Design considerations for clinical trials in aphasia
The use of the randomised controlled trial (RCT) design to evaluate the effectiveness of new interventions in aphasia has increased in recent years in response to calls for high quality evidence of the effectiveness of interventions for this population. This view-point article highlights some of the...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Annals of Indian Academy of Neurology |
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| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2020;volume=23;issue=8;spage=52;epage=56;aulast=Palmer |
| _version_ | 1818360770347401216 |
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| author | Rebecca Palmer |
| author_facet | Rebecca Palmer |
| author_sort | Rebecca Palmer |
| collection | DOAJ |
| description | The use of the randomised controlled trial (RCT) design to evaluate the effectiveness of new interventions in aphasia has increased in recent years in response to calls for high quality evidence of the effectiveness of interventions for this population. This view-point article highlights some of the important considerations when designing a trial for an aphasia intervention, illustrated with decisions made when designing the Big CACTUS RCT for self-managed computer-based word finding therapy in aphasia. Considerations outlined include whether an RCT is needed, readiness for conducting an RCT, choice of comparators, randomisation options, blinding/masking, selection of outcome measures, pragmatic versus explanatory approaches, and fidelity measurement. |
| first_indexed | 2024-12-13T21:06:04Z |
| format | Article |
| id | doaj.art-b1fc35ccd7284d868b8ff2d23cfdfdd7 |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-12-13T21:06:04Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-b1fc35ccd7284d868b8ff2d23cfdfdd72022-12-21T23:31:29ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492020-01-01238525610.4103/aian.AIAN_453_20Design considerations for clinical trials in aphasiaRebecca PalmerThe use of the randomised controlled trial (RCT) design to evaluate the effectiveness of new interventions in aphasia has increased in recent years in response to calls for high quality evidence of the effectiveness of interventions for this population. This view-point article highlights some of the important considerations when designing a trial for an aphasia intervention, illustrated with decisions made when designing the Big CACTUS RCT for self-managed computer-based word finding therapy in aphasia. Considerations outlined include whether an RCT is needed, readiness for conducting an RCT, choice of comparators, randomisation options, blinding/masking, selection of outcome measures, pragmatic versus explanatory approaches, and fidelity measurement.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2020;volume=23;issue=8;spage=52;epage=56;aulast=Palmeraphasiarandomised controlled trialstrial design |
| spellingShingle | Rebecca Palmer Design considerations for clinical trials in aphasia Annals of Indian Academy of Neurology aphasia randomised controlled trials trial design |
| title | Design considerations for clinical trials in aphasia |
| title_full | Design considerations for clinical trials in aphasia |
| title_fullStr | Design considerations for clinical trials in aphasia |
| title_full_unstemmed | Design considerations for clinical trials in aphasia |
| title_short | Design considerations for clinical trials in aphasia |
| title_sort | design considerations for clinical trials in aphasia |
| topic | aphasia randomised controlled trials trial design |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2020;volume=23;issue=8;spage=52;epage=56;aulast=Palmer |
| work_keys_str_mv | AT rebeccapalmer designconsiderationsforclinicaltrialsinaphasia |