1-<i>O</i>-alkyl-glycerols from Squid <i>Berryteuthis magister</i> Reduce Inflammation and Modify Fatty Acid and Plasmalogen Metabolism in Asthma Associated with Obesity
Asthma associated with obesity is considered the most severe phenotype and can be challenging to manage with standard medications. Marine-derived 1-<i>O</i>-alkyl-glycerols (AGs), as precursors for plasmalogen synthesis, have high biological activity, making them a promising substance fo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/21/6/351 |
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| author | Yulia Denisenko Tatyana Novgorodtseva Marina Antonyuk Alla Yurenko Tatyana Gvozdenko Sergey Kasyanov Ekaterina Ermolenko Ruslan Sultanov |
| author_facet | Yulia Denisenko Tatyana Novgorodtseva Marina Antonyuk Alla Yurenko Tatyana Gvozdenko Sergey Kasyanov Ekaterina Ermolenko Ruslan Sultanov |
| author_sort | Yulia Denisenko |
| collection | DOAJ |
| description | Asthma associated with obesity is considered the most severe phenotype and can be challenging to manage with standard medications. Marine-derived 1-<i>O</i>-alkyl-glycerols (AGs), as precursors for plasmalogen synthesis, have high biological activity, making them a promising substance for pharmacology. This study aimed to investigate the effect of AGs from squid <i>Berryteuthis magister</i> on lung function, fatty acid and plasmalogen levels, and cytokine and adipokine production in obese patients with asthma. The investigational trial included 19 patients with mild asthma associated with obesity who received 0.4 g of AGs daily for three months in addition to their standard treatment. The effects of AGs were evaluated at one and three months of treatment. The results of the study demonstrated that intake of AGs increased the FEV1 and FEV1/VC ratios, and significantly decreased the ACQ score in 17 of the 19 patients after three months of treatment. The intake of AGs increased concentration of plasmalogen and n–3 PUFA in plasma, and modified leptin/adiponectin production by adipose tissue. The supplementation of AGs decreased the plasma levels of inflammatory cytokines (TNF-α, IL-4, and IL-17a), and oxylipins (TXB2 and LTB4), suggesting an anti-inflammatory property of AGs. In conclusion, 1-<i>O</i>-alkyl-glycerols could be a promising dietary supplement for improving pulmonary function and reducing inflammation in obese asthma patients, and a natural source for plasmalogen synthesis. The study highlighted that the beneficial effects of AG consumption can be observed after one month of treatment, with gradual improvement after three months of supplementation. |
| first_indexed | 2024-03-11T02:13:43Z |
| format | Article |
| id | doaj.art-b1fa51fc591c44c9ad039afa9c126b19 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-11T02:13:43Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-b1fa51fc591c44c9ad039afa9c126b192023-11-18T11:22:41ZengMDPI AGMarine Drugs1660-33972023-06-0121635110.3390/md210603511-<i>O</i>-alkyl-glycerols from Squid <i>Berryteuthis magister</i> Reduce Inflammation and Modify Fatty Acid and Plasmalogen Metabolism in Asthma Associated with ObesityYulia Denisenko0Tatyana Novgorodtseva1Marina Antonyuk2Alla Yurenko3Tatyana Gvozdenko4Sergey Kasyanov5Ekaterina Ermolenko6Ruslan Sultanov7Vladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration, Institute of Medical Climatology and Rehabilitative Treatment, 690105 Vladivostok, RussiaVladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration, Institute of Medical Climatology and Rehabilitative Treatment, 690105 Vladivostok, RussiaVladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration, Institute of Medical Climatology and Rehabilitative Treatment, 690105 Vladivostok, RussiaVladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration, Institute of Medical Climatology and Rehabilitative Treatment, 690105 Vladivostok, RussiaVladivostok Branch of Far Eastern Scientific Center of Physiology and Pathology of Respiration, Institute of Medical Climatology and Rehabilitative Treatment, 690105 Vladivostok, RussiaA.V. Zhirmunsky National Scientific Center of Marine Biology (Far Eastern Branch), Russian Academy of Sciences, 17 Palchevskogo Str., 690041 Vladivostok, RussiaA.V. Zhirmunsky National Scientific Center of Marine Biology (Far Eastern Branch), Russian Academy of Sciences, 17 Palchevskogo Str., 690041 Vladivostok, RussiaA.V. Zhirmunsky National Scientific Center of Marine Biology (Far Eastern Branch), Russian Academy of Sciences, 17 Palchevskogo Str., 690041 Vladivostok, RussiaAsthma associated with obesity is considered the most severe phenotype and can be challenging to manage with standard medications. Marine-derived 1-<i>O</i>-alkyl-glycerols (AGs), as precursors for plasmalogen synthesis, have high biological activity, making them a promising substance for pharmacology. This study aimed to investigate the effect of AGs from squid <i>Berryteuthis magister</i> on lung function, fatty acid and plasmalogen levels, and cytokine and adipokine production in obese patients with asthma. The investigational trial included 19 patients with mild asthma associated with obesity who received 0.4 g of AGs daily for three months in addition to their standard treatment. The effects of AGs were evaluated at one and three months of treatment. The results of the study demonstrated that intake of AGs increased the FEV1 and FEV1/VC ratios, and significantly decreased the ACQ score in 17 of the 19 patients after three months of treatment. The intake of AGs increased concentration of plasmalogen and n–3 PUFA in plasma, and modified leptin/adiponectin production by adipose tissue. The supplementation of AGs decreased the plasma levels of inflammatory cytokines (TNF-α, IL-4, and IL-17a), and oxylipins (TXB2 and LTB4), suggesting an anti-inflammatory property of AGs. In conclusion, 1-<i>O</i>-alkyl-glycerols could be a promising dietary supplement for improving pulmonary function and reducing inflammation in obese asthma patients, and a natural source for plasmalogen synthesis. The study highlighted that the beneficial effects of AG consumption can be observed after one month of treatment, with gradual improvement after three months of supplementation.https://www.mdpi.com/1660-3397/21/6/351asthmaobesityobese asthma phenotype1-<i>O</i>-alkyl-glycerolsplasmalogens |
| spellingShingle | Yulia Denisenko Tatyana Novgorodtseva Marina Antonyuk Alla Yurenko Tatyana Gvozdenko Sergey Kasyanov Ekaterina Ermolenko Ruslan Sultanov 1-<i>O</i>-alkyl-glycerols from Squid <i>Berryteuthis magister</i> Reduce Inflammation and Modify Fatty Acid and Plasmalogen Metabolism in Asthma Associated with Obesity Marine Drugs asthma obesity obese asthma phenotype 1-<i>O</i>-alkyl-glycerols plasmalogens |
| title | 1-<i>O</i>-alkyl-glycerols from Squid <i>Berryteuthis magister</i> Reduce Inflammation and Modify Fatty Acid and Plasmalogen Metabolism in Asthma Associated with Obesity |
| title_full | 1-<i>O</i>-alkyl-glycerols from Squid <i>Berryteuthis magister</i> Reduce Inflammation and Modify Fatty Acid and Plasmalogen Metabolism in Asthma Associated with Obesity |
| title_fullStr | 1-<i>O</i>-alkyl-glycerols from Squid <i>Berryteuthis magister</i> Reduce Inflammation and Modify Fatty Acid and Plasmalogen Metabolism in Asthma Associated with Obesity |
| title_full_unstemmed | 1-<i>O</i>-alkyl-glycerols from Squid <i>Berryteuthis magister</i> Reduce Inflammation and Modify Fatty Acid and Plasmalogen Metabolism in Asthma Associated with Obesity |
| title_short | 1-<i>O</i>-alkyl-glycerols from Squid <i>Berryteuthis magister</i> Reduce Inflammation and Modify Fatty Acid and Plasmalogen Metabolism in Asthma Associated with Obesity |
| title_sort | 1 i o i alkyl glycerols from squid i berryteuthis magister i reduce inflammation and modify fatty acid and plasmalogen metabolism in asthma associated with obesity |
| topic | asthma obesity obese asthma phenotype 1-<i>O</i>-alkyl-glycerols plasmalogens |
| url | https://www.mdpi.com/1660-3397/21/6/351 |
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