Genetic Background Influences the Propagation of Tau Pathology in Transgenic Rodent Models of Tauopathy

Genetic Background Influences the Propagation of Tau Pathology in Transgenic Rodent Models of Tauopathy

Alzheimer’s disease (AD), the most common tauopathy, is an age-dependent, progressive neurodegenerative disease. Epidemiological studies implicate the role of genetic background in the onset and progression of AD. Despite mutations in familial AD, several risk factors have been implicated in sporadi...

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Bibliographic Details
Main Authors: Tomas Smolek, Veronika Cubinkova, Veronika Brezovakova, Bernadeta Valachova, Peter Szalay, Norbert Zilka, Santosh Jadhav
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Aging Neuroscience
Subjects:
tauopathy
neurofibrillary tangles
microglia
genetic background
ramified
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00343/full

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