Calcium oscillations in HEK293 cells lacking SOCE suggest the existence of a balanced regulation of IP3 production and degradation

Calcium oscillations in HEK293 cells lacking SOCE suggest the existence of a balanced regulation of IP3 production and degradation

The concentration of free cytosolic Ca2+ is a critical second messenger in almost every cell type, with the signal often being carried by the period of oscillations, or spikes, in the cytosolic Ca2+ concentration. We have previously studied how Ca2+ influx across the plasma membrane affects the peri...

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Bibliographic Details
Main Authors: Clara Octors, Ryan E. Yoast, Scott M. Emrich, Mohamed Trebak, James Sneyd
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Systems Biology
Subjects:
calcium oscillation
calcium influx
HEK293 cells
SOCE
PLC regulation
IP3
Online Access:https://www.frontiersin.org/articles/10.3389/fsysb.2024.1343006/full

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