Alterations in macrophage polarization in the craniofacial and extracranial skeleton after zoledronate application and surgical interventions – an in vivo experiment

Alterations in macrophage polarization in the craniofacial and extracranial skeleton after zoledronate application and surgical interventions – an in vivo experiment

PurposeMedication-related osteonecrosis occurs exclusively in the jaw bones. However, the exact pathogenesis of medication-related osteonecrosis of the jaw (MRONJ) and the unique predisposition of the jaw bones have not been elucidated, making its treatment a challenge. Recent evidence indicates tha...

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Bibliographic Details
Main Authors: Ann-Kristin Struckmeier, Falk Wehrhan, Raimund Preidl, Melanie Mike, Tina Mönch, Lea Eilers, Jutta Ries, Leah Trumet, Rainer Lutz, Carol Geppert, Marco Kesting, Manuel Weber
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
osteonecrosis
bisphosphonate
macrophage
tooth extraction
MRONJ
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1204188/full

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