MALAT1-miR-30c-5p-CTGF/ATG5 axis regulates silica-induced experimental silicosis by mediating EMT in alveolar epithelial cells

MALAT1-miR-30c-5p-CTGF/ATG5 axis regulates silica-induced experimental silicosis by mediating EMT in alveolar epithelial cells

Epithelial-mesenchymal transdifferentiation of alveolar type Ⅱ epithelial cells is a vital source of pulmonary myofibroblasts, and myofibroblasts formation is recognized as an important phase in the pathological process of silicosis. miR-30c-5p has been determined to be relevant in the activation of...

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Bibliographic Details
Main Authors: Jiarui Xia, Yangyang Tian, Zheng Shao, Chao Li, Mingcui Ding, Yuanmeng Qi, Xiao Xu, Kai Dai, Chenchen Wu, Wu Yao, Changfu Hao
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Silicosis
EMT
miR-30c-5p
MALAT1
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651322012325

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