoma in a kidney transplant recipient: a case report
Posttransplant lymphoproliferative disorders (PTLDs) are severe complications with heterogeneous clinical pictures involving abnormal lymphoproliferation in solid organ transplants and are known to be closely associated with Epstein-Barr virus (EBV) infection. Herein, we present a case of graft lymp...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society for Transplantation
2023-09-01
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| Series: | Korean Journal of Transplantation |
| Subjects: | |
| Online Access: | http://www.ekjt.org/journal/view.html?doi=10.4285/kjt.23.0035 |
| _version_ | 1797327323712716800 |
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| author | Ji Hyun Yeom Won Kim Kyung Pyo Kang Hyeongwan Kim Hee Chul Yu Hong Pil Hwang Byeoung Hoon Chung Kyu Yun Jang Sik Lee |
| author_facet | Ji Hyun Yeom Won Kim Kyung Pyo Kang Hyeongwan Kim Hee Chul Yu Hong Pil Hwang Byeoung Hoon Chung Kyu Yun Jang Sik Lee |
| author_sort | Ji Hyun Yeom |
| collection | DOAJ |
| description | Posttransplant lymphoproliferative disorders (PTLDs) are severe complications with heterogeneous clinical pictures involving abnormal lymphoproliferation in solid organ transplants and are known to be closely associated with Epstein-Barr virus (EBV) infection. Herein, we present a case of graft lymphoma in a febrile kidney transplant recipient. A 37-year-old woman was admitted with an abrupt 39 °C fever, mild graft discomfort, and gross hematuria. She had received deceased donor kidney transplantation 8 years earlier, but developed graft failure due to a recurrence of immunoglobulin A nephropathy. Laboratory tests revealed anemia and elevated levels of inflammatory markers. Enhanced abdominopelvic computed tomography showed graft swelling with perirenal fat stranding. Thus, we administered antibiotics for a urinary tract infection and increased the doses of steroids due to suspicion of graft intolerance syndrome. However, the patient's symptoms gradually worsened. Eventually, we performed graft nephrectomy and histologically confirmed EBV-positive diffuse large B cell lymphoma. We report a case in which a PTLD was considered in the differential diagnosis of a kidney transplant recipient with symptoms similar to those of a urinary tract infection or graft intolerance syndrome. |
| first_indexed | 2024-03-08T06:36:35Z |
| format | Article |
| id | doaj.art-b1f1297a2e374f418a861c574d1856f6 |
| institution | Directory Open Access Journal |
| issn | 2671-8790 |
| language | English |
| last_indexed | 2024-03-08T06:36:35Z |
| publishDate | 2023-09-01 |
| publisher | Korean Society for Transplantation |
| record_format | Article |
| series | Korean Journal of Transplantation |
| spelling | doaj.art-b1f1297a2e374f418a861c574d1856f62024-02-03T09:52:56ZengKorean Society for TransplantationKorean Journal of Transplantation2671-87902023-09-0137321621910.4285/kjt.23.0035kjt.23.0035Graft lymphoma in a kidney transplant recipient: a case reportJi Hyun Yeom0Won Kim1Kyung Pyo Kang2Hyeongwan Kim3Hee Chul Yu4Hong Pil Hwang5Byeoung Hoon Chung6Kyu Yun Jang7Sik Lee8Department of Internal Medicine, Jeonbuk National University Hospital, Jeonju, KoreaDepartment of Internal Medicine, Jeonbuk National University Hospital, Jeonju, KoreaDepartment of Internal Medicine, Jeonbuk National University Hospital, Jeonju, KoreaDepartment of Internal Medicine, Jeonbuk National University Hospital, Jeonju, KoreaBiomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju, KoreaBiomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju, KoreaBiomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju, KoreaBiomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju, KoreaDepartment of Internal Medicine, Jeonbuk National University Hospital, Jeonju, KoreaPosttransplant lymphoproliferative disorders (PTLDs) are severe complications with heterogeneous clinical pictures involving abnormal lymphoproliferation in solid organ transplants and are known to be closely associated with Epstein-Barr virus (EBV) infection. Herein, we present a case of graft lymphoma in a febrile kidney transplant recipient. A 37-year-old woman was admitted with an abrupt 39 °C fever, mild graft discomfort, and gross hematuria. She had received deceased donor kidney transplantation 8 years earlier, but developed graft failure due to a recurrence of immunoglobulin A nephropathy. Laboratory tests revealed anemia and elevated levels of inflammatory markers. Enhanced abdominopelvic computed tomography showed graft swelling with perirenal fat stranding. Thus, we administered antibiotics for a urinary tract infection and increased the doses of steroids due to suspicion of graft intolerance syndrome. However, the patient's symptoms gradually worsened. Eventually, we performed graft nephrectomy and histologically confirmed EBV-positive diffuse large B cell lymphoma. We report a case in which a PTLD was considered in the differential diagnosis of a kidney transplant recipient with symptoms similar to those of a urinary tract infection or graft intolerance syndrome.http://www.ekjt.org/journal/view.html?doi=10.4285/kjt.23.0035kidney transplantation; lymphoproliferative disorders; epstein-barr virus; case reports |
| spellingShingle | Ji Hyun Yeom Won Kim Kyung Pyo Kang Hyeongwan Kim Hee Chul Yu Hong Pil Hwang Byeoung Hoon Chung Kyu Yun Jang Sik Lee Graft lymphoma in a kidney transplant recipient: a case report Korean Journal of Transplantation kidney transplantation; lymphoproliferative disorders; epstein-barr virus; case reports |
| title | Graft lymphoma in a kidney transplant recipient: a case report |
| title_full | Graft lymphoma in a kidney transplant recipient: a case report |
| title_fullStr | Graft lymphoma in a kidney transplant recipient: a case report |
| title_full_unstemmed | Graft lymphoma in a kidney transplant recipient: a case report |
| title_short | Graft lymphoma in a kidney transplant recipient: a case report |
| title_sort | graft lymphoma in a kidney transplant recipient a case report |
| topic | kidney transplantation; lymphoproliferative disorders; epstein-barr virus; case reports |
| url | http://www.ekjt.org/journal/view.html?doi=10.4285/kjt.23.0035 |
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