Exogenous Hydrogen Sulfide Plays an Important Role by Regulating Autophagy in Diabetic-Related Diseases
Autophagy is a vital cell mechanism which plays an important role in many physiological processes including clearing long-lived, accumulated and misfolded proteins, removing damaged organelles and regulating growth and aging. Autophagy also participates in a variety of biological functions, such as...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/13/6715 |
| _version_ | 1797529110281453568 |
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| author | Shuangyu Lv Huiyang Liu Honggang Wang |
| author_facet | Shuangyu Lv Huiyang Liu Honggang Wang |
| author_sort | Shuangyu Lv |
| collection | DOAJ |
| description | Autophagy is a vital cell mechanism which plays an important role in many physiological processes including clearing long-lived, accumulated and misfolded proteins, removing damaged organelles and regulating growth and aging. Autophagy also participates in a variety of biological functions, such as development, cell differentiation, resistance to pathogens and nutritional hunger. Recently, autophagy has been reported to be involved in diabetes, but the mechanism is not fully understood. Hydrogen sulfide (H<sub>2</sub>S) is a colorless, water-soluble, flammable gas with the typical odor of rotten eggs, which has been known as a highly toxic gas for many years. However, it has been reported recently that H<sub>2</sub>S, together with nitric oxide and carbon monoxide, is an important gas signal transduction molecule. H<sub>2</sub>S has been reported to play a protective role in many diabetes-related diseases, but the mechanism is not fully clear. Recent studies indicate that H<sub>2</sub>S plays an important role by regulating autophagy in many diseases including cancer, tissue fibrosis diseases and glycometabolic diseases; however, the related mechanism has not been fully studied. In this review, we summarize recent research on the role of H<sub>2</sub>S in regulating autophagy in diabetic-related diseases to provide references for future related research. |
| first_indexed | 2024-03-10T10:08:46Z |
| format | Article |
| id | doaj.art-b1fa773c242846b99b82093aa51c36b7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:08:46Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b1fa773c242846b99b82093aa51c36b72023-11-22T01:20:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012213671510.3390/ijms22136715Exogenous Hydrogen Sulfide Plays an Important Role by Regulating Autophagy in Diabetic-Related DiseasesShuangyu Lv0Huiyang Liu1Honggang Wang2Henan International Joint Laboratory of Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475000, ChinaHenan International Joint Laboratory of Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475000, ChinaHenan International Joint Laboratory of Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475000, ChinaAutophagy is a vital cell mechanism which plays an important role in many physiological processes including clearing long-lived, accumulated and misfolded proteins, removing damaged organelles and regulating growth and aging. Autophagy also participates in a variety of biological functions, such as development, cell differentiation, resistance to pathogens and nutritional hunger. Recently, autophagy has been reported to be involved in diabetes, but the mechanism is not fully understood. Hydrogen sulfide (H<sub>2</sub>S) is a colorless, water-soluble, flammable gas with the typical odor of rotten eggs, which has been known as a highly toxic gas for many years. However, it has been reported recently that H<sub>2</sub>S, together with nitric oxide and carbon monoxide, is an important gas signal transduction molecule. H<sub>2</sub>S has been reported to play a protective role in many diabetes-related diseases, but the mechanism is not fully clear. Recent studies indicate that H<sub>2</sub>S plays an important role by regulating autophagy in many diseases including cancer, tissue fibrosis diseases and glycometabolic diseases; however, the related mechanism has not been fully studied. In this review, we summarize recent research on the role of H<sub>2</sub>S in regulating autophagy in diabetic-related diseases to provide references for future related research.https://www.mdpi.com/1422-0067/22/13/6715hydrogen sulfideautophagydiabetessignaling pathwayoxidative stress |
| spellingShingle | Shuangyu Lv Huiyang Liu Honggang Wang Exogenous Hydrogen Sulfide Plays an Important Role by Regulating Autophagy in Diabetic-Related Diseases International Journal of Molecular Sciences hydrogen sulfide autophagy diabetes signaling pathway oxidative stress |
| title | Exogenous Hydrogen Sulfide Plays an Important Role by Regulating Autophagy in Diabetic-Related Diseases |
| title_full | Exogenous Hydrogen Sulfide Plays an Important Role by Regulating Autophagy in Diabetic-Related Diseases |
| title_fullStr | Exogenous Hydrogen Sulfide Plays an Important Role by Regulating Autophagy in Diabetic-Related Diseases |
| title_full_unstemmed | Exogenous Hydrogen Sulfide Plays an Important Role by Regulating Autophagy in Diabetic-Related Diseases |
| title_short | Exogenous Hydrogen Sulfide Plays an Important Role by Regulating Autophagy in Diabetic-Related Diseases |
| title_sort | exogenous hydrogen sulfide plays an important role by regulating autophagy in diabetic related diseases |
| topic | hydrogen sulfide autophagy diabetes signaling pathway oxidative stress |
| url | https://www.mdpi.com/1422-0067/22/13/6715 |
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