Preparation, characterization, antioxidant activity of 1-(2-furoyl) thiourea derivatives and study the molecular docking of them as potent inhibitors of Urease enzyme
In this work, we synthesized thirteen compounds of 1-(2-furoyl)thiourea derivatives 1-13 by conversion of 2-furoyl chloride to 2-furoyl isothiocyanate by reacting it with potassium thiocyanate in dry acetone in a quite short reflux time then, in the same pot, different of (primary and secondary ami...
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| Format: | Article |
| Language: | Arabic |
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College of Science for Women, University of Baghdad
2023-06-01
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| Series: | Baghdad Science Journal |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7745 |
| _version_ | 1797792246886563840 |
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| author | Oday H. R. Al-Jeilawi Abdullah Qays Oleiwi |
| author_facet | Oday H. R. Al-Jeilawi Abdullah Qays Oleiwi |
| author_sort | Oday H. R. Al-Jeilawi |
| collection | DOAJ |
| description |
In this work, we synthesized thirteen compounds of 1-(2-furoyl)thiourea derivatives 1-13 by conversion of 2-furoyl chloride to 2-furoyl isothiocyanate by reacting it with potassium thiocyanate in dry acetone in a quite short reflux time then, in the same pot, different of (primary and secondary amines) were added individually to achieve thiourea derivatives. The products were characterized spectroscopically using (FT-IR, 1H NMR and 13C NMR) techniques. Some of them were evaluated as antioxidant agents using DPPH radical scavenging method, and all were examined theoretically as enzyme inhibitors against Bacillus pasteurii urease (pdb id: 4ubp) and by studying molecular docking using Autodock (4.2.6) software.
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| first_indexed | 2024-03-13T02:30:27Z |
| format | Article |
| id | doaj.art-b1f41971cdb74bdb80c0a40e0701e805 |
| institution | Directory Open Access Journal |
| issn | 2078-8665 2411-7986 |
| language | Arabic |
| last_indexed | 2024-03-13T02:30:27Z |
| publishDate | 2023-06-01 |
| publisher | College of Science for Women, University of Baghdad |
| record_format | Article |
| series | Baghdad Science Journal |
| spelling | doaj.art-b1f41971cdb74bdb80c0a40e0701e8052023-06-29T19:47:38ZaraCollege of Science for Women, University of BaghdadBaghdad Science Journal2078-86652411-79862023-06-01203(Suppl.)10.21123/bsj.2023.7745Preparation, characterization, antioxidant activity of 1-(2-furoyl) thiourea derivatives and study the molecular docking of them as potent inhibitors of Urease enzymeOday H. R. Al-Jeilawi 0Abdullah Qays Oleiwi1Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq.Department of Chemistry, College of Science, University of Anbar, Ramadi, Iraq. In this work, we synthesized thirteen compounds of 1-(2-furoyl)thiourea derivatives 1-13 by conversion of 2-furoyl chloride to 2-furoyl isothiocyanate by reacting it with potassium thiocyanate in dry acetone in a quite short reflux time then, in the same pot, different of (primary and secondary amines) were added individually to achieve thiourea derivatives. The products were characterized spectroscopically using (FT-IR, 1H NMR and 13C NMR) techniques. Some of them were evaluated as antioxidant agents using DPPH radical scavenging method, and all were examined theoretically as enzyme inhibitors against Bacillus pasteurii urease (pdb id: 4ubp) and by studying molecular docking using Autodock (4.2.6) software. https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/77452-furoyl chloride, Antioxidant, Molecular docking, Thiourea derivatives, Urease |
| spellingShingle | Oday H. R. Al-Jeilawi Abdullah Qays Oleiwi Preparation, characterization, antioxidant activity of 1-(2-furoyl) thiourea derivatives and study the molecular docking of them as potent inhibitors of Urease enzyme Baghdad Science Journal 2-furoyl chloride, Antioxidant, Molecular docking, Thiourea derivatives, Urease |
| title | Preparation, characterization, antioxidant activity of 1-(2-furoyl) thiourea derivatives and study the molecular docking of them as potent inhibitors of Urease enzyme |
| title_full | Preparation, characterization, antioxidant activity of 1-(2-furoyl) thiourea derivatives and study the molecular docking of them as potent inhibitors of Urease enzyme |
| title_fullStr | Preparation, characterization, antioxidant activity of 1-(2-furoyl) thiourea derivatives and study the molecular docking of them as potent inhibitors of Urease enzyme |
| title_full_unstemmed | Preparation, characterization, antioxidant activity of 1-(2-furoyl) thiourea derivatives and study the molecular docking of them as potent inhibitors of Urease enzyme |
| title_short | Preparation, characterization, antioxidant activity of 1-(2-furoyl) thiourea derivatives and study the molecular docking of them as potent inhibitors of Urease enzyme |
| title_sort | preparation characterization antioxidant activity of 1 2 furoyl thiourea derivatives and study the molecular docking of them as potent inhibitors of urease enzyme |
| topic | 2-furoyl chloride, Antioxidant, Molecular docking, Thiourea derivatives, Urease |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7745 |
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