Extensive Metastatic Sarcomatoid Renal Cell Carcinoma Evaluated by 18F-FDG PET/CT: a Case Report and Review of Literature
Sarcomatoid renal cell carcinoma (sRCC) is a highly aggressive form of dedifferentiated renal cell carcinoma. We report a 62-yearold man who presented with respiratory symptoms and a lung mass on chest computed tomography (CT). The patient underwent positron emission tomography/computed tomography (...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Codon Publications
2018-01-01
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| Series: | Journal of Kidney Cancer and VHL |
| Subjects: | |
| Online Access: | https://jkcvhl.com/index.php/jkcvhl/article/view/99 |
| _version_ | 1819181056554696704 |
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| author | Dominique Fuser Matthew L. Hedberg Louis P. Dehner Farrokh Dehdashti Barry A. Siegel |
| author_facet | Dominique Fuser Matthew L. Hedberg Louis P. Dehner Farrokh Dehdashti Barry A. Siegel |
| author_sort | Dominique Fuser |
| collection | DOAJ |
| description | Sarcomatoid renal cell carcinoma (sRCC) is a highly aggressive form of dedifferentiated renal cell carcinoma. We report a 62-yearold man who presented with respiratory symptoms and a lung mass on chest computed tomography (CT). The patient underwent positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (18F-FDG) and was found to have extensive metastatic disease. Based on the history and imaging findings, there were possible primary malignancies, including bronchogenic carcinoma, melanoma, or an aggressive lymphoma. An excisional biopsy surprisingly revealed a high-grade sarcomatoid carcinoma with no evidence of differentiation, and immunohistochemical (IHC) studies showed that the tumor cells were positive for markers of genitourinary origin (PAX-8 and vimentin). The histologic and IHC results, along with multiple FDG-avid exophytic lesions in both kidneys, were considered diagnostic of sRCC. Here we have highlighted the potential role of 18F-FDG-PET-CT in patients with sRCC, discussed the diagnostic challenges, and presented a brief review. |
| first_indexed | 2024-12-22T22:24:10Z |
| format | Article |
| id | doaj.art-b1fc2afc9924449e932c62d75d2166bc |
| institution | Directory Open Access Journal |
| issn | 2203-5826 |
| language | English |
| last_indexed | 2024-12-22T22:24:10Z |
| publishDate | 2018-01-01 |
| publisher | Codon Publications |
| record_format | Article |
| series | Journal of Kidney Cancer and VHL |
| spelling | doaj.art-b1fc2afc9924449e932c62d75d2166bc2022-12-21T18:10:35ZengCodon PublicationsJournal of Kidney Cancer and VHL2203-58262018-01-015110.15586/jkcvhl.2018.99Extensive Metastatic Sarcomatoid Renal Cell Carcinoma Evaluated by 18F-FDG PET/CT: a Case Report and Review of LiteratureDominique FuserMatthew L. HedbergLouis P. DehnerFarrokh DehdashtiBarry A. SiegelSarcomatoid renal cell carcinoma (sRCC) is a highly aggressive form of dedifferentiated renal cell carcinoma. We report a 62-yearold man who presented with respiratory symptoms and a lung mass on chest computed tomography (CT). The patient underwent positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (18F-FDG) and was found to have extensive metastatic disease. Based on the history and imaging findings, there were possible primary malignancies, including bronchogenic carcinoma, melanoma, or an aggressive lymphoma. An excisional biopsy surprisingly revealed a high-grade sarcomatoid carcinoma with no evidence of differentiation, and immunohistochemical (IHC) studies showed that the tumor cells were positive for markers of genitourinary origin (PAX-8 and vimentin). The histologic and IHC results, along with multiple FDG-avid exophytic lesions in both kidneys, were considered diagnostic of sRCC. Here we have highlighted the potential role of 18F-FDG-PET-CT in patients with sRCC, discussed the diagnostic challenges, and presented a brief review.https://jkcvhl.com/index.php/jkcvhl/article/view/99FDG PET/CTmetastasisPET/CTrenal cell carcinomasarcomatoid |
| spellingShingle | Dominique Fuser Matthew L. Hedberg Louis P. Dehner Farrokh Dehdashti Barry A. Siegel Extensive Metastatic Sarcomatoid Renal Cell Carcinoma Evaluated by 18F-FDG PET/CT: a Case Report and Review of Literature Journal of Kidney Cancer and VHL FDG PET/CT metastasis PET/CT renal cell carcinoma sarcomatoid |
| title | Extensive Metastatic Sarcomatoid Renal Cell Carcinoma Evaluated by 18F-FDG PET/CT: a Case Report and Review of Literature |
| title_full | Extensive Metastatic Sarcomatoid Renal Cell Carcinoma Evaluated by 18F-FDG PET/CT: a Case Report and Review of Literature |
| title_fullStr | Extensive Metastatic Sarcomatoid Renal Cell Carcinoma Evaluated by 18F-FDG PET/CT: a Case Report and Review of Literature |
| title_full_unstemmed | Extensive Metastatic Sarcomatoid Renal Cell Carcinoma Evaluated by 18F-FDG PET/CT: a Case Report and Review of Literature |
| title_short | Extensive Metastatic Sarcomatoid Renal Cell Carcinoma Evaluated by 18F-FDG PET/CT: a Case Report and Review of Literature |
| title_sort | extensive metastatic sarcomatoid renal cell carcinoma evaluated by 18f fdg pet ct a case report and review of literature |
| topic | FDG PET/CT metastasis PET/CT renal cell carcinoma sarcomatoid |
| url | https://jkcvhl.com/index.php/jkcvhl/article/view/99 |
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