Efficacy and Safety of Denosumab in Osteoporosis or Low Bone Mineral Density Postmenopausal Women
Denosumab, a human monoclonal antibody, acts against the receptor activator of nuclear factor-κB ligand and is a promising antiresorptive agent in patients with osteoporosis. This study aimed to update the efficacy and safety of denosumab vs. placebo in osteoporosis or low bone mineral density (BMD)...
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.588095/full |
| _version_ | 1818926671865053184 |
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| author | Yi Chen Jun Zhu Yiqin Zhou Jinhui Peng Bo Wang |
| author_facet | Yi Chen Jun Zhu Yiqin Zhou Jinhui Peng Bo Wang |
| author_sort | Yi Chen |
| collection | DOAJ |
| description | Denosumab, a human monoclonal antibody, acts against the receptor activator of nuclear factor-κB ligand and is a promising antiresorptive agent in patients with osteoporosis. This study aimed to update the efficacy and safety of denosumab vs. placebo in osteoporosis or low bone mineral density (BMD) postmenopausal women. PubMed, Embase, Cochrane library, and ClinicalTrials.gov were searched for randomized controlled trials (RCTs) reporting the efficacy and safety data of denosumab vs. placebo in osteoporosis or low BMD postmenopausal women. A random-effects model was used to calculate pooled weight mean differences (WMDs) or relative risks (RRs) with corresponding 95% confidence intervals (CIs) for treatment effectiveness of denosumab vs. placebo. Eleven RCTs including 12,013 postmenopausal women with osteoporosis or low BMD were preferred for the final meta-analysis. The summary results indicated that the percentage change of BMD in the denosumab group was greater than that of BMD in placebo at 1/3 radius (WMD: 3.43; 95%CI: 3.24–3.62; p < 0.001), femoral neck (WMD: 3.05; 95%CI: 1.78–4.33; p < 0.001), lumbar spine (WMD: 6.25; 95%CI: 4.59–7.92; p < 0.001), total hip (WMD: 4.36; 95%CI: 4.07–4.66; p < 0.001), trochanter (WMD: 6.00; 95%CI: 5.95–6.05; p < 0.001), and total body (WMD: 3.20; 95%CI: 2.03–4.38; p < 0.001). Moreover, denosumab therapy significantly reduced the risk of clinical fractures (RR: 0.57; 95%CI: 0.51–0.63; p < 0.001), nonvertebral fracture (RR: 0.83; 95%CI: 0.70–0.97; p = 0.018), vertebral fracture (RR: 0.32; 95%CI: 0.25–0.40; p < 0.001), and hip fracture (RR: 0.61; 95%CI: 0.37–0.98; p = 0.042). Finally, denosumab did not cause excess risks of adverse events. These findings suggested that postmenopausal women receiving denosumab had increased BMDs and reduced fractures at various sites without inducing any adverse events. |
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| spelling | doaj.art-b1f8f701730c44359757911643e46e0b2022-12-21T19:55:46ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-04-011210.3389/fphar.2021.588095588095Efficacy and Safety of Denosumab in Osteoporosis or Low Bone Mineral Density Postmenopausal WomenYi ChenJun ZhuYiqin ZhouJinhui PengBo WangDenosumab, a human monoclonal antibody, acts against the receptor activator of nuclear factor-κB ligand and is a promising antiresorptive agent in patients with osteoporosis. This study aimed to update the efficacy and safety of denosumab vs. placebo in osteoporosis or low bone mineral density (BMD) postmenopausal women. PubMed, Embase, Cochrane library, and ClinicalTrials.gov were searched for randomized controlled trials (RCTs) reporting the efficacy and safety data of denosumab vs. placebo in osteoporosis or low BMD postmenopausal women. A random-effects model was used to calculate pooled weight mean differences (WMDs) or relative risks (RRs) with corresponding 95% confidence intervals (CIs) for treatment effectiveness of denosumab vs. placebo. Eleven RCTs including 12,013 postmenopausal women with osteoporosis or low BMD were preferred for the final meta-analysis. The summary results indicated that the percentage change of BMD in the denosumab group was greater than that of BMD in placebo at 1/3 radius (WMD: 3.43; 95%CI: 3.24–3.62; p < 0.001), femoral neck (WMD: 3.05; 95%CI: 1.78–4.33; p < 0.001), lumbar spine (WMD: 6.25; 95%CI: 4.59–7.92; p < 0.001), total hip (WMD: 4.36; 95%CI: 4.07–4.66; p < 0.001), trochanter (WMD: 6.00; 95%CI: 5.95–6.05; p < 0.001), and total body (WMD: 3.20; 95%CI: 2.03–4.38; p < 0.001). Moreover, denosumab therapy significantly reduced the risk of clinical fractures (RR: 0.57; 95%CI: 0.51–0.63; p < 0.001), nonvertebral fracture (RR: 0.83; 95%CI: 0.70–0.97; p = 0.018), vertebral fracture (RR: 0.32; 95%CI: 0.25–0.40; p < 0.001), and hip fracture (RR: 0.61; 95%CI: 0.37–0.98; p = 0.042). Finally, denosumab did not cause excess risks of adverse events. These findings suggested that postmenopausal women receiving denosumab had increased BMDs and reduced fractures at various sites without inducing any adverse events.https://www.frontiersin.org/articles/10.3389/fphar.2021.588095/fulldenosumabosteoporosisbone mineral densitypostmenopausal womenefficacysafety |
| spellingShingle | Yi Chen Jun Zhu Yiqin Zhou Jinhui Peng Bo Wang Efficacy and Safety of Denosumab in Osteoporosis or Low Bone Mineral Density Postmenopausal Women Frontiers in Pharmacology denosumab osteoporosis bone mineral density postmenopausal women efficacy safety |
| title | Efficacy and Safety of Denosumab in Osteoporosis or Low Bone Mineral Density Postmenopausal Women |
| title_full | Efficacy and Safety of Denosumab in Osteoporosis or Low Bone Mineral Density Postmenopausal Women |
| title_fullStr | Efficacy and Safety of Denosumab in Osteoporosis or Low Bone Mineral Density Postmenopausal Women |
| title_full_unstemmed | Efficacy and Safety of Denosumab in Osteoporosis or Low Bone Mineral Density Postmenopausal Women |
| title_short | Efficacy and Safety of Denosumab in Osteoporosis or Low Bone Mineral Density Postmenopausal Women |
| title_sort | efficacy and safety of denosumab in osteoporosis or low bone mineral density postmenopausal women |
| topic | denosumab osteoporosis bone mineral density postmenopausal women efficacy safety |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.588095/full |
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