The role of the interferon gamma release assay in assessing recent tuberculosis transmission in a hospital incident.
In 2007, an extensive contact screening investigation into onward transmission of tuberculosis was instigated at a hospital in Northern Ireland following diagnosis of pulmonary multi-drug resistant TB in a healthcare worker. Interferon gamma release assays (IGRAs) were used to test 333 patients and...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3113857?pdf=render |
| _version_ | 1828825234852020224 |
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| author | Louise Bradshaw Elizabeth Davies Michael Devine Peter Flanagan Paul Kelly Kevin O'Connor Francis Drobniewski Vladislav Nikolayevskyy Ibrahim Abubakar |
| author_facet | Louise Bradshaw Elizabeth Davies Michael Devine Peter Flanagan Paul Kelly Kevin O'Connor Francis Drobniewski Vladislav Nikolayevskyy Ibrahim Abubakar |
| author_sort | Louise Bradshaw |
| collection | DOAJ |
| description | In 2007, an extensive contact screening investigation into onward transmission of tuberculosis was instigated at a hospital in Northern Ireland following diagnosis of pulmonary multi-drug resistant TB in a healthcare worker. Interferon gamma release assays (IGRAs) were used to test 333 patients and 98 staff. We investigated for evidence of onward transmission and recent infection based on analysis of clinical, demographic and IGRA data. We also described within-patient variability of IGRA results. Among patients and staff, increasing age of patients was the only factor associated with IGRA positivity. Greatest within-subject variability of IU/mL in serially-tested patients/staff was seen in those with a positive IGRA test and this did not correlate with increased exposure to the index case. IGRA positivity being largely explained by increasing age in patients and previous TB contact in staff lends weight to the conclusion that IGRA positivity reflected previous infection rather than recent transmission. |
| first_indexed | 2024-12-12T14:12:12Z |
| format | Article |
| id | doaj.art-b1f4be406e17470f8287bc196f736a02 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T14:12:12Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b1f4be406e17470f8287bc196f736a022022-12-22T00:22:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0166e2077010.1371/journal.pone.0020770The role of the interferon gamma release assay in assessing recent tuberculosis transmission in a hospital incident.Louise BradshawElizabeth DaviesMichael DevinePeter FlanaganPaul KellyKevin O'ConnorFrancis DrobniewskiVladislav NikolayevskyyIbrahim AbubakarIn 2007, an extensive contact screening investigation into onward transmission of tuberculosis was instigated at a hospital in Northern Ireland following diagnosis of pulmonary multi-drug resistant TB in a healthcare worker. Interferon gamma release assays (IGRAs) were used to test 333 patients and 98 staff. We investigated for evidence of onward transmission and recent infection based on analysis of clinical, demographic and IGRA data. We also described within-patient variability of IGRA results. Among patients and staff, increasing age of patients was the only factor associated with IGRA positivity. Greatest within-subject variability of IU/mL in serially-tested patients/staff was seen in those with a positive IGRA test and this did not correlate with increased exposure to the index case. IGRA positivity being largely explained by increasing age in patients and previous TB contact in staff lends weight to the conclusion that IGRA positivity reflected previous infection rather than recent transmission.http://europepmc.org/articles/PMC3113857?pdf=render |
| spellingShingle | Louise Bradshaw Elizabeth Davies Michael Devine Peter Flanagan Paul Kelly Kevin O'Connor Francis Drobniewski Vladislav Nikolayevskyy Ibrahim Abubakar The role of the interferon gamma release assay in assessing recent tuberculosis transmission in a hospital incident. PLoS ONE |
| title | The role of the interferon gamma release assay in assessing recent tuberculosis transmission in a hospital incident. |
| title_full | The role of the interferon gamma release assay in assessing recent tuberculosis transmission in a hospital incident. |
| title_fullStr | The role of the interferon gamma release assay in assessing recent tuberculosis transmission in a hospital incident. |
| title_full_unstemmed | The role of the interferon gamma release assay in assessing recent tuberculosis transmission in a hospital incident. |
| title_short | The role of the interferon gamma release assay in assessing recent tuberculosis transmission in a hospital incident. |
| title_sort | role of the interferon gamma release assay in assessing recent tuberculosis transmission in a hospital incident |
| url | http://europepmc.org/articles/PMC3113857?pdf=render |
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