Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation
It is unclear how translational efficiency and codon stringency affect zygotic genome activation and early embryonic development. Here they show that the zygotic gene BZW1 increases start codon stringency, which is important for preimplantation development.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34427-x |
| _version_ | 1811328481715290112 |
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| author | Jue Zhang Shuai-Bo Pi Nan Zhang Jing Guo Wei Zheng Lizhi Leng Ge Lin Heng-Yu Fan |
| author_facet | Jue Zhang Shuai-Bo Pi Nan Zhang Jing Guo Wei Zheng Lizhi Leng Ge Lin Heng-Yu Fan |
| author_sort | Jue Zhang |
| collection | DOAJ |
| description | It is unclear how translational efficiency and codon stringency affect zygotic genome activation and early embryonic development. Here they show that the zygotic gene BZW1 increases start codon stringency, which is important for preimplantation development. |
| first_indexed | 2024-04-13T15:25:53Z |
| format | Article |
| id | doaj.art-b1f151c5f5904dd9b80610390a7f96b6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T15:25:53Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b1f151c5f5904dd9b80610390a7f96b62022-12-22T02:41:30ZengNature PortfolioNature Communications2041-17232022-11-0113111510.1038/s41467-022-34427-xTranslation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG InitiationJue Zhang0Shuai-Bo Pi1Nan Zhang2Jing Guo3Wei Zheng4Lizhi Leng5Ge Lin6Heng-Yu Fan7Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYALife Sciences Institute, Zhejiang UniversityNHC Key Laboratory of Human Stem and Reproductive Engineering, School of Basic Medical Science, Central South UniversityClinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYAClinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYAClinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYAClinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYALife Sciences Institute, Zhejiang UniversityIt is unclear how translational efficiency and codon stringency affect zygotic genome activation and early embryonic development. Here they show that the zygotic gene BZW1 increases start codon stringency, which is important for preimplantation development.https://doi.org/10.1038/s41467-022-34427-x |
| spellingShingle | Jue Zhang Shuai-Bo Pi Nan Zhang Jing Guo Wei Zheng Lizhi Leng Ge Lin Heng-Yu Fan Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation Nature Communications |
| title | Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation |
| title_full | Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation |
| title_fullStr | Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation |
| title_full_unstemmed | Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation |
| title_short | Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation |
| title_sort | translation regulatory factor bzw1 regulates preimplantation embryo development and compaction by restricting global non aug initiation |
| url | https://doi.org/10.1038/s41467-022-34427-x |
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