Pregnancy after renal transplantation: Effects on mother, child, and renal graft function
The aim of this study was to report our experience of pregnancy in renal transplant (RT) patients and its medium and long-term effects on the renal graft as well as the maternal fetal complications. We studied 21 pregnancies in 12 RT patients with mean age of 29.9 ± 5.3 years. The mean duration of R...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Saudi Journal of Kidney Diseases and Transplantation |
| Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2016;volume=27;issue=2;spage=227;epage=232;aulast=El |
| _version_ | 1811331109536923648 |
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| author | Siham El Houssni Siham Sabri Loubna Benamar Naima Ouzeddoun Rabia Bayahia Hakima Rhou |
| author_facet | Siham El Houssni Siham Sabri Loubna Benamar Naima Ouzeddoun Rabia Bayahia Hakima Rhou |
| author_sort | Siham El Houssni |
| collection | DOAJ |
| description | The aim of this study was to report our experience of pregnancy in renal transplant (RT) patients and its medium and long-term effects on the renal graft as well as the maternal fetal complications. We studied 21 pregnancies in 12 RT patients with mean age of 29.9 ± 5.3 years. The mean duration of RT to 1 st pregnancy was 42 (21-68.5) months and the median follow-up period was 112.5 (138-165) months. The pregnancy was planned in 28.6% of the cases. At the time of the diagnosis of the pregnancy, all the patients were maintained on corticosteroids and cyclosporine, 14.3% of the patients were on mycophenolate mofetil, and 71.4% of the patients were on azathioprine. The high blood pressure was present before the pregnancy in 33.3% of the patients. During pregnancy, proteinuria appeared in 20% of the cases, urinary tract infection in 33.3%, and preeclampsia in 5%. Anemia was present in all the patients during pregnancy. The doses of cyclosporine were increased during pregnancy. The mean term of delivery was 37 ± 2 weeks. Premature delivery was observed in 19% of the cases, fetal death in utero in 10%, and abortion in 15%. The number of living children was 16, with a mean birth weight of 3014 ± 515 g; the weight was lower than 2500 g in three (15%) cases. In the long-term follow-up, we noticed two cases of acute rejection related to patients′ noncompliance, and four cases of chronic allograft nephropathy, without a switch to dialysis. We conclude that pregnancy in RT patients requires multidisciplinary care because of the increased risks of maternal and fetal complications. Each pregnancy needs to be planned; all parameters have to be studied and evaluated in order to allow for optimization of outcome and minimization of complications. |
| first_indexed | 2024-04-13T16:14:10Z |
| format | Article |
| id | doaj.art-b1f5ccab02c9499894eed0dcf325c8f1 |
| institution | Directory Open Access Journal |
| issn | 1319-2442 |
| language | English |
| last_indexed | 2024-04-13T16:14:10Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Kidney Diseases and Transplantation |
| spelling | doaj.art-b1f5ccab02c9499894eed0dcf325c8f12022-12-22T02:40:07ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422016-01-0127222723210.4103/1319-2442.178204Pregnancy after renal transplantation: Effects on mother, child, and renal graft functionSiham El HoussniSiham SabriLoubna BenamarNaima OuzeddounRabia BayahiaHakima RhouThe aim of this study was to report our experience of pregnancy in renal transplant (RT) patients and its medium and long-term effects on the renal graft as well as the maternal fetal complications. We studied 21 pregnancies in 12 RT patients with mean age of 29.9 ± 5.3 years. The mean duration of RT to 1 st pregnancy was 42 (21-68.5) months and the median follow-up period was 112.5 (138-165) months. The pregnancy was planned in 28.6% of the cases. At the time of the diagnosis of the pregnancy, all the patients were maintained on corticosteroids and cyclosporine, 14.3% of the patients were on mycophenolate mofetil, and 71.4% of the patients were on azathioprine. The high blood pressure was present before the pregnancy in 33.3% of the patients. During pregnancy, proteinuria appeared in 20% of the cases, urinary tract infection in 33.3%, and preeclampsia in 5%. Anemia was present in all the patients during pregnancy. The doses of cyclosporine were increased during pregnancy. The mean term of delivery was 37 ± 2 weeks. Premature delivery was observed in 19% of the cases, fetal death in utero in 10%, and abortion in 15%. The number of living children was 16, with a mean birth weight of 3014 ± 515 g; the weight was lower than 2500 g in three (15%) cases. In the long-term follow-up, we noticed two cases of acute rejection related to patients′ noncompliance, and four cases of chronic allograft nephropathy, without a switch to dialysis. We conclude that pregnancy in RT patients requires multidisciplinary care because of the increased risks of maternal and fetal complications. Each pregnancy needs to be planned; all parameters have to be studied and evaluated in order to allow for optimization of outcome and minimization of complications.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2016;volume=27;issue=2;spage=227;epage=232;aulast=El |
| spellingShingle | Siham El Houssni Siham Sabri Loubna Benamar Naima Ouzeddoun Rabia Bayahia Hakima Rhou Pregnancy after renal transplantation: Effects on mother, child, and renal graft function Saudi Journal of Kidney Diseases and Transplantation |
| title | Pregnancy after renal transplantation: Effects on mother, child, and renal graft function |
| title_full | Pregnancy after renal transplantation: Effects on mother, child, and renal graft function |
| title_fullStr | Pregnancy after renal transplantation: Effects on mother, child, and renal graft function |
| title_full_unstemmed | Pregnancy after renal transplantation: Effects on mother, child, and renal graft function |
| title_short | Pregnancy after renal transplantation: Effects on mother, child, and renal graft function |
| title_sort | pregnancy after renal transplantation effects on mother child and renal graft function |
| url | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2016;volume=27;issue=2;spage=227;epage=232;aulast=El |
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