Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress
Intrauterine growth restriction is associated with increased risk for chronic diseases in adults. Here the authors identify fetuin-A as a HIF target gene and describe its protective role in the kidney, counteracting disease mechanisms such as calcification, macrophage polarization, and fibrosis.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20832-7 |
| _version_ | 1831570580452671488 |
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| author | Stefan Rudloff Mathilde Janot Stephane Rodriguez Kevin Dessalle Willi Jahnen-Dechent Uyen Huynh-Do |
| author_facet | Stefan Rudloff Mathilde Janot Stephane Rodriguez Kevin Dessalle Willi Jahnen-Dechent Uyen Huynh-Do |
| author_sort | Stefan Rudloff |
| collection | DOAJ |
| description | Intrauterine growth restriction is associated with increased risk for chronic diseases in adults. Here the authors identify fetuin-A as a HIF target gene and describe its protective role in the kidney, counteracting disease mechanisms such as calcification, macrophage polarization, and fibrosis. |
| first_indexed | 2024-12-17T12:53:40Z |
| format | Article |
| id | doaj.art-b20321b21d3a4a83a7ef31a0fb9d941a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T12:53:40Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b20321b21d3a4a83a7ef31a0fb9d941a2022-12-21T21:47:32ZengNature PortfolioNature Communications2041-17232021-01-0112111610.1038/s41467-020-20832-7Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stressStefan Rudloff0Mathilde Janot1Stephane Rodriguez2Kevin Dessalle3Willi Jahnen-Dechent4Uyen Huynh-Do5Department of Nephrology and Hypertension, Bern University HospitalDepartment of Nephrology and Hypertension, Bern University HospitalDepartment of Nephrology and Hypertension, Bern University HospitalDepartment of Nephrology and Hypertension, Bern University HospitalHelmholtz-Institute for Biomedical Engineering, Biointerface Laboratory, RWTH Aachen University Medical FacultyDepartment of Nephrology and Hypertension, Bern University HospitalIntrauterine growth restriction is associated with increased risk for chronic diseases in adults. Here the authors identify fetuin-A as a HIF target gene and describe its protective role in the kidney, counteracting disease mechanisms such as calcification, macrophage polarization, and fibrosis.https://doi.org/10.1038/s41467-020-20832-7 |
| spellingShingle | Stefan Rudloff Mathilde Janot Stephane Rodriguez Kevin Dessalle Willi Jahnen-Dechent Uyen Huynh-Do Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress Nature Communications |
| title | Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress |
| title_full | Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress |
| title_fullStr | Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress |
| title_full_unstemmed | Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress |
| title_short | Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress |
| title_sort | fetuin a is a hif target that safeguards tissue integrity during hypoxic stress |
| url | https://doi.org/10.1038/s41467-020-20832-7 |
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