Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions
Abstract The 2019 coronavirus disease (COVID‐19) pandemic has become a global crisis. In the immunopathogenesis of COVID‐19, SARS‐CoV‐2 infection induces an excessive inflammatory response in patients, causing an inflammatory cytokine storm in severe cases. Cytokine storm leads to acute respiratory...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-09-01
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| Series: | MedComm |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mco2.154 |
| _version_ | 1817986911719915520 |
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| author | Yujie Jiang Tingmei Zhao Xueyan Zhou Yu Xiang Pedro Gutierrez‐Castrellon Xuelei Ma |
| author_facet | Yujie Jiang Tingmei Zhao Xueyan Zhou Yu Xiang Pedro Gutierrez‐Castrellon Xuelei Ma |
| author_sort | Yujie Jiang |
| collection | DOAJ |
| description | Abstract The 2019 coronavirus disease (COVID‐19) pandemic has become a global crisis. In the immunopathogenesis of COVID‐19, SARS‐CoV‐2 infection induces an excessive inflammatory response in patients, causing an inflammatory cytokine storm in severe cases. Cytokine storm leads to acute respiratory distress syndrome, pulmonary and other multiorgan failure, which is an important cause of COVID‐19 progression and even death. Among them, activation of inflammatory pathways is a major factor in generating cytokine storms and causing dysregulated immune responses, which is closely related to the severity of viral infection. Therefore, elucidation of the inflammatory signaling pathway of SARS‐CoV‐2 is important in providing otential therapeutic targets and treatment strategies against COVID‐19. Here, we discuss the major inflammatory pathways in the pathogenesis of COVID‐19, including induction, function, and downstream signaling, as well as existing and potential interventions targeting these cytokines or related signaling pathways. We believe that a comprehensive understanding of the regulatory pathways of COVID‐19 immune dysregulation and inflammation will help develop better clinical therapy strategies to effectively control inflammatory diseases, such as COVID‐19. |
| first_indexed | 2024-04-14T00:15:23Z |
| format | Article |
| id | doaj.art-b1feac837ad441b3839c8257c2178f9e |
| institution | Directory Open Access Journal |
| issn | 2688-2663 |
| language | English |
| last_indexed | 2024-04-14T00:15:23Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj.art-b1feac837ad441b3839c8257c2178f9e2022-12-22T02:23:08ZengWileyMedComm2688-26632022-09-0133n/an/a10.1002/mco2.154Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventionsYujie Jiang0Tingmei Zhao1Xueyan Zhou2Yu Xiang3Pedro Gutierrez‐Castrellon4Xuelei Ma5Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital Sichuan University Chengdu PR ChinaLaboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital Sichuan University Chengdu PR ChinaLaboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital Sichuan University Chengdu PR ChinaDepartment of Biotherapy State Key Laboratory of Biotherapy Cancer Center West China Hospital Sichuan University Chengdu PR ChinaCenter for Translational Research on Health Science Hospital General Dr. Manuel Gea Gonzalez Ministry of Health Mexico City MexicoDepartment of Biotherapy State Key Laboratory of Biotherapy Cancer Center West China Hospital Sichuan University Chengdu PR ChinaAbstract The 2019 coronavirus disease (COVID‐19) pandemic has become a global crisis. In the immunopathogenesis of COVID‐19, SARS‐CoV‐2 infection induces an excessive inflammatory response in patients, causing an inflammatory cytokine storm in severe cases. Cytokine storm leads to acute respiratory distress syndrome, pulmonary and other multiorgan failure, which is an important cause of COVID‐19 progression and even death. Among them, activation of inflammatory pathways is a major factor in generating cytokine storms and causing dysregulated immune responses, which is closely related to the severity of viral infection. Therefore, elucidation of the inflammatory signaling pathway of SARS‐CoV‐2 is important in providing otential therapeutic targets and treatment strategies against COVID‐19. Here, we discuss the major inflammatory pathways in the pathogenesis of COVID‐19, including induction, function, and downstream signaling, as well as existing and potential interventions targeting these cytokines or related signaling pathways. We believe that a comprehensive understanding of the regulatory pathways of COVID‐19 immune dysregulation and inflammation will help develop better clinical therapy strategies to effectively control inflammatory diseases, such as COVID‐19.https://doi.org/10.1002/mco2.154COVID‐19cytokine stormimmunopathologyimmunotherapyinflammatory pathways |
| spellingShingle | Yujie Jiang Tingmei Zhao Xueyan Zhou Yu Xiang Pedro Gutierrez‐Castrellon Xuelei Ma Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions MedComm COVID‐19 cytokine storm immunopathology immunotherapy inflammatory pathways |
| title | Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions |
| title_full | Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions |
| title_fullStr | Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions |
| title_full_unstemmed | Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions |
| title_short | Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions |
| title_sort | inflammatory pathways in covid 19 mechanism and therapeutic interventions |
| topic | COVID‐19 cytokine storm immunopathology immunotherapy inflammatory pathways |
| url | https://doi.org/10.1002/mco2.154 |
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